Constantin Radu

Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines.

Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines.

A profiling platform for the identification of selective metalloprotease inhibitors.

A high density assay format for the detection of novel cytotoxic agents in large chemical libraries.

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.

Development and validation of a high-density fluorescence polarization-based assay for the trypanosoma RNA triphosphatase TbCet1.

A miniaturized 1536-well format gamma-secretase assay.

Live-cell imaging of caspase activation for high-content screening.

High-content assay to identify inhibitors of dengue virus infection.

Comparison of luminescence ADP production assay and radiometric scintillation proximity assay for Cdc7 kinase.

A high throughput scintillation proximity imaging assay for protein methyltransferases.

An image-based biosensor assay strategy to screen for modulators of the microRNA 21 biogenesis pathway.

Designs and concept reliance of a fully automated high-content screening platform.

An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway.

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.

An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidates.

A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay.

Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.

A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells.

Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling.

Chemical & RNAi screening at MSKCC: a collaborative platform to discover & repurpose drugs to fight disease.

A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.

Small-molecule inhibitors of SETD8 with cellular activity.

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.

High-Content Screening of Raw Actinomycete Extracts for the Identification of Antituberculosis Activities.

Evaluation of Compound Optical Interference in High-Content Screening.