Kobayashi Hisataka

Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft.

Improved renal clearance and tumor targeting of 99mTc-labeled anti-Tac monoclonal antibody Fab by chemical modifications.

Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256).

Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation.

Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent.

Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates.

Dynamic micro-MRI of liver micrometastasis with a novel liver macromolecular MR contrast agent DAB-Am64-(1B4M-Gd)64.

Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents.

Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent.

Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.

Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification.

Detection of inflammation following renal ischemia by magnetic resonance imaging.

Inflammatory breast cancer: vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model.

Dendrimer-based macromolecular MRI contrast agents: characteristics and application.

Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose.

Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase.

Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.

Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography.

Uterine peristalsis shown on cine MR imaging using ultrafast sequence.

Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.

Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex.

Micro-MRI methods to detect renal cysts in mice.

Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.

Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure.

Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.

Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.

Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.

Dendrimer-based nanosized MRI contrast agents.

Posterior cul-de-sac obliteration associated with endometriosis: MR imaging evaluation.

Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.

Nano-sized MRI contrast agents with dendrimer cores.

Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.

Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.

Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents.

Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.

In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent.

Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin.

Macromolecular MRI contrast agents for imaging tumor angiogenesis.

Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity.

A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells.

Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location.

Imaging of the lymphatic system: new horizons.

MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.

[Molecular imaging; current status and future prospects in USA].

Glucose 1-phosphate increases active transport of calcium in intestine.

A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.

An enzymatically activated fluorescence probe for targeted tumor imaging.

A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate.

Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody.

Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms.

Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu.

Two-color lymphatic mapping using Ig-conjugated near infrared optical probes.

Simultaneous multicolor imaging of five different lymphatic basins using quantum dots.

Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.

Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging.

Reduction of Streptococcus mutans adherence and dental biofilm formation by surface treatment with phosphorylated polyethylene glycol.

Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.

Targeted optical fluorescence imaging of human ovarian adenocarcinoma using a galactosyl serum albumin-conjugated fluorophore.

A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a "smart" fluorescent molecular imaging probe synthesized with clinically applicable material for detecting peritoneal ovarian cancer metastases.

In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.

Tumor-targeted optical imaging in the management of peritoneal carcinomatosis.

D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green.

[In-vivo cancer fluorescence imaging with novel precisely-designed fluorescence probes].

In vivo molecular imaging to diagnose and subtype tumors through receptor-targeted optically labeled monoclonal antibodies.

Multiplexing with multispectral imaging: from mice to microscopy.

Determination of optimal rhodamine fluorophore for in vivo optical imaging.

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.

Differentiation of bacterial and non-bacterial community-acquired pneumonia by thin-section computed tomography.

Dendrimer-based contrast agents for molecular imaging.

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes.

Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "quencher-chaser": a dual "quench and chase" strategy to improve target to nontarget ratios for molecular imaging of cancer.

Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging.

In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies.

Dendrimers in medical nanotechnology.

In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green.

Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer.

Multicolor in vivo targeted imaging to guide real-time surgery of HER2-positive micrometastases in a two-tumor coincident model of ovarian cancer.

H-type dimer formation of fluorophores: a mechanism for activatable, in vivo optical molecular imaging.

Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents.

In vivo stable tumor-specific painting in various colors using dehalogenase-based protein-tag fluorescent ligands.

In vivo real-time, multicolor, quantum dot lymphatic imaging.

Imaging of tumor angiogenesis: functional or targeted?

Fluorescence imaging of tumors with "smart" pH-activatable targeted probes.

Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases.

Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers.

Molecular probes for the in vivo imaging of cancer.

Clinical implications of near-infrared fluorescence imaging in cancer.

Dual-modality molecular imaging using antibodies labeled with activatable fluorescence and a radionuclide for specific and quantitative targeted cancer detection.

Semiquantitative assessment of the microdistribution of fluorescence-labeled monoclonal antibody in small peritoneal disseminations of ovarian cancer.

New strategies for fluorescent probe design in medical diagnostic imaging.

Toxicity of organic fluorophores used in molecular imaging: literature review.

Nanoparticles in sentinel lymph node mapping.

Fluorescence lifetime imaging of activatable target specific molecular probes.

Two-step synthesis of galactosylated human serum albumin as a targeted optical imaging agent for peritoneal carcinomatosis.

New approaches to lymphatic imaging.

New nanosized biocompatible MR contrast agents based on lysine-dendri-graft macromolecules.

Multiplexed imaging in cancer diagnosis: applications and future advances.

In vivo molecular imaging using nanomaterials: general in vivo characteristics of nano-sized reagents and applications for cancer diagnosis.

High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation.

Real-time optical imaging using quantum dot and related nanocrystals.

Biodistribution and excretion of monosaccharide-albumin conjugates measured with in vivo near-infrared fluorescence imaging.

Optimizing quantitative in vivo fluorescence imaging with near-infrared quantum dots.

A portable fluorescence camera for testing surgical specimens in the operating room: description and early evaluation.

Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models.

Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications.

Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle.

In vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system.

Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green.

Biologically optimized nanosized molecules and particles: more than just size.

Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics.

Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals.

Efficient access to a dihydropyran-containing macrolide via a transannular oxy-Michael reaction: total synthesis of (+)-aspergillide C.

Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate.

Molecular imaging of tumor invasion and metastases: the role of MRI.

Activatable optical imaging with a silica-rhodamine based near infrared (SiR700) fluorophore: a comparison with cyanine based dyes.

Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.

Rapid cancer detection by topically spraying a γ-glutamyltranspeptidase-activated fluorescent probe.

Recipe for a new imaging biomarker: carefully combine target, reagent, and technology.

Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate.

MR imaging biomarkers for evaluating therapeutic effects shortly after near infrared photoimmunotherapy.

MR and optical imaging of early micrometastases in lymph nodes: triple labeling with nano-sized agents yielding distinct signals.

In vivo breast cancer characterization imaging using two monoclonal antibodies activatably labeled with near infrared fluorophores.

Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe.

The use of fluorescent proteins for developing cancer-specific target imaging probes.

Galactosyl human serum albumin-NMP1 conjugate: a near infrared (NIR)-activatable fluorescence imaging agent to detect peritoneal ovarian cancer metastases.

Real-time monitoring of in vivo acute necrotic cancer cell death induced by near infrared photoimmunotherapy using fluorescence lifetime imaging.

Quantitative and specific molecular imaging of cancer with labeled engineered monoclonal antibody fragments.

Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy.

Gadolinium MRI Contrast Agents Based on Triazine Dendrimers: Relaxivity and In Vivo Pharmacokinetics.

In vivo real-time lymphatic draining using quantum-dot optical imaging in mice.

Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors.

Polychromatic in vivo imaging of multiple targets using visible and near infrared light.

Optical imaging of HPV infection in a murine model.

Acute cytotoxic effects of photoimmunotherapy assessed by 18F-FDG PET.

Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes.

Monoclonal antibody-fluorescent probe conjugates for in vivo target-specific cancer imaging: toward clinical translation.

Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging.

Improving the efficacy of Photoimmunotherapy (PIT) using a cocktail of antibody conjugates in a multiple antigen tumor model.

Endoscopic molecular imaging of cancer.

MR lymphangiography with intradermal gadofosveset and human serum albumin in mice and primates.

Dendrimers as high relaxivity MR contrast agents.

The effect of photoimmunotherapy followed by liposomal daunorubicin in a mixed tumor model: a demonstration of the super-enhanced permeability and retention effect after photoimmunotherapy.

Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?

Activatable organic near-infrared fluorescent probes based on a bacteriochlorin platform: synthesis and multicolor in vivo imaging with a single excitation.

Fluorescence-lifetime molecular imaging can detect invisible peritoneal ovarian tumors in bloody ascites.

Magnetic resonance lymphography of the thoracic duct after interstitial injection of gadofosveset trisodium: a pilot dosing study in a porcine model.

Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor.

Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission.

Dynamic fluorescent imaging with indocyanine green for monitoring the therapeutic effects of photoimmunotherapy.

The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity.

Minibody-indocyanine green based activatable optical imaging probes: the role of short polyethylene glycol linkers.

Analysis of biodistribution of intracranially infused radiolabeled interleukin-13 receptor-targeted immunotoxin IL-13PE by SPECT/CT in an orthotopic mouse model of human glioma.

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography.

Cancer drug delivery: considerations in the rational design of nanosized bioconjugates.

Preparation and long-term biodistribution studies of a PAMAM dendrimer G5-Gd-BnDOTA conjugate for lymphatic imaging.

Photoimmunotherapy of gastric cancer peritoneal carcinomatosis in a mouse model.

Near infrared photoimmunotherapy in the treatment of disseminated peritoneal ovarian cancer.

Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies?

Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2-negative breast cancer cells.

Magnetic resonance sentinel lymph node imaging of the prostate with gadofosveset trisodium-albumin: preliminary results in a canine model.

Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo.

Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

Photoimmunotherapy lowers recurrence after pancreatic cancer surgery in orthotopic nude mouse models.

Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine.

Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.

Near infrared photoimmunotherapy in the treatment of pleural disseminated NSCLC: preclinical experience.

Photoimmunotherapy of hepatocellular carcinoma-targeting Glypican-3 combined with nanosized albumin-bound paclitaxel.

Glypican-3 targeted human heavy chain antibody as a drug carrier for hepatocellular carcinoma therapy.

Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model.

Ferumoxytol as an intraprostatic MR contrast agent for lymph node mapping of the prostate: a feasibility study in non-human primates.

Near infrared photoimmunotherapy for lung metastases.

Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green.

Impact of C4'-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates.

Near Infrared Photoimmunotherapy Targeting EGFR Positive Triple Negative Breast Cancer: Optimizing the Conjugate-Light Regimen.

Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages.

Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy.

Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates.

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.

Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer.

Comparative effectiveness of light emitting diodes (LEDs) and Lasers in near infrared photoimmunotherapy.

Combination photoimmunotherapy with monoclonal antibodies recognizing different epitopes of human epidermal growth factor receptor 2: an assessment of phototherapeutic effect based on fluorescence molecular imaging.