Geert Jan Biessels

Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial disease--Magnetic Resonance (SMART-MR) study.

Ageing and diabetes: implications for brain function.

Neuronal Ca2+ disregulation in diabetes mellitus.

Effects of a phorbol ester and cyclosporin A on hippocampal synaptic plasticity in streptozotocin-induced-diabetic rats: reduced sensitivity to phorbol esters.

Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats.

Nerve conduction velocity and evoked potential latencies in streptozotocin-diabetic rats: effects of treatment with an angiotensin converting enzyme inhibitor.

Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface.

Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels.

Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

The effects of type 1 diabetes on cognitive performance: a meta-analysis.

The effect of short duration streptozotocin-induced diabetes mellitus on the late phase and threshold of long-term potentiation induction in the rat.

The impact of diabetes on cognition: what can be learned from rodent models?

Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic.

Risk of dementia in diabetes mellitus: a systematic review.

Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats.

Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat.

Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes.

Cognitive performance, psychological well-being, and brain magnetic resonance imaging in older patients with type 1 diabetes.

Brain imaging in patients with diabetes: a systematic review.

A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus.

Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study.

Cognition and diabetes: a lifespan perspective.

Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease.

Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review.

Structural brain imaging in diabetes: a methodological perspective.

Cognitive dysfunction and diabetes: implications for primary care.

Construction of periventricular white matter hyperintensity maps by spatial normalization of the lateral ventricles.

Cognitive functioning in elderly persons with type 2 diabetes and metabolic syndrome: the Hoorn study.

Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition.

Cognition in the early stage of type 2 diabetes.

Hyperglycemia and clinical outcome in aneurysmal subarachnoid hemorrhage: a meta-analysis.

White matter lesions and brain atrophy: more than shared risk factors? A systematic review.

Diabetes: hypoglycemia and dementia in type 2 diabetes: chick or egg?

Blood pressure levels in pre-diabetic stages are associated with worse cognitive functioning in patients with type 2 diabetes.

MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance.

Ten-year time course of risk factors for increased carotid intima-media thickness: the Hoorn Study.

Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management.

Caffeine, diabetes, cognition, and dementia.

Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes.

Glycemia and levels of cerebrospinal fluid amyloid and tau in patients attending a memory clinic.

Visualization of cerebral microbleeds with dual-echo T2*-weighted magnetic resonance imaging at 7.0 T.

Hyperglycemia in aneurysmal subarachnoid hemorrhage: a potentially modifiable risk factor for poor outcome.

Perfusion CT in suspected ischaemic stroke: red flags that should have been blue.

Cognitive dysfunction in patients with type 2 diabetes.

No evidence of microbleeds in ALS patients at 7 Tesla MRI.

Cerebral cortical thickness in patients with type 2 diabetes.

A comparison of MR based segmentation methods for measuring brain atrophy progression.

Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes.

Should we target insulin resistance to prevent dementia due to Alzheimer disease?

Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors.

Vascular risk scores for dementia: age matters.

Cognition in older patients with type 1 diabetes mellitus: a longitudinal study.

Intensive insulin therapy increases the risk of hypoglycemia in neurocritical care patients.

Diabetic Polyneuropathies: Update on Research Definition, Diagnostic Criteria and Estimation of Severity.

Intracranial vessel wall imaging at 7.0-T MRI.

Intensive glucose lowering and cognition in type 2 diabetes.

The metabolic syndrome, atherosclerosis and cognitive functioning in a non-demented population: the Hoorn Study.

Efficient detection of cerebral microbleeds on 7.0 T MR images using the radial symmetry transform.

Heart failure and cognitive function in the general population: the Hoorn Study.

Intensive multifactorial treatment and cognitive functioning in screen-detected type 2 diabetes--the ADDITION-Netherlands study: a cluster-randomized trial.

Effect of chronic intracerebroventricular insulin administration in rats on the peripheral glucose metabolism and synaptic plasticity of CA1 hippocampal neurons.

Cerebral microinfarcts: a systematic review of neuropathological studies.

Diabetes, hyperglycaemia, and acute ischaemic stroke.

The Telephone Interview for Cognitive Status (Modified): relation with a comprehensive neuropsychological assessment.

Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes.

High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease.

Mild depressive symptoms do not influence cognitive functioning in patients with type 2 diabetes.

Unraveling the puzzle of dementia risk in diabetes.

Development of vascular risk factors over 15 years in relation to cognition: the Hoorn Study.

Quantification of cerebral volumes on MRI 6 months after aneurysmal subarachnoid hemorrhage.

Improved sensitivity to cerebral white matter abnormalities in Alzheimer's disease with spherical deconvolution based tractography.

Microstructural white matter abnormalities and cognitive functioning in type 2 diabetes: a diffusion tensor imaging study.

In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI.

Disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes.

Dysglycemia, brain volume and vascular lesions on MRI in a memory clinic population.

Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanisms.

Admission hyperglycaemia and cerebral perfusion deficits in acute ischaemic stroke.

Cerebral microinfarcts: Enumerating the innumerable.

Disruption of cerebral networks and cognitive impairment in Alzheimer disease.

Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls.

The "Test Your Memory" test performs better than the MMSE in a population without known cognitive dysfunction.

Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review.

The effect of lacunar infarcts on white matter tract integrity.

Semi-Automated Detection of Cerebral Microbleeds on 3.0 T MR Images.

Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study.

Sweet memories: 20 years of progress in research on cognitive functioning in diabetes.

Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease.

Midlife risk score for the prediction of dementia four decades later.

Reliability of visual assessment of non-contrast CT, CT angiography source images and CT perfusion in patients with suspected ischemic stroke.

Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease.

How to assess the reliability of cerebral microbleed rating?

Hippocampal T2 hyperintensities on 7 Tesla MRI.

Brain MRI correlates of cognitive dysfunction in type 2 diabetes: the needle recovered from the haystack?

Automatic extraction of the midsagittal surface from brain MR Images using the Kullback-Leibler measure.

Brain MRI in children with type 1 diabetes: snapshot or road map of developmental changes?

Visualization of perivascular spaces and perforating arteries with 7 T magnetic resonance imaging.

Symptom Checklist 90-Revised in neurological outpatients.

Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains.

Cerebral microbleeds are not associated with long-term cognitive outcome in patients with transient ischemic attack or minor stroke.

Prediction of outcome in patients with suspected acute ischaemic stroke with CT perfusion and CT angiography: the Dutch acute stroke trial (DUST) study protocol.

Outcome markers for clinical trials in cerebral amyloid angiopathy.

Risk score for prediction of 10 year dementia risk in individuals with type 2 diabetes: a cohort study.

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions.

Severe diabetic retinal disease and dementia risk in type 2 diabetes.

Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging.

Brain imaging in type 2 diabetes.

High resolution imaging of cerebral small vessel disease with 7 T MRI.

Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage.

Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes.

Vascular retinopathy in relation to cognitive functioning in an older population--the Hoorn Study.

Developing biomarkers for cerebral amyloid angiopathy trials: do potential disease phenotypes hold promise? - authors' reply.

Absolute and relative temporal order memory for performed activities following stroke.

Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?

Global brain atrophy but not hippocampal atrophy is related to type 2 diabetes.

Capitalising on modifiable risk factors for Alzheimer's disease.

The anatomy of visuospatial construction revealed by lesion-symptom mapping.

Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review.

Ischaemic cavities in the cerebellum: an ex vivo 7-tesla MRI study with pathological correlation.

The heart-brain connection: a multidisciplinary approach targeting a missing link in the pathophysiology of vascular cognitive impairment.

A Critical Appraisal of the Hippocampal Subfield Segmentation Package in FreeSurfer.

FLAIR images at 7 Tesla MRI highlight the ependyma and the outer layers of the cerebral cortex.

Bayesian model selection for pathological data.

Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy.

Cognitive disorders in diabetic patients.

Distinct anatomical correlates of discriminability and criterion setting in verbal recognition memory revealed by lesion-symptom mapping.

Cortical microinfarcts detected in vivo on 3 Tesla MRI: clinical and radiological correlates.

Quantification of structural cerebral abnormalities on MRI 18 months after aneurysmal subarachnoid hemorrhage in patients who received endovascular treatment.

Residual high-grade stenosis after recanalization of extracranial carotid occlusion in acute ischemic stroke.

The Dutch Parelsnoer Institute--Neurodegenerative diseases; methods, design and baseline results.

Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI.

The spectrum of MR detectable cortical microinfarcts: a classification study with 7-tesla postmortem MRI and histopathology.

Hippocampal disconnection in early Alzheimer's disease: a 7 tesla MRI study.

Relation between stroke severity, patient characteristics and CT-perfusion derived blood-brain barrier permeability measurements in acute ischemic stroke.

Cognitive function in patients with diabetes mellitus: guidance for daily care.

The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis.

7Tesla vessel wall imaging of the basilar artery in perimesencephalic hemorrhage.

Bayesian Model Selection for Pathological Neuroimaging Data Applied to White Matter Lesion Segmentation.

Shared and distinct anatomical correlates of semantic and phonemic fluency revealed by lesion-symptom mapping in patients with ischemic stroke.

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients.

Acute nephropathy after contrast agent administration for computed tomography perfusion and computed tomography angiography in patients with acute ischemic stroke.

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer's dementia.

Brain changes in T1DM--a microvascular complication?

Cognitive Impairment in Diabetes: Rationale and Design Protocol of the Cog-ID Study.

Cortical microinfarcts on 7 T MRI in patients with spontaneous intracerebral hemorrhage.

Undiagnosed cognitive impairment, health status and depressive symptoms in patients with type 2 diabetes.

Completeness of the circle of Willis and risk of ischemic stroke in patients without cerebrovascular disease.

Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease.

Hippocampal insulin resistance and cognitive dysfunction.

The Prognostic Value of CT Angiography and CT Perfusion in Acute Ischemic Stroke.