Kazuhisa Takahashi

[Clinical evaluation of meningeal carcinomatosis associated with primary lung cancer].

Serum tenascin-C as a potential predictive marker of angiogenesis in non-small cell lung cancer.

Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity.

[An elderly case of sarcoidosis with multiple pulmonary cysts].

Multilocular thymic cyst associated with follicular hyperplasia: clinicopathologic study of 4 resected cases.

[A case of non-small cell lung cancer accompanied with hemorrhage after chemotherapy including gemcitabine].

Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking.

Pulmonary sarcoidosis and antiphospholipid syndrome.

Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients.

[Case of Heerfordt's syndrome with prolonged peripheral nerve involvement].

Prognostic factors in patients with inoperable non-small cell lung cancer--an analysis of long-term survival patients.

Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell.

Signal transduction mediated by endostatin directly modulates cellular function of lung cancer cells in vitro.

Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice.

Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and recurrent pneumothorax.

Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyomatosis cell clusters found in chylous pleural effusion.

[A case of pulmonary arteriovenous fistula associated with multiple hepatic arterioportal shunts].

Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain.

[A case of exogenous lipoid pneumonia with marked elevation of serum KL-6 and interstitial lung shadows due to aspiration of liquid paraffin].

Peritoneovenous shunting for intractable chylous ascites complicated with lymphangioleiomyomatosis.

Successful resection of dermatomyositis associated with thymic carcinoma: report of a case.

Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma.

Vinorelbine is effective for the malignant pleural effusion associated with lung cancer in mice.

Isolated congenital spleen agenesis: a rare cause of chronic thromboembolic pulmonary hypertension in an adult.

Osteopontin is involved in the formation of malignant pleural effusion in lung cancer.

B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma.

[Evaluation of clinical effectiveness of Pazufloxacin Mesilate in acute exacerbation of chronic respiratory diseases].

[Efficacy of gefitinib according to smoking status in non-small cell lung cancer patients].

ERC/mesothelin as a marker for chemotherapeutic response in patients with mesothelioma.

Osteopontin is involved in the development of acquired chemo-resistance of cisplatin in small cell lung cancer.

Malignant pleurisy associated with primary lung cancer well controlled by pleurodesis using distilled water.

An autopsy case of subacute cor pulmonale due to pulmonary tumor cell emboli in a patient with gastric cancer.

Refractory recurrent thymoma successfully treated with long-acting somatostatin analogue and prednisolone.

Osteopontin modulates malignant pleural mesothelioma cell functions in vitro.

Cytologic, immunocytochemical and ultrastructural characterization of lymphangioleiomyomatosis cell clusters in chylous effusions of patients with lymphangioleiomyomatosis.

Characteristics of pulmonary cysts in Birt-Hogg-Dubé syndrome: thin-section CT findings of the chest in 12 patients.

Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma.

[A case of pulmonary metastases from bladder cancer, suspected of recurrent Wegener's granulomatosis].

[Two cases of familial summer-type hypersensitivity pneumonitis requiring differentiation from bird breeder's lung].

Distinct roles of cholinergic receptors in small cell lung cancer cells.

A pleuro-peritoneal communication through the diaphragm affected with lymphangioleiomyomatosis.

Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.

[Twelve cases of advanced thymic carcinoma: a clinical review].

A rare image of a pulmonary nodule revealed on FDG-PET scans.

Thymic adenocarcinoma with sarcomatoid features characterized by intracaval tumor growth: report of a case.

Benign giant mediastinal schwannoma presenting as cardiac tamponade in a woman: a case report.

Breakthrough lung Scedosporium prolificans infection with multiple cavity lesions in a patient receiving voriconazole for probable invasive aspergillosis associated with monoclonal gammopathy of undetermined significance (MGUS).

Sex hormones alter Th1 responses and enhance granuloma formation in the lung.

Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin.

Differentiation between Birt-Hogg-Dubé syndrome and lymphangioleiomyomatosis: quantitative analysis of pulmonary cysts on computed tomography of the chest in 66 females.

[Recent progress for chemotherapy in advanced non-small cell lung cancer].

Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α.

Prevalence of uterine and adnexal involvement in pulmonary lymphangioleiomyomatosis: a clinicopathologic study of 10 patients.

Factors influencing weaning from mechanical ventilation in elderly patients with severe pneumonia.

A feasibility study of zoledronic acid combined with carboplatin/nedaplatin plus paclitaxel in patients with non-small cell lung cancer with bone metastases.

Year in review 2011: acute lung injury, interstitial lung diseases, physiology, sleep and lung cancer.

Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice.

Uterine angiosarcoma associated with lymphangioleiomyomatosis in a patient with tuberous sclerosis complex: an autopsy case report with immunohistochemical and genetic analysis.

Pulmonary rehabilitation program including respiratory conditioning for chronic obstructive pulmonary disease (COPD): Improved hyperinflation and expiratory flow during tidal breathing.

Malignant lymphoma with diffuse cardiac involvement detected by multiple imaging examinations: a case report.

From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers.

Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.

Lung cancer stem cells: tumor biology and clinical implications.

Quantitative CT analysis of small pulmonary vessels in lymphangioleiomyomatosis.

Bronchial reversibility with a short-acting β2-agonist predicts the FEV1 response to administration of a long-acting β2-agonist with inhaled corticosteroids in patients with bronchial asthma.

[Efficacy of erlotinib after gefitinib administration in patients with non-small cell lung cancer].

Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer.

Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia.

Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancer.

Concave pattern of a maximal expiratory flow-volume curve: a sign of airflow limitation in adult bronchial asthma.

Year in review 2012: lung cancer, respiratory infections, tuberculosis, pleural diseases, bronchoscopic intervention and imaging.

Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice.

High prevalence of gene abnormalities in young patients with lung cancer.

The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma.

Oncostatin M modulates fibroblast function via signal transducers and activators of transcription proteins-3.

Prevalence and clinical features of lymphedema in patients with lymphangioleiomyomatosis.

Molecular mechanisms contributing to resistance to tyrosine kinase-targeted therapy for non-small cell lung cancer.

Effect of glucocorticoid monotherapy on pulmonary function and survival in Japanese patients with scleroderma-related interstitial lung disease.

Chronic intermittent hypoxia/reoxygenation facilitate amyloid-β generation in mice.

Efficacy and safety of low-dose sirolimus for treatment of lymphangioleiomyomatosis.

Solitary fibrous tumor of the pleura: ultrasonographic imaging findings of 3 cases.

Effect of continuous positive airway pressure on regional cerebral blood flow during wakefulness in obstructive sleep apnea.

Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration.

Relationship between quantitative CT metrics and pulmonary function in combined pulmonary fibrosis and emphysema.

Small-cell lung cancer exhibiting spontaneous regression.

Pneumocystis pneumonia induced by treatment with low-dose tacrolimus and methylprednisolone in a patient with rheumatoid arthritis: a case report.

Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor.

A pulmonary nodule exhibiting temporary spontaneous regression.

[Illustrated review on radiological diagnosis of occupational respiratory diseases].

Acquired resistance of non-small cell lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors.

Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system.

Year in review 2013: Lung cancer, respiratory infections, tuberculosis, cystic fibrosis, pleural diseases, bronchoscopic intervention and imaging.

Cystic, nodular and cavitary metastases to the lungs in a patient with endometrial stromal sarcoma of the uterus.

Interesting radiological images of a tuberculous abscess.

What׳s the role of sirolimus on the treatment of lymphangioleiomyomatosis (LAM)?: Merely tuning up of LAM-associated dysfunctional lymphatic vessels rather than cytoreduction?

Tocilizumab, a proposed therapy for the cachexia of Interleukin6-expressing lung cancer.

Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease.

Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma.

Potential risk of TNF inhibitors on the progression of interstitial lung disease in patients with rheumatoid arthritis.

Prevalence and risk factors of aortic aneurysm in patients with chronic obstructive pulmonary disease.

Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer.

[Comparison of exhaled nitric oxide levels measured by two offline methods and the NO breath® method in Japan].

Strategies for an effective tobacco harm reduction policy in Indonesia.

Computed tomographic features of lymphangioleiomyomatosis: evaluation in 138 patients.

Year in review 2014: Lung cancer, pleural diseases, respiratory infections and tuberculosis, bronchoscopic intervention and imaging.

Chemotherapy-Regulated microRNA-125-HER2 Pathway as a Novel Therapeutic Target for Trastuzumab-Mediated Cellular Cytotoxicity in Small Cell Lung Cancer.

The impact of co-existing seasonal allergic rhinitis caused by Japanese Cedar Pollinosis (SAR-JCP) upon asthma control status.

Practical surrogate marker of pulmonary dysanapsis by simple spirometry: an observational case-control study in primary care.

TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells.

Autoimmune pulmonary alveolar proteinosis with primary lung cancer in a patient of very advanced years.

Do respiratory comorbidities limit the diagnostic usefulness of ultrasound-guided needle aspiration for subpleural lesions?

Effects of transdermal tulobuterol on dyspnea and respiratory function during exercise in patients with chronic obstructive pulmonary disease.

Surgical Intervention for Non-Small-Cell Lung Cancer Patients with Pleural Carcinomatosis: Results From the Japanese Lung Cancer Registry in 2004.

Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation.

Prognostic factors in non-small cell lung cancer patients who are recommended to receive single-agent chemotherapy (docetaxel or pemetrexed) as a second- or third-line chemotherapy: in the era of oncogenic drivers and molecular-targeted agents.

Medical Decision-Making Incapacity among Newly Diagnosed Older Patients with Hematological Malignancy Receiving First Line Chemotherapy: A Cross-Sectional Study of Patients and Physicians.

Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma.

Pleural Covering Application for Recurrent Pneumothorax in a Patient with Birt-Hogg-Dubé Syndrome.

Potential Role of CT Metrics in Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension.

A Model of Lymphangioleiomyomatosis in a Three-Dimensional Culture System.

Variation in the expression levels of predictive chemotherapy biomarkers in histological subtypes of lung adenocarcinoma: an immunohistochemical study of tissue samples.

Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease, asthma-COPD overlap syndrome and bronchial asthma.

Diagnostic significance of cerebrospinal fluid EGFR mutation analysis for leptomeningeal metastasis in non-small-cell lung cancer patients harboring an active EGFR mutation following gefitinib therapy failure.

Medical treatment involving investigational drugs and genetic profile of thymic carcinoma.

Cerebral infarction in advanced non-small cell lung cancer: a case control study.

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.

Oct4 plays a crucial role in the maintenance of gefitinib-resistant lung cancer stem cells.

Bronchial involvement in advanced stage lymphangioleiomyomatosis: histopathologic and molecular analyses.

Year in review 2015: Lung cancer, pleural diseases, respiratory infections, bronchiectasis and tuberculosis, bronchoscopic intervention and imaging.

Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis.

Bronchial-pulmonary arterial fistula with primary racemose hemangioma.

Bevacizumab-induced chronic interstitial pneumonia during maintenance therapy in non-small cell lung cancer.

Loxoprofen-induced interstitial pneumonia: a case report.

Lobe-Specific Nodal Dissection for Clinical Stage I and II NSCLC: Japanese Multi-Institutional Retrospective Study Using a Propensity Score Analysis.

A multicenter phase II trial of S-1 combined with bevacizumab after platinum-based chemotherapy in patients with advanced non-squamous non-small cell lung cancer.

Implications of Insulin-like Growth Factor 1 Receptor Activation in Lung Cancer.

Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation.

Successful treatment with weekly high-dose erlotinib against meningeal metastases from epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma.

Possible effect of abatacept on the progression of interstitial lung disease in rheumatoid arthritis patients.

Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma.

Associations between peripheral blood eosinophil counts in patients with systemic sclerosis and disease severity.

Assessing usability of the "Adherence Starts with Knowledge 20" (ASK-20) questionnaire for Japanese adults with bronchial asthma receiving inhaled corticosteroids long term.

Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients.

Autofluorescence imaging bronchoscopy as a novel approach to the management of tracheobronchopathia osteochondroplastica: a case report.

Benign clear cell "sugar" tumor of the lung in a patient with Birt-Hogg-Dubé syndrome: a case report.

Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dubé syndrome.

Development of diffuse alveolar damage after initiation of Nijutsuto.

Carcinomatous pleuritis and pericarditis accompanied by pulmonary tuberculosis.

Lung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis: a case report and literature review.

Sequential Use of Anaplastic Lymphoma Kinase Inhibitors in Japanese Patients With ALK-Rearranged Non-Small-Cell Lung Cancer: A Retrospective Analysis.

Safety of Bronchoscopy for Patients Undergoing Hemodialysis.

Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.

Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases.

Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients.

CD44 silencing decreases the expression of stem cell-related factors induced by transforming growth factor β1 and tumor necrosis factor α in lung cancer: Preliminary findings.

Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment.

Surfactant protein-D predicts prognosis of interstitial lung disease induced by anticancer agents in advanced lung cancer: a case control study.

Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165.

Pneumothorax caused by cystic and nodular lung metastases from a malignant uterine perivascular epithelioid cell tumor (PEComa).

Pulmonary Intravascular Large B-cell Lymphoma (IVLBCL) Disguised as an Asthma Exacerbation in a Patient with Asthma.

Chylothorax ascribed to chronic heart failure in a woman of very advanced years.

Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.

MicroRNAs as Therapeutic Targets in Lung Disease: Prospects and Challenges.

Meeting report: Current cancer perspectives from the 9 Annual Meeting of the Japanese Society of Medical Oncology.

Expression of thymidylate synthase predicts clinical outcomes of S-1-based chemotherapy in squamous cell lung cancer.

LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer.

Novel clinical scoring system to identify patients with pneumothorax with suspicion for Birt-Hogg-Dubé syndrome.

Oxidized regenerated cellulose induces pleural thickening in patients with pneumothorax: possible involvement of the mesothelial-mesenchymal transition.

Development of interstitial pneumonia during treatment with eribulin: a case report.

A method of high-throughput functional evaluation of gene variants of unknown significance in cancer.

Difference of the progression of pulmonary cysts assessed by computed tomography among COPD, lymphangioleiomyomatosis, and Birt-Hogg-Dubé syndrome.

Effect of telling patients their "spirometric-lung-age" on smoking cessation in Japanese smokers.

Prognostic Factors and Efficacy of First-Line Chemotherapy in Patients with Advanced Thymic Carcinoma: A Retrospective Analysis of 286 Patients from NEJ023 Study.

Malignant Pleural Mesothelioma with Bone Marrow Metastases.

The diagnostic yield using ultrasound-guided needle-aspiration for subpleural primary lung cancer is not affected by the radiological properties of the lesions resulting from computed tomography.

Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review.

Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis.

Japanese guideline for the treatment of idiopathic pulmonary fibrosis.

Disseminated non-tuberculous mycobacterial infection caused by anti-interferon-γ autoantibodies in a patient of very advanced age.

COPD assessment test as a possible tool for evaluating health-related quality of life in lymphangioleiomyomatosis.

A Case of a Pregnant Woman Diagnosed as Having -rearranged Lung Adenocarcinoma.

Regional heterogeneity in response of airway epithelial cells to cigarette smoke.

Resistance to molecularly targeted therapy in non-small-cell lung cancer.

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling.

Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Pneumonia.

Difference between two exhaled nitric oxide analyzers, NIOX VERO electrochemical hand-held analyzer and NOA280i chemiluminescence stationary analyzer.

Hydrocarbon pneumonitis caused by the inhalation of wood preservative.

Safety and pharmacokinetics of Alpha-1 MP (Prolastin-C) in Japanese patients with alpha-antitrypsin (AAT) deficiency.

Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E.

Usual Interstitial Pneumonia Pattern in the Lower Lung Lobes as a Prognostic Factor in Idiopathic Pleuroparenchymal Fibroelastosis.

Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.

Germline mutations in lung cancer.

Borderline pulmonary hypertension associated with chronic hypercapnia in chronic pulmonary disease.

Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition.

Polysomnographic features of low arousal threshold in overlap syndrome involving obstructive sleep apnea and chronic obstructive pulmonary disease.

Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.

Management of skin sarcoidosis with minocycline monotherapy.

Specific Features of Fibrotic Lung Fibroblasts Highly Sensitive to Fibrotic Processes Mediated via TGF-β-ERK5 Interaction.

Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration.

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.

Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer.

Age is an independent predictor in pathological diagnosis of sarcoidosis: a retrospective analysis of diagnosis by endobronchial ultrasound-guided transbronchial needle aspiration.

Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation.

Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia.

Gastrointestinal adverse effects of nintedanib and the associated risk factors in patients with idiopathic pulmonary fibrosis.

23-valent pneumococcal polysaccharide vaccine improves survival in dialysis patients by preventing cardiac events.