Craig A. Simmons

Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway.

Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro.

Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells.

Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity.

Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells.

A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations.

Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves.

Methylglyoxal inhibits the binding step of collagen phagocytosis.

Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels.

Substrate architecture and fluid-induced shear stress during chondrocyte seeding: role of alpha5beta1 integrin.

Mechanobiology of the aortic heart valve.

Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels.

Techniques for isolating and purifying porcine aortic valve endothelial cells.

Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential.

Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix.

Aortic valve mechanics: an emerging role for the endothelium.

Integrating polyurethane culture substrates into poly(dimethylsiloxane) microdevices.

Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration.

Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone.

A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays.

Molecular markers of early orthodontic tooth movement.

Influence of substrate stiffness on the phenotype of heart cells.

Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions.

Effects of scleral stiffness properties on optic nerve head biomechanics.

Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection.

Macro- and microscale fluid flow systems for endothelial cell biology.

Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation.

A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions.

Biaxial mechanical testing of human sclera.

Methylglyoxal-modified collagen promotes myofibroblast differentiation.

A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity.

Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro.

Single cell deposition and patterning with a robotic system.

Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration.

β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells.

Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine.

The aortic valve microenvironment and its role in calcific aortic valve disease.

Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro.

Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold.

A microfluidic membrane device to mimic critical components of the vascular microenvironment.

Inhibition of pathological differentiation of valvular interstitial cells by C-type natriuretic peptide.

Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues.

Animal models of calcific aortic valve disease.

(Micro)managing the mechanical microenvironment.

Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression.

Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain.

A digital microfluidic platform for primary cell culture and analysis.

The elastic properties of valve interstitial cells undergoing pathological differentiation.