Michael Fehlings

Myelopathy and spinal deformity: relevance of spinal alignment in planning surgical intervention for degenerative cervical myelopathy.

Meeting the privacy requirements for the development of a multi-centre patient registry in Canada: the Rick Hansen Spinal Cord Injury Registry.

AOSpine thoracolumbar spine injury classification system: fracture description, neurological status, and key modifiers.

Mild diabetes is not a contraindication for surgical decompression in cervical spondylotic myelopathy: results of the AOSpine North America multicenter prospective study (CSM).

Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model.

Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27.

A summary of assessment tools for patients suffering from cervical spondylotic myelopathy: a systematic review on validity, reliability and responsiveness.

Spinal cord injury: Visualizing plasticity and repair in the injured CNS.

Modeling the patient journey from injury to community reintegration for persons with acute traumatic spinal cord injury in a Canadian centre.

Cervical spondylotic myelopathy: methodological approaches to evaluate the literature and establish best evidence.

Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study.

A clinical prediction model to determine outcomes in patients with cervical spondylotic myelopathy undergoing surgical treatment: data from the prospective, multi-center AOSpine North America study.

Predictors of outcome in patients with cervical spondylotic myelopathy undergoing surgical treatment: a survey of members from AOSpine International.

Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy.

Anterior versus posterior surgical approaches to treat cervical spondylotic myelopathy: outcomes of the prospective multicenter AOSpine North America CSM study in 264 patients.

Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration.

Riluzole attenuates neuropathic pain and enhances functional recovery in a rodent model of cervical spondylotic myelopathy.

The SCIentinel study--prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS)--study protocol and interim feasibility data.

Defining age-related differences in outcome after traumatic spinal cord injury: analysis of a combined, multicenter dataset.

Characterization of vascular disruption and blood-spinal cord barrier permeability following traumatic spinal cord injury.

Cervical spondylotic myelopathy: an update: editorial.

Hypoxic locomotor rehabilitation for incomplete spinal cord injury: not an oxymoron.

Effect of type II odontoid fracture nonunion on outcome among elderly patients treated without surgery: based on the AOSpine North America geriatric odontoid fracture study.

The role of neural precursor cells and self assembling peptides in nerve regeneration.

Comparative effectiveness of surgical versus nonoperative management of unilateral, nondisplaced, subaxial cervical spine facet fractures without evidence of spinal cord injury: clinical article.

Synergistic effects of self-assembling peptide and neural stem/progenitor cells to promote tissue repair and forelimb functional recovery in cervical spinal cord injury.

Canine notochordal cell-secreted factors protect murine and human nucleus pulposus cells from apoptosis by inhibition of activated caspase-9 and caspase-3/7.

A novel scientific model for rare and often neglected neoplastic conditions.

Increased expression of CD25, CD83, and CD86, and secretion of IL-12, IL-23, and IL-10 by human dendritic cells incubated in the presence of Toll-like receptor 2 ligands and Giardia duodenalis.

Health state utility of patients with single-level cervical degenerative disc disease: comparison of anterior cervical discectomy and fusion with cervical disc arthroplasty.

Reliability of the Spinal Instability Neoplastic Score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases.

Lateral mass screw fixation in the cervical spine.

Perceived facilitators and barriers to self-management in individuals with traumatic spinal cord injury: a qualitative descriptive study.

Pathobiology of cervical spondylotic myelopathy.

The timing of decompressive spinal surgery in cauda equina syndrome.

Treatment of spinal cord injury with intravenous immunoglobulin G: preliminary evidence and future perspectives.

Improving access to emergent spinal care through knowledge translation: an ethnographic study.

Minimizing errors in acute traumatic spinal cord injury trials by acknowledging the heterogeneity of spinal cord anatomy and injury severity: an observational Canadian cohort analysis.

Very high resolution ultrasound imaging for real-time quantitative visualization of vascular disruption after spinal cord injury.

Delayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury.

Do quantitative magnetic resonance imaging parameters correlate with the clinical presentation and functional outcomes after surgery in cervical spondylotic myelopathy? A prospective multicenter study.

Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease.

Bilateral contusion-compression model of incomplete traumatic cervical spinal cord injury.

Timing of surgery in thoracolumbar trauma: is early intervention safe?

Operative and nonoperative adverse events in the management of traumatic fractures of the thoracolumbar spine: a systematic review.

Methylprednisolone for the treatment of acute spinal cord injury: counterpoint.

Pneumocephalus: an unusual case of postoperative seizure after intradural spine surgery.

Cost-effectiveness of surgery in the management of metastatic epidural spinal cord compression: a systematic review.

Consensus statement: systematic reviews of value-based surgical spine care: what do we know? Where are the limitations?

Clinical registries and evidence-based care pathways: raising the bar for meaningful measurement and delivery of value-based care.

Changes in gap junction expression and function following ischemic injury of spinal cord white matter.

Neural precursor cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive/contusive cervical spinal cord injury.

Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury.

Community engagement and knowledge translation: progress and challenge in autism research.

Adult-onset syringomyelia: from theory to practice and beyond.

Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture.

In response.

An evidence-based medicine model for rare and often neglected neoplastic conditions.

Outcome of the upper limb in cervical spinal cord injury: Profiles of recovery and insights for clinical studies.

Reliability of the spinal instability neoplastic scale among radiologists: an assessment of instability secondary to spinal metastases.

Global prevalence and incidence of traumatic spinal cord injury.

Introduction to focus issue.

Background to understanding value-based surgical spine care.

Is minimal access spine surgery more cost-effective than conventional spine surgery?

More "why" and less "how": is value-based spine care the next breakthrough?

Views of people with traumatic spinal cord injury about the components of self-management programs and program delivery: a Canadian pilot study.

Neurological outcomes of animal models of uterine artery ligation and relevance to human intrauterine growth restriction: a systematic review.

The influence of time from injury to surgery on motor recovery and length of hospital stay in acute traumatic spinal cord injury: an observational Canadian cohort study.

Association of preoperative cervical spine alignment with spinal cord magnetic resonance imaging hyperintensity and myelopathy severity: analysis of a series of 124 cases.

Psychometric properties of the modified Japanese Orthopaedic Association scale in patients with cervical spondylotic myelopathy.

Examination of the combined effects of chondroitinase ABC, growth factors and locomotor training following compressive spinal cord injury on neuroanatomical plasticity and kinematics.

Incidence, impact, and risk factors of adverse events in thoracic and lumbar spine fractures: an ambispective cohort analysis of 390 patients.

Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival.

A clinical prediction model to assess surgical outcome in patients with cervical spondylotic myelopathy: internal and external validations using the prospective multicenter AOSpine North American and international datasets of 743 patients.

Towards the development of an outcome instrument for spinal trauma: an international survey of spinal surgeons.

Reliability analysis of the AOSpine thoracolumbar spine injury classification system by a worldwide group of naïve spinal surgeons.

Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from Phase I to II.

Ankylosing spinal disorders--falls, flawed flexibility, and fixations.

Role of magnetic resonance imaging in predicting surgical outcome in patients with cervical spondylotic myelopathy.

An Assessment of the Key Predictors of Perioperative Complications in Patients with Cervical Spondylotic Myelopathy Undergoing Surgical Treatment: Results from a Survey of 916 AOSpine International Members.

AOSpine subaxial cervical spine injury classification system.

Prophylactic dexamethasone effectively reduces the incidence of pain flare following spine stereotactic body radiotherapy (SBRT): a prospective observational study.

Development and implementation of guidelines in neurosurgery.

Magnetic resonance imaging assessment of spinal cord and cauda equina motion in supine patients with spinal metastases planned for spine stereotactic body radiation therapy.

Degenerative Cervical Myelopathy: Epidemiology, Genetics, and Pathogenesis.

Establishing the injury severity of thoracolumbar trauma: confirmation of the hierarchical structure of the AOSpine Thoracolumbar Spine Injury Classification System.

Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury.

High-resolution imaging of the central nervous system: how novel imaging methods combined with navigation strategies will advance patient care.

Does Magnetic Resonance Imaging Improve the Predictive Performance of a Validated Clinical Prediction Rule Developed to Evaluate Surgical Outcome in Patients With Degenerative Cervical Myelopathy?

Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside.

The surgical algorithm for the AOSpine thoracolumbar spine injury classification system.

Craniocervical deformity and myelopathy after chronic odontoid fracture.

Transplantation of Induced Pluripotent Stem Cell-Derived Neural Stem Cells Mediate Functional Recovery Following Thoracic Spinal Cord Injury Through Remyelination of Axons.

A global perspective on the outcomes of surgical decompression in patients with cervical spondylotic myelopathy: results from the prospective multicenter AOSpine international study on 479 patients.

Spontaneous resolution of idiopathic thoracic spinal cord herniation: case report.

Spinal hemangiomas: results of surgical management for local recurrence and mortality in a multicenter study.

Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Propensity Score-Matched Cohort Study from a Canadian Multi-Center Spinal Cord Injury Registry.

Acute Spinal Cord Injury.

Effect of older age on treatment decisions and outcomes among patients with traumatic spinal cord injury.

Treatment of Axis Body Fractures: A Systematic Review.

Prediction of Quality of Life and Survival After Surgery for Symptomatic Spinal Metastases: A Multicenter Cohort Study to Determine Suitability for Surgical Treatment.

Prevalence of Klippel-Feil Syndrome in a Surgical Series of Patients with Cervical Spondylotic Myelopathy: Analysis of the Prospective, Multicenter AOSpine North America Study.

Can a Thoracolumbar Injury Severity Score Be Uniformly Applied from T1 to L5 or Are Modifications Necessary?

Assessment of impact of standing long-cassette radiographs on surgical planning for lumbar pathology: an international survey of spine surgeons.

The Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and Challenges.

Reliability assessment of a novel cervical spine deformity classification system.

Impact of dynamic alignment, motion, and center of rotation on myelopathy grade and regional disability in cervical spondylotic myelopathy.

Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury.

Toward developing a specific outcome instrument for spine trauma: an empirical cross-sectional multicenter ICF-based study by AOSpine Knowledge Forum Trauma.

Novel Method Using Baseline Normalization and Area Under the Curve to Evaluate Differences in Outcome Between Treatment Groups and Application to Patients With Cervical Spondylotic Myelopathy Undergoing Anterior Versus Posterior Surgery.

The Aging of the Global Population: The Changing Epidemiology of Disease and Spinal Disorders.

Minimally Invasive Spinal Surgery in the Elderly: Does It Make Sense?

A Cost-Utility Analysis of Lumbar Decompression With and Without Fusion for Degenerative Spine Disease in the Elderly.

Optimal Timing of Surgical Decompression for Acute Traumatic Central Cord Syndrome: A Systematic Review of the Literature.

Impact of Movement Disorders on Management of Spinal Deformity in the Elderly.

The Burden of Spinal Disorders in the Elderly.

Degenerative Cervical Myelopathy: A Spectrum of Related Disorders Affecting the Aging Spine.

Degenerative Spinal Deformity.

Salvage Stereotactic Body Radiotherapy (SBRT) Following In-Field Failure of Initial SBRT for Spinal Metastases.

Iatrogenic neurologic deficit after lumbar spine surgery: A review.

A systematic review of clinical and surgical predictors of complications following surgery for degenerative cervical myelopathy.

The Association of Cervical Spine Alignment with Neurologic Recovery in a Prospective Cohort of Patients with Surgical Myelopathy: Analysis of a Series of 124 Cases.

A New Acute Impact-Compression Lumbar Spinal Cord Injury Model in the Rodent.

Does age affect surgical outcomes in patients with degenerative cervical myelopathy? Results from the prospective multicenter AOSpine International study on 479 patients.

Complications from the use of intrawound vancomycin in lumbar spinal surgery: a systematic review.

Unintended durotomy in lumbar degenerative spinal surgery: a 10-year systematic review of the literature.

A Worldwide Analysis of the Reliability and Perceived Importance of an Injury to the Posterior Ligamentous Complex in AO Type A Fractures.

Spinal Cord Segmentation by One Dimensional Normalized Template Matching: A Novel, Quantitative Technique to Analyze Advanced Magnetic Resonance Imaging Data.

Is there a regional difference in morphology interpretation of A3 and A4 fractures among different cultures?

The Minimum Clinically Important Difference of the Modified Japanese Orthopaedic Association Scale in Patients with Degenerative Cervical Myelopathy.

Treatment of isolated cervical facet fractures: a systematic review.

Reply to the letter to the editor regarding "A clinical prediction model to assess surgical outcome in patients with cervical spondylotic myelopathy: internal and external validation using the prospective multicenter AOSpine North American and International datasets of 743 patients." Spine J 2015;15:388-397.

Commentary: Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord.

Toward the Development of a Universal Outcome Instrument for Spine Trauma: A Systematic Review and Content Comparison of Outcome Measures Used in Spine Trauma Research Using the ICF as Reference.

Risk Factors for Recurrence of Surgically Treated Conventional Spinal Schwannomas: Analysis of 169 Patients From a Multicenter International Database.

Responsiveness, Sensitivity, and Minimally Detectable Difference of the Graded and Redefined Assessment of Strength, Sensibility, and Prehension, Version 1.0.

Survival and Clinical Outcomes in Surgically Treated Patients With Metastatic Epidural Spinal Cord Compression: Results of the Prospective Multicenter AOSpine Study.

Clinical and Surgical Predictors of Complications Following Surgery for the Treatment of Cervical Spondylotic Myelopathy: Results From the Multicenter, Prospective AOSpine International Study of 479 Patients.

Assessment of Impact of Long-Cassette Standing X-Rays on Surgical Planning for Cervical Pathology: An International Survey of Spine Surgeons.

Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy.

Defining the Pathway to Definitive Care and Surgical Decompression after Traumatic Spinal Cord Injury: Results of a Canadian Population-Based Cohort Study.

A Clinical Prediction Rule for Functional Outcomes in Patients Undergoing Surgery for Degenerative Cervical Myelopathy: Analysis of an International Prospective Multicenter Data Set of 757 Subjects.

Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group.

The Practical Application of Clinical Prediction Rules: A Commentary Using Case Examples in Surgical Patients with Degenerative Cervical Myelopathy.

Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor database.

Patterns of epidural progression following postoperative spine stereotactic body radiotherapy: implications for clinical target volume delineation.

Early Versus Delayed Surgical Decompression of Spinal Cord after Traumatic Cervical Spinal Cord Injury: A Cost-Utility Analysis.

Meaning of self-management from the perspective of individuals with traumatic spinal cord injury, their caregivers, and acute care and rehabilitation managers: an opportunity for improved care delivery.

Changes in Pain Processing in the Spinal Cord and Brainstem after Spinal Cord Injury Characterized by Functional Magnetic Resonance Imaging.

Efficacy of i-Factor™ Bone Graft versus Autograft in Anterior Cervical Discectomy and Fusion: Results of the Prospective Randomized Single-blinded Food and Drug Administration Investigational Device Exemption Study.

Surgical Management of Spinal Chondrosarcomas.

Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI.

Neurologic Outcomes of Complex Adult Spinal Deformity Surgery: Results of the Prospective, Multicenter Scoli-RISK-1 Study.

Rapid improvements in pain and quality of life are sustained after surgery for spinal metastases in a large prospective cohort.

Chronic hypertrophic nonunion of the Type II odontoid fracture causing cervical myelopathy: Case report and review of literature.

Comparison of Outcomes of Surgical Treatment for Ossification of the Posterior Longitudinal Ligament Versus Other Forms of Degenerative Cervical Myelopathy: Results from the Prospective, Multicenter AOSpine CSM-International Study of 479 Patients.

Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study.

Development of a Competence-Based Spine Surgery Fellowship Curriculum Set of Learning Objectives in Canada.

Do Caucasians and East Asians have Different Outcomes Following Surgery for the Treatment of Degenerative Cervical Myelopathy? Results from the Prospective Multicenter AOSpine International Study.

Survival and clinical outcomes in patients with metastatic epidural spinal cord compression after spinal surgery: a prospective, multicenter, observational cohort study.

The selection of core International Classification of Functioning, Disability, and Health (ICF) categories for patient-reported outcome measurement in spine trauma patients-results of an international consensus process.

Systemic and Topical Use of Tranexamic Acid in Spinal Surgery: A Systematic Review.

Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury.

Rodent Hypoxia-Ischemia Models for Cerebral Palsy Research: A Systematic Review.

Association Between Paraspinal Muscle Morphology, Clinical Symptoms and Functional Status in Patients With Degenerative Cervical Myelopathy.

Early Intravenous Delivery of Human Brain Stromal Cells Modulates Systemic Inflammation and Leads to Vasoprotection in Traumatic Spinal Cord Injury.

Introduction: Degenerative cervical myelopathy: diagnostic, assessment, and management strategies, surgical complications, and outcome prediction.

Predicting the minimum clinically important difference in patients undergoing surgery for the treatment of degenerative cervical myelopathy.

Magnetic resonance imaging assessment of degenerative cervical myelopathy: a review of structural changes and measurement techniques.

Degenerative cervical myelopathy.

The value of CT and MRI in the classification and surgical decision-making among spine surgeons in thoracolumbar spinal injuries.

How best to manage the Spinal Epidural Abscess? A Current Systematic Review.

Self-assembling peptides optimize the post-traumatic milieu and synergistically enhance the effects of neural stem cell therapy after cervical spinal cord injury.

Recent advances in managing a spinal cord injury secondary to trauma.

Surgical Management of the Elderly With Traumatic Cervical Spinal Cord Injury: A Cost-Utility Analysis.

The modified Japanese Orthopaedic Association scale: establishing criteria for mild, moderate and severe impairment in patients with degenerative cervical myelopathy.

Modulating the immune response in spinal cord injury.

The Impact of Depression and Bipolar Disorders on Functional and Quality of Life Outcomes in Patients Undergoing Surgery for Degenerative Cervical Myelopathy: Analysis of a Combined Prospective Dataset.

162 Tobacco Smoking and Outcomes of Surgical Decompression in Patients With Symptomatic Degenerative Cervical Spondylotic Myelopathy.

163 Microstructural MRI Quantifies Tract-Specific Injury and Correlates With Global Disability and Focal Neurological Deficits in Degenerative Cervical Myelopathy.

179 Chemogenetic Stimulation of the Lumbar Locomotor Network Enhances Motor Function Following Experimental Cervical Spinal Cord Injury: Translational Relevance for a Novel Therapeutic Strategy.

181 Guidelines for the Management of Patients With Spinal Cord Injury: The Optimal Timing of Decompression.

312 Risk Factors and Clinical Outcomes of Dysphagia After Anterior Cervical Surgery in Patients With Degenerative Cervical Myelopathy: Results From the AOSpine International and North America Studies.

316 Magnetic Resonance Imaging Analysis of the Combined AOSpine North America and International Studies, Part I: The Prevalence and Spectrum of Pathologies in a Global Cohort of Patients With Degenerative Cervical Myelopathy.

329 Efficacy and Safety of Riluzole in Acute Spinal Cord Injury: Rationale and Design of AOSpine Phase III Multicenter Double-Blinded Randomized Controlled Trial (RISCIS).

366 Predictive Factors for Survival in Surgical Series of Symptomatic Metastatic Epidural Spinal Cord Compression: A Prospective North American Multicenter Study in 142 Patients.

Characteristics of Patients Who Survived < 3 Months or > 2 Years After Surgery for Spinal Metastases: Can We Avoid Inappropriate Patient Selection?

Key Preoperative Clinical Factors Predicting Outcome in Surgically Treated Patients with Metastatic Epidural Spinal Cord Compression: Results from a Survey of 438 AOSpine International Members.

A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer.

Mucosal Inducible NO Synthase-Producing IgA+ Plasma Cells in Helicobacter pylori-Infected Patients.

Clinical and pathological outcomes after resection of intramedullary spinal cord tumors: a single-institution case series.

Reported Outcome Measures in Degenerative Cervical Myelopathy: A Systematic Review.

Stereotactic Body Radiotherapy for Spinal Metastases: What are the Risks and how do we Minimize Them?

Predicting Neurologic Recovery after Surgery in Patients with Deficits Secondary to MESCC: Systematic Review.

Changing the adverse event profile in metastatic spine surgery: An evidence based approach to target wound complications and instrumentation failure.

Degenerative cervical myelopathy.

Psychometric properties of the 30-meter walking test in patients with degenerative cervical myelopathy: results from two prospective multicenter cohort studies.

Laminectomy and fusion versus laminoplasty for the treatment of degenerative cervical myelopathy: results from the aospine north america and international prospective multicenter studies.

The Relationship Between Preoperative Clinical Presentation and Quantitative Magnetic Resonance Imaging Features in Patients With Degenerative Cervical Myelopathy.