Center for Brain Injury & Repair,
Department of Neurosurgery,
Perelman School of Medicine,
Neuroscience Graduate Group,
Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine,
Neuroscience Graduate Group, Perelman School of Medicine
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High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model.
Journal of biomechanics May, 2005 | Pubmed ID: 15797591
Neuronal response to high rate shear deformation depends on heterogeneity of the local strain field.
Journal of neurotrauma Sep, 2006 | Pubmed ID: 16958583
Collagen-dependent neurite outgrowth and response to dynamic deformation in three-dimensional neuronal cultures.
Annals of biomedical engineering May, 2007 | Pubmed ID: 17385044
Microfluidic engineered high cell density three-dimensional neural cultures.
Journal of neural engineering Jun, 2007 | Pubmed ID: 17409489
Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal-astrocytic co-cultures.
Brain research Jul, 2007 | Pubmed ID: 17555726
In vitro neural injury model for optimization of tissue-engineered constructs.
Journal of neuroscience research Dec, 2007 | Pubmed ID: 17671988
High cell density three-dimensional neural co-cultures require continuous medium perfusion for survival.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference , 2006 | Pubmed ID: 17946846
High rate shear insult delivered to cortical neurons produces heterogeneous membrane permeability alterations.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference , 2006 | Pubmed ID: 17946956
SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications.
Journal of biomedical materials research. Part A Apr, 2009 | Pubmed ID: 18431778
Three-dimensional neural constructs: a novel platform for neurophysiological investigation.
Journal of neural engineering Sep, 2008 | Pubmed ID: 18756031
Developing a tissue-engineered neural-electrical relay using encapsulated neuronal constructs on conducting polymer fibers.
Journal of neural engineering Dec, 2008 | Pubmed ID: 18827311
A novel neuroprosthetic interface with the peripheral nervous system using artificially engineered axonal tracts.
Neurological research Dec, 2008 | Pubmed ID: 19079981
Long-term survival and integration of transplanted engineered nervous tissue constructs promotes peripheral nerve regeneration.
Tissue engineering. Part A Jul, 2009 | Pubmed ID: 19231968
A microperfused incubator for tissue mimetic 3D cultures.
Biomedical microdevices Dec, 2009 | Pubmed ID: 19562488
Synapse-to-neuron ratio is inversely related to neuronal density in mature neuronal cultures.
Brain research Nov, 2010 | Pubmed ID: 20800585
Color changing photonic crystals detect blast exposure.
NeuroImage Jan, 2011 | Pubmed ID: 21040795
State of the art and future challenges in neural engineering: neural interfaces: foreword / editors' commentary (volume 1).
Critical reviews in biomedical engineering , 2011 | Pubmed ID: 21488811
State of the art and future challenges in neural engineering: strategies for nervous system repair foreword / editors' commentary (volume 2).
Critical reviews in biomedical engineering , 2011 | Pubmed ID: 21488816
Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges.
Critical reviews in biomedical engineering , 2011 | Pubmed ID: 21488817
Effects of freezing profile parameters on the survival of cryopreserved rat embryonic neural cells.
Journal of neuroscience methods Sep, 2011 | Pubmed ID: 21816171
Transformative research in neural engineering: Foreword / editors' commentary (volume 3).
Critical reviews in biomedical engineering , 2011 | Pubmed ID: 21967301
Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (Part 1).
Critical reviews in biomedical engineering , 2011 | Pubmed ID: 21967303
Neural tissue engineering for neuroregeneration and biohybridized interface microsystems in vivo (Part 2).
Critical reviews in biomedical engineering , 2011 | Pubmed ID: 21967304
Trauma-induced plasmalemma disruptions in three-dimensional neural cultures are dependent on strain modality and rate.
Journal of neurotrauma Nov, 2011 | Pubmed ID: 22023556
Blast-induced color change in photonic crystals corresponds with brain pathology.
Journal of neurotrauma Nov, 2011 | Pubmed ID: 22082449
Microtissue engineered constructs with living axons for targeted nervous system reconstruction.
Tissue engineering. Part A Nov, 2012 | Pubmed ID: 22702955
Bionic connections.
Scientific American Jan, 2013 | Pubmed ID: 23342452
Animal models of traumatic brain injury.
Handbook of clinical neurology , 2015 | Pubmed ID: 25702213
Restoring nervous system structure and function using tissue engineered living scaffolds.
Neural regeneration research May, 2015 | Pubmed ID: 26109930
A three-dimensional image processing program for accurate, rapid, and semi-automated segmentation of neuronal somata with dense neurite outgrowth.
Frontiers in neuroanatomy , 2015 | Pubmed ID: 26257609
Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks.
Tissue engineering. Part A Nov, 2015 | Pubmed ID: 26414439
SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury.
Acta neuropathologica Jan, 2016 | Pubmed ID: 26589592
Neural Substrate Expansion for the Restoration of Brain Function.
Frontiers in systems neuroscience , 2016 | Pubmed ID: 26834579
Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration.
Acta biomaterialia Jul, 2016 | Pubmed ID: 27090594
Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration.
Journal of tissue engineering and regenerative medicine Jun, 2016 | Pubmed ID: 27273796
A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27604725
The Evolution of Neuroprosthetic Interfaces.
Critical reviews in biomedical engineering , 2016 | Pubmed ID: 27652455
Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine.
Experimental neurology Apr, 2017 | Pubmed ID: 28081963
Concussion Induces Hippocampal Circuitry Disruption in Swine.
Journal of neurotrauma May, 2017 | Pubmed ID: 28298170
Living scaffolds for neuroregeneration.
Current opinion in solid state & materials science Dec, 2014 | Pubmed ID: 28736499
Laura A. Struzyna*,1,2,3,
Dayo O. Adewole*,1,2,3,
Wisberty J. Gordián-Vélez1,2,3,
Michael R. Grovola2,3,
Justin C. Burrell2,3,
Kritika S. Katiyar2,3,4,
Dmitriy Petrov2,3,
James P. Harris2,3,
D. Kacy Cullen2,3
1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania,
2Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania,
3Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center,
4School of Biomedical Engineering, Drexel University
Kritika S. Katiyar*,1,2,3,
Carla C. Winter*,1,2,4,
Wisberty J. Gordián-Vélez1,2,4,
John C. O'Donnell1,2,
Yeri J. Song1,5,
Nicole S. Hernandez1,5,
Laura A. Struzyna1,2,4,
D. Kacy Cullen1,2,5
1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania,
2Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center,
3School of Biomedical Engineering, Drexel University,
4Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania,
5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania
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