Phillip D. Zamore

Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.

Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies.

MicroRNAs: regulating a change of heart.

RNAi: nature abhors a double-strand.

Why do miRNAs live in the miRNP?

Ancient pathways programmed by small RNAs.

A microRNA in a multiple-turnover RNAi enzyme complex.

Modular recognition of RNA by a human pumilio-homology domain.

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

A biochemical framework for RNA silencing in plants.

siRNAs knock down hepatitis.

In vitro analysis of RNA interference in Drosophila melanogaster.

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.

Asymmetry in the assembly of the RNAi enzyme complex.

Biochemical dissection of RNA silencing in plants.

Sequence-specific inhibition of small RNA function.

Plant RNAi: How a viral silencing suppressor inactivates siRNA.

RISC assembly defects in the Drosophila RNAi mutant armitage.

The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

Kinetic analysis of the RNAi enzyme complex.

MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region.

A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe.

A protein sensor for siRNA asymmetry.

MicroRNA biogenesis: drosha can't cut it without a partner.

Perspective: machines for RNAi.

Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.

Ribo-gnome: the big world of small RNAs.

microPrimer: the biogenesis and function of microRNA.

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.

Rethinking the microprocessor.

A distinct small RNA pathway silences selfish genetic elements in the germline.

Designing siRNA that distinguish between genes that differ by a single nucleotide.

RNA interference: big applause for silencing in Stockholm.

RNA silencing: genomic defence with a slice of pi.

The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.

Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.

Sorting of Drosophila small silencing RNAs.

Beginning to understand microRNA function.

Small silencing RNAs.

Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies.

Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells.

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells.

Linking SNPs to CAG repeat length in Huntington's disease patients.

Small silencing RNAs: an expanding universe.

Nucleus and gene expression.

A role for microRNAs in the Drosophila circadian clock.

The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.

Huntington's disease: silencing a brutal killer.

SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle.

SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle.

Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway.

Welcome to silence.

Target RNA-directed trimming and tailing of small silencing RNAs.

Somatic piRNA biogenesis.

Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins.

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression.

Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.

Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.

A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation.

Argonaute proteins.

Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.

The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1.

Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains.

Adaptation to P element transposon invasion in Drosophila melanogaster.

Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles.