Morgan Huse

Shouts, whispers and the kiss of death: directional secretion in T cells.

The T-cell-receptor signaling network.

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells.

Photochemical approaches to T-cell activation.

Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

Lymphocyte polarity, the immunological synapse and the scope of biological analogy.

Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond.

Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells.

Novel Foxo1-dependent transcriptional programs control T(reg) cell function.

Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells.

NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand.

IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II.

From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells.

Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.

Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells.

CD28 and CD3 have complementary roles in T-cell traction forces.

The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse.

Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse.

Lipid-based patterning of the immunological synapse.

Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody.

A Generalizable Platform for the Photoactivation of Cell Surface Receptors.

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.

Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors.

Mechanical Communication at the Immunological Synapse.

Probing Synaptic Biomechanics Using Micropillar Arrays.

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.

Mechanical forces in the immune system.