Linda Partridge

A mortality cost of virginity at older ages in female Mediterranean fruit flies.

Dietary restriction in long-lived dwarf flies.

Mechanisms of ageing: public or private?

Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster.

The evolution of longevity.

A lethal side-effect.

Different cell size and cell number contribution in two newly established and one ancient body size cline of Drosophila subobscura.

Rapid laboratory evolution of adult wing area in Drosophila melanogaster in response to humidity.

Life history response of Mediterranean fruit flies to dietary restriction.

Interpreting interactions between treatments that slow aging.

The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference.

Demography of dietary restriction and death in Drosophila.

Superoxide and hydrogen peroxide production by Drosophila mitochondria.

Testing for asymmetrical gene flow in a Drosophila melanogaster body-size cline.

QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of Drosophila melanogaster on different continents.

Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster.

Long-lived Drosophila with overexpressed dFOXO in adult fat body.

Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity.

Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila.

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster.

The interaction between FOXO and SIRT1: tipping the balance towards survival.

Computational analysis of alpha-helical membrane protein structure: implications for the prediction of 3D structural models.

Genetic variation for total fitness in Drosophila melanogaster: complex yet replicable patterns.

Dietary restriction, mortality trajectories, risk and damage.

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.

Sex and death: what is the connection?

Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary.

Dietary restriction in Drosophila.

Counting the calories: the role of specific nutrients in extension of life span by food restriction.

Calories do not explain extension of life span by dietary restriction in Drosophila.

Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster.

Diet, metabolism and lifespan in Drosophila.

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

Genome-wide gene expression in response to parasitoid attack in Drosophila.

Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation.

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster.

The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila.

Flight activity, mortality rates, and lipoxidative damage in Drosophila.

No extension of lifespan by ablation of germ line in Drosophila.

Beyond the evolutionary theory of ageing, from functional genomics to evo-gero.

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.

Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution.

A functioning ovary is not required for sex peptide to reduce receptivity to mating in D. melanogaster.

Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction"Exp. Gerontology, doi:10.1016/j.exger.2006.10.009.

Role of insulin-like signalling in Drosophila lifespan.

Dietary restriction in Drosophila: delayed aging or experimental artefact?

Dynamics of the action of dFOXO on adult mortality in Drosophila.

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.

Correcting for sequence biases in present/absent calls.

Estimation and correction of non-specific binding in a large-scale spike-in experiment.

Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster.

Evolutionary conservation of regulated longevity assurance mechanisms.

Some highlights of research on aging with invertebrates, 2006-2007.

Antagonizing Methuselah to extend life span.

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.

Brief carbon dioxide exposure blocks heat hardening but not cold acclimation in Drosophila melanogaster.

Optimization of dietary restriction protocols in Drosophila.

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

Benchmarks for ageing studies.

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response.

Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster.

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

Toward a control theory analysis of aging.

Feeding, fecundity and lifespan in female Drosophila melanogaster.

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".

New model of health promotion and disease prevention for the 21st century.

Stage debut for the elusive Drosophila insulin-like growth factor binding protein.

Some highlights of research on aging with invertebrates, 2008.

Endocrine regulation of aging and reproduction in Drosophila.

Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.

Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster.

Insulin/IGF-like signalling, the central nervous system and aging.

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan.

Longevity of Indy mutant Drosophila not attributable to Indy mutation.

Quantification of food intake in Drosophila.

Some highlights of research on aging with invertebrates, 2009.

Invertebrate models of age-related muscle degeneration.

Chemical changes in aging Drosophila melanogaster.

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila.

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.

The new biology of ageing.

A Drosophila insulin-like peptide promotes growth during nonfeeding states.

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition.

Molecular evolution and functional characterization of Drosophila insulin-like peptides.

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.

Biomarkers of aging in Drosophila.

Extending healthy life span--from yeast to humans.

Insulin signalling regulates remating in female Drosophila.

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network.

Some highlights of research on aging with invertebrates, 2010.

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.

The new science of ageing.

Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.

Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence analyses of the Dca gene.

A longer and healthier life with TOR down-regulation: genetics and drugs.

dFOXO-independent effects of reduced insulin-like signaling in Drosophila.

Unraveling the biological roles of reactive oxygen species.

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.

Dietary restriction and aging: a unifying perspective.

Death and dessert: nutrient signalling pathways and ageing.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.

Current developments at Philosophical Transactions of the Royal Society B.

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice.