Marc Symons

Microglial stimulation of glioblastoma invasion involves EGFR and CSF-1R signaling.

Regulation of microtubule stability and mitotic progression by survivin.

Role of Rho family GTPases in epithelial morphogenesis.

Cell motility and invasion assays.

Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis.

Control of vesicular trafficking by Rho GTPases.

Cyclin D1 governs adhesion and motility of macrophages.

Regulation of migration of primary prostate epithelial cells by secreted factors from prostate stromal cells.

Modulation of Rac localization and function by dynamin.

Molecular basis for Rho GTPase signaling specificity.

Regulation of anoikis by Cdc42 and Rac1.

Role of synaptojanin 2 in glioma cell migration and invasion.

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.

Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection.

Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1.

Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages.

Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.

Cell migration and invasion assays.

Molecular pathways triggering glioma cell invasion.

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.

The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration.

Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas.

The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.

Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas.

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.

The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts.

Cell biology: watching the first steps of podosome formation.

The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

Rac and Rho driving tumor invasion: who's at the wheel?

Role of Rac1-regulated signaling in medulloblastoma invasion. Laboratory investigation.

Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.

Phosphoinositides direct equine infectious anemia virus gag trafficking and release.

The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy.

Rac1 activation comes full circle.

Glioblastoma with PNET-like components has a higher frequency of isocitrate dehydrogenase 1 (IDH1) mutation and likely a better prognosis than primary glioblastoma.

Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion.

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.

Signaling determinants of glioma cell invasion.

The small GTPase RhoG mediates glioblastoma cell invasion.

Regulation of synaptojanin 2 5'-phosphatase activity by Src.

The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion.

The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.

Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.

The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.

Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia.

Repurposing mebendazole for the treatment of medulloblastoma.

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.

Celecoxib inhibits Ewing sarcoma cell migration via actin modulation.

The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation.

SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.

Neuro-oncology biotech industry progress report.

Radioresistance of Brain Tumors.

Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma.

Curcumin changes the polarity of tumor-associated microglia and eliminates glioblastoma.