Todd McDevitt’s research focuses on engineering technologies that direct the differentiation and morphogenesis of stem cells into functional tissue constructs. The lab is working to create human tissue models that can be used to study development and new approaches to treat multiple diseases that afflict the cardiovascular, neurological, immunological, and musculoskeletal systems.
We are studying stem cell differentiation and morphogenesis to engineer three-dimensional, multicellular systems that can be used to study principles of stem cell and developmental biology. We are designing many new technologies to better control and assess stem cell phenotypes, with a particular focus on scalable methods and non-destructive analyses that are directly and immediately relevant to biomanufacturing needs. We are creating novel biotherapeutic approaches based on factors derived from stem cells to facilitate regenerative molecular therapies and engineer new platforms that can model and treat a variety of biomedical problems, including cardiovascular disease, neurological and immunological disorders, and traumatic musculoskeletal injuries.
He has received several honors and awards for research, mentoring and teaching which include: New Investigator Award from the American Heart Association and the Society for Biomaterials Young Investigator Award and was inducted in the American Institute of Medical and Biological Engineering College of Fellows and most recently, was awarded the California Institute of Regenerative Medicine (CIRM) Research Leadership Award, which enabled his move to the Gladstone Institutes in San Francisco in 2015.
Visit: http://mcdevitt.gladstone.org/people/profiles?who=Todd-McDevitt
Differentiation of V2a interneurons from human pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America 05, 2017 | Pubmed ID: 28438991
Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.
Nature communications 10, 2018 | Pubmed ID: 30291250
Author Correction: Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment.
Nature communications 11, 2018 | Pubmed ID: 30446658
Ana C. Silva1,2,3,4,
Maria J. Oliveira1,2,5,
Todd C McDevitt4,6,
Mário A. Barbosa1,2,3,
Diana S. Nascimento1,2,
Perpétua Pinto-do-Ó1,2,3
1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto,
2INEB - Instituto de Engenharia Biomédica, Universidade do Porto,
3Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto,
4, Gladstone Institute of Cardiovascular Disease,
5Faculty of Medicine, University of Porto,
6, University of California San Francisco
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