Brian C. Wilson

New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions.

Direct near-infrared luminescence detection of singlet oxygen generated by photodynamic therapy in cells in vitro and tissues in vivo.

Photodynamic therapy for cancer: principles.

Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancers.

A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumors.

Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polyps.

Potential applications of photodynamic therapy in regenerative medicine.

In vivo Doppler optical coherence tomography of mucocutaneous telangiectases in hereditary hemorrhagic telangiectasia.

Molecular fluorescence excitation-emission matrices relevant to tissue spectroscopy.

In vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy.

Radiance-based monitoring of the extent of tissue coagulation during laser interstitial thermal therapy.

Effects of Pd-bacteriopheophorbide (TOOKAD)-mediated photodynamic therapy on canine prostate pretreated with ionizing radiation.

Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy.

Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: rationale and preclinical evaluation of technical feasibility for treating malignant brain tumors.

Micromachined array tip for multifocus fiber-based optical coherence tomography.

Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy.

Protease-triggered photosensitizing beacon based on singlet oxygen quenching and activation.

Assessment of cutaneous photosensitivity of TOOKAD (WST09) in preclinical animal models and in patients.

Autofluorescence-based detection of early neoplasia in patients with Barrett's esophagus.

Increased brain tumor resection using fluorescence image guidance in a preclinical model.

The potential of autofluorescence for the detection of single living cells for label-free cell sorting in microfluidic systems.

Optical techniques for the endoscopic detection of dysplastic colonic lesions.

The microenvironment effect on the generation of reactive oxygen species by Pd-bacteriopheophorbide.

Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer.

Imaging of photodynamically generated singlet oxygen luminescence in vivo.

Fluorescence image-guided brain tumour resection with adjuvant metronomic photodynamic therapy: pre-clinical model and technology development.

Techniques for delivery and monitoring of TOOKAD (WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities.

Endoscopic Doppler optical coherence tomography in the human GI tract: initial experience.

Relaxin pretreatment decreases infarct size in male rats after middle cerebral artery occlusion.

Relaxin inhibits central angiotensin II expression in killifish: a central osmoregulatory role for relaxin and angiotensin II in the killifish Fundulus heteroclitus.

Interstitial Doppler optical coherence tomography.

Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms.

Endoscopic detection of early upper GI cancers.

Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis.

Spectroscopy and fluorescence in esophageal diseases.

Photodynamic therapy for urological malignancies: past to current approaches.

Simultaneous two-photon excitation of photofrin in relation to photodynamic therapy.

Doppler optical coherence tomography with a micro-electro-mechanical membrane mirror for high-speed dynamic focus tracking.

Photodynamic therapy of brain tumors--a work in progress.

Magnetic resonance imaging correlated with the histopathological effect of Pd-bacteriopheophorbide (Tookad) photodynamic therapy on the normal canine prostate gland.

Singlet oxygen luminescence dosimetry (SOLD) for photodynamic therapy: current status, challenges and future prospects.

Multimodality imaging for vertebral metastases in a rat osteolytic model.

Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy.

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals.

Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy.

Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy.

A new technique for physiodesis using photodynamic therapy.

Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation.

Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation.

Prostate gland: MR imaging appearance after vascular targeted photodynamic therapy with palladium-bacteriopheophorbide.

Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions.

Complete blood vessel occlusion in the chick chorioallantoic membrane using two-photon excitation photodynamic therapy: implications for treatment of wet age-related macular degeneration.

Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus.

Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma.

Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedside.

Quantitative in vitro demonstration of two-photon photodynamic therapy using photofrin and visudyne.

Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy.

δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.

Using the singlet oxygen scavenging property of carotenoid in photodynamic molecular beacons to minimize photodamage to non-targeted cells.

The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues--in vivo study in a canine model.

Fluorescence and spectral imaging.

Effect of dimerization on vibrational spectra of eumelanin precursors.

The physics, biophysics and technology of photodynamic therapy.

Vascular-targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light doses.

The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro.

Speckle variance detection of microvasculature using swept-source optical coherence tomography.

A tumor mRNA-triggered photodynamic molecular beacon based on oligonucleotide hairpin control of singlet oxygen production.

Relaxin-3 and RXFP3 expression, and steroidogenic actions in the ovary of teleost fish.

Intravital high-resolution optical imaging of individual vessel response to photodynamic treatment.

Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study.

One- and two-photon activated phototoxicity of conjugated porphyrin dimers with high two-photon absorption cross sections.

Proof-of-principle demonstration of a Mueller matrix decomposition method for polarized light tissue characterization in vivo.

Defining the therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin).

Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer.

Mueller matrix decomposition for polarized light assessment of biological tissues.

Relaxin family genes in humans and teleosts.

An in vitro study of the protective effect of relaxin on brain tissue under ischemic stress.

Fluorescence and Raman spectroscopy.

Head & neck optical diagnostics: vision of the future of surgery.

Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI.

FRET quenching of photosensitizer singlet oxygen generation.

Feasibility study of autofluorescence mammary ductoscopy.

"Zipper" molecular beacons: a generalized strategy to optimize the performance of activatable protease probes.

The potential of biophotonic techniques in stem cell tracking and monitoring of tissue regeneration applied to cardiac stem cell therapy.

Autofluorescence-guided surveillance for oral cancer.

Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis.

Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex.

Drug and light dose responses to focal photodynamic therapy of single blood vessels in vivo.

Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue.

Effects of photodynamic therapy on the structural integrity of vertebral bone.

Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract.

Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.

A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients.

Optimized speckle variance OCT imaging of microvasculature.

Prostate tissue composition and MR measurements: investigating the relationships between ADC, T2, K(trans), v(e), and corresponding histologic features.

Facile synthesis of advanced photodynamic molecular beacon architectures.

Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancer.

Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus.

Polarization birefringence measurements for characterizing the myocardium, including healthy, infarcted, and stem-cell-regenerated tissues.

Inter-related in vitro effects of androgens, fatty acids and oxidative stress in prostate cancer: a mechanistic model supporting prevention strategies.

Facile synthesis of Raman active phospholipid gold nanoparticles.

The influence of oxygen depletion and photosensitizer triplet-state dynamics during photodynamic therapy on accurate singlet oxygen luminescence monitoring and analysis of treatment dose response.

Topographic mapping of subsurface fluorescent structures in tissue using multiwavelength excitation.

Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements.

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.

Homogenized tissue phantoms for quantitative evaluation of subsurface fluorescence contrast.

At the frontiers of surgery: review.

Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.

Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.

Imaging of specific activation of photodynamic molecular beacons in breast cancer vertebral metastases.

Photodynamic therapy of cancer: an update.

The future of medical diagnostics: review paper.

Multimodal bacteriochlorophyll theranostic agent.

Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer.

Nonlinear optical properties of type I collagen fibers studied by polarization dependent second harmonic generation microscopy.

Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery.

Insights into photodynamic therapy dosimetry: simultaneous singlet oxygen luminescence and photosensitizer photobleaching measurements.

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.

Estimation of minimum doses for optimized quantum dot contrast-enhanced vascular imaging in vivo.

Effect of tissue optics on wavelength optimization for quantum dot-based surface and subsurface fluorescence imaging.

Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility.

Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models.

Biodistribution and pharmacokinetic studies of a porphyrin dimer photosensitizer (Oxdime) by fluorescence imaging and spectroscopy in mice bearing xenograft tumors.

Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid).

Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model.

Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit.

Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties.

Porphyrin-lipid stabilized gold nanoparticles for surface enhanced Raman scattering based imaging.

Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.

Filter-based method for background removal in high-sensitivity wide-field-surface-enhanced Raman scattering imaging in vivo.

Feasibility study on quantitative measurements of singlet oxygen generation using singlet oxygen sensor green.

Adjuncts for maximizing resection: 5-aminolevuinic acid.

Diffuse reflectance spectroscopy in Barrett's esophagus: developing a large field-of-view screening method discriminating dysplasia from metaplasia.

Quantitative, spectrally-resolved intraoperative fluorescence imaging.

Intrinsically copper-64-labeled organic nanoparticles as radiotracers.

Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue.

Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector.

Inherently multimodal nanoparticle-driven tracking and real-time delineation of orthotopic prostate tumors and micrometastases.

Widefield quantitative multiplex surface enhanced Raman scattering imaging in vivo.

The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy.

Biologically-targeted detection of primary and micro-metastatic ovarian cancer.

5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.

System and methods for wide-field quantitative fluorescence imaging during neurosurgery.

Optical glucose analogs of aminolevulinic acid for fluorescence-guided tumor resection and photodynamic therapy.

Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors.

Evaluation of one- and two-photon activated photodynamic therapy with pyropheophorbide-a methyl ester in human cervical, lung and ovarian cancer cells.

Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic, and fluorescence imaging.

High-resolution angioscopic imaging during endovascular neurosurgery.

Orthotopic lung cancer murine model by nonoperative transbronchial approach.

Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy.

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

Rapid ratiometric biomarker detection with topically applied SERS nanoparticles.

Wide-field multiplexed imaging of EGFR-targeted cancers using topical application of NIR SERS nanoprobes.

Stimuli-responsive photoacoustic nanoswitch for in vivo sensing applications.

Tetherless fiber-coupled optical sources for extended metronomic photodynamic therapy.

Interstitial in vivo ALA-PpIX mediated metronomic photodynamic therapy (mPDT) using the CNS-1 astrocytoma with bioluminescence monitoring.

Autofluorescence and Photofrin-induced fluorescence imaging and spectroscopy in an animal model of oral cancer.

In vitro and in vivo effects of photodynamic therapy on metastatic breast cancer cells pre-treated with zoledronic acid.

Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy.

Advances in engineering of high contrast CARS imaging endoscopes.

Dynamic contrast enhanced MRI as a predictor of vascular-targeted photodynamic focal ablation therapy outcome in prostate cancer post-failed external beam radiation therapy.

Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.

Activation kinetics of zipper molecular beacons.

Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance.

Sub-diffuse interstitial optical tomography to improve the safety of brain needle biopsies: a proof-of-concept study.

Nano-enabled SERS reporting photosensitizers.

Point-of-care autofluorescence imaging for real-time sampling and treatment guidance of bioburden in chronic wounds: first-in-human results.

Macroscopic-imaging technique for subsurface quantification of near-infrared markers during surgery.

In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging.

A prototype hand-held tri-modal instrument for in vivo ultrasound, photoacoustic, and fluorescence imaging.

Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.

Ultrastructural features of collagen in thyroid carcinoma tissue observed by polarization second harmonic generation microscopy.

Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report.

Sensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures.

Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.

Improved sensitivity to fluorescence for cancer detection in wide-field image-guided neurosurgery.

Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging.

X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield.

A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system.

Photosensitized singlet oxygen generation and detection: Recent advances and future perspectives in cancer photodynamic therapy.

Nanoparticle-enabled selective destruction of prostate tumor using MRI-guided focal photothermal therapy.

Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography.

Controlling Spatial Heat and Light Distribution by Using Photothermal Enhancing Auto-Regulated Liposomes (PEARLs).

A compact fiber-optic probe-based singlet oxygen luminescence detection system.

An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer.

Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study.

A review of Raman spectroscopy advances with an emphasis on clinical translation challenges in oncology.

Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy.