Jorge Busciglio

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.

Fast axonal transport misregulation and Alzheimer's disease.

Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.

GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons.

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.

Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002.

Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein.

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

Beta-amyloid, oxidative stress and down syndrome.

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

Tau isoform expression and regulation in human cortical neurons.

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome.

Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?