Richard Losick

Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis.

Genetic analysis of Bacillus subtilis spo mutations generated by Tn917-mediated insertional mutagenesis.

Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation.

Appearance of a ribonucleic acid polymerase-binding protein in asporogenous mutants of Bacillus subtilis.

An immunological assay for the sigma subunit of RNA polymerase in extracts of vegetative and sporulating Bacillus subtilis.

Chloramphenicol restores sigma factor activity to sporulating Bacillus subtilis.

In vitro synthesis of ribosomal RNA by Bacillus subtilis RNA polymerase.

Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis.

Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites.

Purification of an extracellular signaling molecule involved in production of aerial mycelium by Streptomyces coelicolor.

Negative regulation of the proteolytic activation of a developmental transcription factor in Bacillus subtilis.

Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants.

Propagation by sporulation in the guinea pig symbiont Metabacterium polyspora.

Subcellular localization of Bacillus subtilis SMC, a protein involved in chromosome condensation and segregation.

A four-dimensional view of assembly of a morphogenetic protein during sporulation in Bacillus subtilis.

Septation, dephosphorylation, and the activation of sigmaF during sporulation in Bacillus subtilis.

Changing views on the nature of the bacterial cell: from biochemistry to cytology.

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors.

The transcriptional profile of early to middle sporulation in Bacillus subtilis.

Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation.

Coupling of asymmetric division to polar placement of replication origin regions in Bacillus subtilis.

Cytological evidence for association of the ends of the linear chromosome in Streptomyces coelicolor.

Molecular biology. Turning gene regulation on its head.

RNA polymerase sigma factor that blocks morphological differentiation by Streptomyces coelicolor.

Fruiting body formation by Bacillus subtilis.

An investigation into the compartmentalization of the sporulation transcription factor sigmaE in Bacillus subtilis.

A sporulation membrane protein tethers the pro-sigmaK processing enzyme to its inhibitor and dictates its subcellular localization.

Cell biology. Fats, flies, and palmitate.

Asymmetric cell division in B. subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ.

Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture.

FtsA mutants of Bacillus subtilis impaired in sporulation.

Genome-wide analysis of the stationary-phase sigma factor (sigma-H) regulon of Bacillus subtilis.

A widely conserved bacterial cell division protein that promotes assembly of the tubulin-like protein FtsZ.

Does RNA polymerase help drive chromosome segregation in bacteria?

RacA, a bacterial protein that anchors chromosomes to the cell poles.

Subcellular localization of a small sporulation protein in Bacillus subtilis.

Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis.

The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.

Evidence in support of a docking model for the release of the transcription factor sigma F from the antisigma factor SpoIIAB in Bacillus subtilis.

The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division.

Cannibalism by sporulating bacteria.

Swarming motility in undomesticated Bacillus subtilis.

Unique degradation signal for ClpCP in Bacillus subtilis.

A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis.

The Spo0A regulon of Bacillus subtilis.

Assembly of the SpoIIIE DNA translocase depends on chromosome trapping in Bacillus subtilis.

A threshold mechanism governing activation of the developmental regulatory protein sigma F in Bacillus subtilis.

Genes governing swarming in Bacillus subtilis and evidence for a phase variation mechanism controlling surface motility.

Novel genes that influence development in Streptomyces coelicolor.

Genes involved in formation of structured multicellular communities by Bacillus subtilis.

Insulation of the sigmaF regulatory system in Bacillus subtilis.

Dynamic patterns of subcellular protein localization during spore coat morphogenesis in Bacillus subtilis.

The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.

Unmasking novel sporulation genes in Bacillus subtilis.

A master regulator for biofilm formation by Bacillus subtilis.

High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis.

Protein localization: reach out and touch the forespore.

Defining a centromere-like element in Bacillus subtilis by Identifying the binding sites for the chromosome-anchoring protein RacA.

Genetic dissection of the sporulation protein SpoIIE and its role in asymmetric division in Bacillus subtilis.

Developmental commitment in a bacterium.

Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A.

Small untranslated RNA antitoxin in Bacillus subtilis.

Cell population heterogeneity during growth of Bacillus subtilis.

Genes for small, noncoding RNAs under sporulation control in Bacillus subtilis.

Targets of the master regulator of biofilm formation in Bacillus subtilis.

A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.

The forespore line of gene expression in Bacillus subtilis.

Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis.

Bacillus subtilis genome diversity.

Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins.

Peptide anchoring spore coat assembly to the outer forespore membrane in Bacillus subtilis.

gerT, a newly discovered germination gene under the control of the sporulation transcription factor sigmaK in Bacillus subtilis.

Thinking about Bacillus subtilis as a multicellular organism.

Bistability and biofilm formation in Bacillus subtilis.

Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.

Control of cell fate by the formation of an architecturally complex bacterial community.

Stochasticity and cell fate.

A novel regulatory protein governing biofilm formation in Bacillus subtilis.

Ecology and genomics of Bacillus subtilis.

A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels.

Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores.

Polar localization and compartmentalization of ClpP proteases during growth and sporulation in Bacillus subtilis.

ATP-driven self-assembly of a morphogenetic protein in Bacillus subtilis.

Grasping at origins.

Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis.

Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis.

A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation.

Geometric cue for protein localization in a bacterium.

The conserved sporulation protein YneE inhibits DNA replication in Bacillus subtilis.

A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis.

Paracrine signaling in a bacterium.

Negative membrane curvature as a cue for subcellular localization of a bacterial protein.

Cannibalism enhances biofilm development in Bacillus subtilis.

Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis.

Amyloid fibers provide structural integrity to Bacillus subtilis biofilms.

Do mycobacteria produce endospores?

An epigenetic switch governing daughter cell separation in Bacillus subtilis.

Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis.

D-amino acids trigger biofilm disassembly.

Protein subcellular localization in bacteria.

KinD is a checkpoint protein linking spore formation to extracellular-matrix production in Bacillus subtilis biofilms.

Small genes under sporulation control in the Bacillus subtilis genome.

Reversal of an epigenetic switch governing cell chaining in Bacillus subtilis by protein instability.

The biocide chlorine dioxide stimulates biofilm formation in Bacillus subtilis by activation of the histidine kinase KinC.

A small protein required for the switch from {sigma}F to {sigma}G during sporulation in Bacillus subtilis.

Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilis.

The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acids.

Tracing the domestication of a biofilm-forming bacterium.

An accessory protein required for anchoring and assembly of amyloid fibres in B. subtilis biofilms.

Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis.

Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development.

Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms.

Interspecies interactions that result in Bacillus subtilis forming biofilms are mediated mainly by members of its own genus.

Whole-genome sequences of Bacillus subtilis and close relatives.

A self-produced trigger for biofilm disassembly that targets exopolysaccharide.

A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants.

Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis.

Osmotic pressure can regulate matrix gene expression in Bacillus subtilis.

Galactose metabolism plays a crucial role in biofilm formation by Bacillus subtilis.

Biocontrol of tomato wilt disease by Bacillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation.

Gene conservation among endospore-forming bacteria reveals additional sporulation genes in Bacillus subtilis.

Liquid transport facilitated by channels in Bacillus subtilis biofilms.

Sticking together: building a biofilm the Bacillus subtilis way.

Synthesis and activity of biomimetic biofilm disruptors.

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis.

Bacillus subtilis biofilm induction by plant polysaccharides.

Respiration control of multicellularity in Bacillus subtilis by a complex of the cytochrome chain with a membrane-embedded histidine kinase.

Isolation, characterization, and aggregation of a structured bacterial matrix precursor.

A novel RNA polymerase-binding protein controlling genes involved in spore germination in Bacillus subtilis.

A conserved ClpP-like protease involved in spore outgrowth in Bacillus subtilis.

D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis.

Memory and modularity in cell-fate decision making.

A serine sensor for multicellularity in a bacterium.

Functional analysis of the accessory protein TapA in Bacillus subtilis amyloid fiber assembly.

A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA.

Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis.

Self-regulation of exopolysaccharide production in Bacillus subtilis by a tyrosine kinase.

The extracellular matrix of Staphylococcus aureus biofilms comprises cytoplasmic proteins that associate with the cell surface in response to decreasing pH.

A love affair with Bacillus subtilis.

Identification and characterization of mutations conferring resistance to D-amino acids in Bacillus subtilis.

Alternative modes of biofilm formation by plant-associated Bacillus cereus.

Stochastic Switching of Cell Fate in Microbes.

An Electrostatic Net Model for the Role of Extracellular DNA in Biofilm Formation by Staphylococcus aureus.

Biofilm formation by Bacillus subtilis requires an endoribonuclease-containing multisubunit complex that controls mRNA levels for the matrix gene repressor SinR.

Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase.

Colony-morphology screening uncovers a role for the Pseudomonas aeruginosa nitrogen-related phosphotransferase system in biofilm formation.

Bacterial backstabbing: EF-Tu, brute?

An Amino Acid Substitution in RNA Polymerase That Inhibits the Utilization of an Alternative Sigma Factor.

A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.

A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site.

Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus.

Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis.

Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans.

Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis.

Reconstitution of Staphylococcus aureus Lipoteichoic Acid Synthase Activity Identifies Congo Red as a Selective Inhibitor.