Alessandro Sacchetti

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines.

Total enantioselective synthesis of (-)-cytisine.

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

An efficient enantioselective approach to cyclic beta-amino acid derivatives via olefin metathesis reactions.

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

Pyrroloisoquinoline-based tetrapeptide analogues mimicking reverse-turn secondary structures.

Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.

Olefin metathesis based approach to diversely functionalized pyrrolizidines and indolizidines; total synthesis of (+)-monomorine.

Grignard addition to imines derived from isatine: a method for the asymmetric synthesis of quaternary 3-aminooxindoles.

Tetrahydroisoquinoline-based spirocyclic lactam as a type II' beta-turn inducing peptide mimetic.

Phe-Ala-based diazaspirocyclic lactam as nucleator of type II' β-turn.

Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin.

Productivity enhancement of C=C bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes.

Ugi 4-CR/Pictet-Spengler reaction as a short route to tryptophan-derived peptidomimetics.

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues.

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.

Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.

Substrate scope and synthetic applications of the enantioselective reduction of α-alkyl-β-arylenones mediated by Old Yellow Enzymes.

Synthesis of robalzotan, ebalzotan, and rotigotine precursors via the stereoselective multienzymatic cascade reduction of α,β-unsaturated aldehydes.

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins.

Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation.

Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics.

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives.

Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.

Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.

A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury.

Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin.

Tunable drug delivery using chemoselective functionalization of hydrogels.

Spectroscopic, Structural, and Computational Characterization of Three Bispidinone Derivatives, as Ligands for Enantioselective Metal Catalyzed Reactions.

Organocatalytic vinylogous Mannich reaction of trimethylsiloxyfuran with isatin-derived benzhydryl-ketimines.