Ton J. Rabelink

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes.

Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.

Endothelial progenitor cells: more than an inflammatory response?

An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men.

Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis.

The role of nitric oxide in renal transplantation.

Endothelial nitric oxide synthase: host defense enzyme of the endothelium?

Endothelial progenitor cell dysfunction in type 1 diabetes: another consequence of oxidative stress?

Endothelial progenitor cells: biology and therapeutic potential in hypertension.

New horizons in prevention and treatment of ischaemic injury to kidney transplants.

Opportunities and challenges for mesenchymal stem cell-mediated heart repair.

Preservation of beta-cell function by targeting beta-cell mass.

Recombinant human GH replacement increases CD34+ cells and improves endothelial function in adults with GH deficiency.

Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor.

Prevention of sudden cardiac death: rationale and design of the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) Trial--a prospective pilot study.

Complement activation by tubular cells is mediated by properdin binding.

Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis.

Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia.

The current status of interventions aiming at reducing sudden cardiac death in dialysis patients.

Salt is getting under our skin.

Usefulness of carotid intima-media thickness in patients with diabetes mellitus as a predictor of coronary artery disease.

Endothelial dysfunction in diabetic patients with abnormal myocardial perfusion in the absence of epicardial obstructive coronary artery disease.

Increased carotid intima-media thickness as a predictor of the presence and extent of abnormal myocardial perfusion in type 2 diabetes.

Urinary properdin excretion is associated with intrarenal complement activation and poor renal function.

Endothelial activation and circulating markers of endothelial activation in kidney disease.

Improved viscosity modeling in patients with type 2 diabetes mellitus by accounting for enhanced red blood cell aggregation tendency.

[Endothelial progenitor cells: what are we talking about?].

How to reduce the incidence of contrast induced acute kidney injury after cardiac invasive procedures, a review and practical recommendations.

Low Mannose-Binding Lectin (MBL) genotype is associated with future cardiovascular events in type 2 diabetic South Asians. A prospective cohort study.

Relationship between vascular stiffness and stress myocardial perfusion imaging in asymptomatic patients with diabetes.

Immunosuppression and the abdominal aortic aneurysm: Doctor Jekyll or Mister Hyde?

Dexamethasone increases ROS production and T cell suppressive capacity by anti-inflammatory macrophages.

How to reduce sudden cardiac death in patients with renal failure.

Left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis: prevalence and determinants.

Republished: How to reduce sudden cardiac death in patients with renal failure.

Late calcineurin inhibitor withdrawal prevents progressive left ventricular diastolic dysfunction in renal transplant recipients.

Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients.

Relationship between left ventricular diastolic function and arterial stiffness in asymptomatic patients with diabetes mellitus.

The role of mesenchymal stromal cells in chronic transplant rejection after solid organ transplantation.

A possible role of cystatin C in adipose tissue homeostasis may impact kidney function estimation in metabolic syndrome.

Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study.

The endothelial glycocalyx as a potential modifier of the hemolytic uremic syndrome.

Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease.

Bone marrow-derived mesenchymal stromal cells from patients with end-stage renal disease are suitable for autologous therapy.

Topologically heterogeneous beta cell adaptation in response to high-fat diet in mice.

Glomerular endothelial surface layer acts as a barrier against albumin filtration.

Arteriovenous access failure: more than just intimal hyperplasia?

Candidate gene analysis of arteriovenous fistula failure in hemodialysis patients.

Conversion of mature human β-cells into glucagon-producing α-cells.

Metabolic imaging of human kidney triglyceride content: reproducibility of proton magnetic resonance spectroscopy.

Vascular remodeling and intimal hyperplasia in a novel murine model of arteriovenous fistula failure.

The Role of microRNA-126 in Vascular Homeostasis.

Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials.

Renal ischemia-reperfusion induces release of angiopoietin-2 from human grafts of living and deceased donors.

Mesenchymal stromal cell therapy for cardio renal disorders.

CT coronary angiography is feasible for the assessment of coronary artery disease in chronic dialysis patients, despite high average calcium scores.

Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study.

Maximising impact of small cohort studies.

Echocardiographical determinants of an abnormal spatial QRS-T angle in chronic dialysis patients.

Performance of Cockcroft-Gault, MDRD, and CKD-EPI in estimating prevalence of renal function and predicting survival in the oldest old.

Mesenchymal stromal cells to prevent fibrosis in kidney transplantation.

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice.

Association of kidney function with changes in the endothelial surface layer.

A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography.

Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity.

Human Bone Marrow- and Adipose Tissue-derived Mesenchymal Stromal Cells are Immunosuppressive In vitro and in a Humanized Allograft Rejection Model.

Chronic kidney disease and implantable cardioverter defibrillator related complications: 16 years of experience.

Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion.

Associations of atherosclerosis in the descending thoracic aorta on CTA with arterial stiffness and chronic kidney disease in asymptomatic patients with diabetes mellitus.

Efficacy and safety of vitamin K-antagonists (VKA) for atrial fibrillation in non-dialysis dependent chronic kidney disease.

Telomere shortening: a diagnostic tool and therapeutic target for cardiovascular disease?

Islet-after-lung transplantation in a patient with cystic fibrosis-related diabetes.

MicroRNA-155 functions as a negative regulator of RhoA signaling in TGF-β-induced endothelial to mesenchymal transition.

Belimumab after rituximab as maintenance therapy in lupus nephritis.

Clinical translation of multipotent mesenchymal stromal cells in transplantation.

A case for crowd sourcing in stem cell research.

Erythropoiesis-stimulating agents and thrombotic events in dialysis patients.

The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases.

Tailoring the foreign body response for in situ vascular tissue engineering.

Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1.

Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients.

Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients.

Silencing of miRNA-126 in kidney ischemia reperfusion is associated with elevated SDF-1 levels and mobilization of Sca-1+/Lin- progenitor cells.

Guideline treatment results in regression of atherosclerosis in type 2 diabetes mellitus.

A microscopic view on the renal endothelial glycocalyx.

No increase in Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin excretion following intravenous contrast enhanced-CT.

Early systemic microvascular damage in pigs with atherogenic diabetes mellitus coincides with renal angiopoietin dysbalance.

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits.

Optimal predialysis care.

Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte.

Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study.

Candidate Gene Analysis of Mortality in Dialysis Patients.

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.

The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression.

Azathioprine-induced eosinophilic myocarditis in a patient with ANCA-associated vasculitis.

Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx.

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.

Is the prevalence of hypertension in overweight children overestimated?

Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation.

Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy.

Modelling the Cost-Effectiveness of Delaying End-Stage Renal Disease.

Macrophages in diabetic nephropathy in patients with type 2 diabetes.

Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model.

Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.

Cathepsin L is crucial for the development of early experimental diabetic nephropathy.

Promoting Tropoelastin Expression in Arterial and Venous Vascular Smooth Muscle Cells and Fibroblasts for Vascular Tissue Engineering.

Echocardiographic associates of atrial fibrillation in end-stage renal disease.

Mesenchymal stromal cells in clinical kidney transplantation: how tolerant can it be?

miRNA-Coordinated Networks as Promising Therapeutic Targets for Acute Kidney Injury.

RNA Contaminates Glycosaminoglycans Extracted from Cells and Tissues.

Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease.

Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy.

TAC-TIC use of tacrolimus-based regimens in lupus nephritis.

Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.

Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine.

Renal physiology: Burning calories to excrete salt.

The Cognitive decline in Older Patients with End stage renal disease (COPE) study - rationale and design.

Mesenchymal Stromal Cell Therapy for Solid Organ Transplantation.

Acute Rejection After Kidney Transplantation Associates With Circulating MicroRNAs and Vascular Injury.

Lupus nephritis: Mesenchymal stromal cells in lupus nephritis.

Self-Monitoring Kidney Function Post Transplantation: Reliability of Patient-Reported Data.

Metabolic imaging of fatty kidney in diabesity: validation and dietary intervention.

An evidence-based approach to pre-pregnancy counselling for patients with systemic lupus erythematosus.

Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease.

Randomized trial of one-hour sodium bicarbonate vs standard periprocedural saline hydration in chronic kidney disease patients undergoing cardiovascular contrast procedures.

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study.

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus.

MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.

Chronic kidney failure mineral bone disorder leads to a permanent loss of hematopoietic stem cells through dysfunction of the stem cell niche.

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium.

Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair.

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2.

Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases.

Prophylactic Use of Implantable Cardioverter-Defibrillators in the Prevention of Sudden Cardiac Death in Dialysis Patients.

Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.

Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Compared to Systemic Lupus Erythematosus.

Low Birth Weight and Kidney Function in Middle-Aged Men and Women: The Netherlands Epidemiology of Obesity Study.

New insights into energy and protein homeostasis by the kidney.

Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic miRNAs Between Extracellular Vesicles, HDL and Ago-2.

The Neglectable Impact of Delayed Graft Function on Long-term Graft Survival in Kidneys Donated After Circulatory Death Associates With Superior Organ Resilience.

The Separate Contributions of Visceral Fat and Liver Fat to Chronic Kidney Disease-Related Renal Outcomes.

Highly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cells.

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.

Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure.

Stem cell-derived kidney organoids: engineering the vasculature.

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.

Endothelial Glycocalyx Hyaluronan: Regulation and Role in Prevention of Diabetic Complications.

Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease: The Kompas Randomized Clinical Trial.

Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells induces formation of mature Weibel-Palade bodies.

Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia.

Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study.

Assessment of Size-Selective Glomerular Sieving in Transplanted Human Induced Pluripotent Stem Cell-Derived Kidney Organoids.

MicroRNA-132 regulates salt-dependent steady-state renin levels in mice.

Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results.

PR3-ANCAs predict relapses in ANCA-associated vasculitis patients after rituximab.

Dichotomic role of heparanase in a murine model of metabolic syndrome.

Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end-stage renal disease.

Highly Sensitive Flow Cytometric Detection of Residual B-Cells After Rituximab in Anti-Neutrophil Cytoplasmic Antibodies-Associated Vasculitis Patients.

Autologous bone marrow-derived mesenchymal stromal cell therapy with early tacrolimus withdrawal: The randomized prospective, single-center, open-label TRITON study.

The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial.

Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence.

Phenotypic diversity and metabolic specialization of renal endothelial cells.

Home monitoring reduced short stay admissions in suspected COVID-19 patients: COVID-box project.

Effectiveness of a multidisciplinary clinical pathway for women with systemic lupus erythematosus and/or antiphospholipid syndrome.

Imaging the Renal Microcirculation in Cell Therapy.

Thiol-ene cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition.

Microvascular differences in individuals with obesity at risk of developing cardiovascular disease.

Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452.

Thresholds of Endoglin Expression in Endothelial Cells Explains Vascular Etiology in Hereditary Hemorrhagic Telangiectasia Type 1.

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.

Clinical Practice Audit on the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in the Netherlands.

The association of glucose metabolism and kidney function in middle-aged adults.

Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity.

Blocking of inflammatory heparan sulfate domains by specific antibodies is not protective in experimental glomerulonephritis.

Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress.

Targeting the RNA-Binding Protein in Myeloid Cells Ameliorates Macrophage-Induced Renal Interstitial Fibrosis.

Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease.

Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier.

Will New Treatment Options for Lupus Nephritis Be Affordable?

Compassionate Use of Avacopan in Difficult-to-Treat Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit.

Large-scale engineering of hiPSC-derived nephron sheets and cryopreservation of their progenitors.

Toward Human Models of Cardiorenal Syndrome .

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.

Identifying relevant determinants of in-hospital time to diagnosis for ANCA-associated vasculitis patients.

COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study.

Vasculogenesis in kidney organoids upon transplantation.

Analyzing cell-type-specific dynamics of metabolism in kidney repair.

Development of Central Venous Stenosis Upon ICD Implantation in Dialysis Patients: A Non-Negligible Issue.

Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation.

Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial.

Ethnic differences in urinary monocyte chemoattractant protein-1 and heparanase-1 levels in individuals with type 2 diabetes: the HELIUS study.

Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids.

Preliminary Assessment of Safety and Tolerability of Avacopan During the Early Access Program for ANCA-Associated Vasculitis.

Response to "Tailored Use of Avacopan in a Case With Refractory Antineutrophil Cytoplasmic Autoantibody-Associated Renal Vasculitis and Concominant Complement System Activation".

Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuria.

Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes.

Altered high-density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross-sectional, case-control study on lipoprotein subclass profiling.

Sex-specific association between microvascular health and coagulation parameters: the Netherlands Epidemiology of Obesity study.

Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis.

Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis.

Cryopreservation breaks the organ transplant time barrier.

Unveiling the role of Mfsd2a and LPC-DHA in kidney repair.

Heart and kidney organoids maintain organ-specific function in a microfluidic system.

T-Cell Mediated Immune Rejection of Beta-2-Microglobulin Knockout Induced Pluripotent Stem Cell-Derived Kidney Organoids.

Endothelial to mesenchymal transition in kidney fibrosis.

Voclosporin and the Antiviral Effect Against SARS-CoV-2 in Immunocompromised Kidney Patients.

Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment.

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.

Ethnic Disparities in Lipid Metabolism and Clinical Outcomes between Dutch South Asians and Dutch White Caucasians with Type 2 Diabetes Mellitus.

Good Manufacturing Practice-compliant human induced pluripotent stem cells: from bench to putative clinical products.

Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands: A randomized controlled trial.

Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease.

Validating human induced pluripotent stem cell-specific quality control tests for the release of an intermediate drug product in a Good Manufacturing Practice quality system.

A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys.

Long-term renal and cardiovascular risks of tacrolimus in patients with lupus nephritis.

Clinical Remission and Reduction of Circulating Nephritic Factors by Combining Rituximab With Belimumab in a Case of Complement Factor 3 Glomerulopathy.

Spatial metabolomics in tissue injury and regeneration.

Application of spatial-omics to the classification of kidney biopsy samples in transplantation.