Robert F. Margolskee

Involvement of T1R3 in calcium-magnesium taste.

Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences.

Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice.

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Action potential-enhanced ATP release from taste cells through hemichannels.

Gustation genetics: sweet gustducin!

Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice.

REEP2 enhances sweet receptor function by recruitment to lipid rafts.

Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells.

A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice.

Major taste loss in carnivorous mammals.

Targeted taste cell-specific overexpression of brain-derived neurotrophic factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells, increases taste bud size, and promotes gustatory innervation.

The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice.

Gustducin couples fatty acid receptors to GLP-1 release in colon.

Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue.

Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Endocrine taste cells.

Bitter and sweet taste receptors regulate human upper respiratory innate immunity.

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.

The bamboo-eating giant panda (Ailuropoda melanoleuca) has a sweet tooth: behavioral and molecular responses to compounds that taste sweet to humans.

Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells.

Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.

Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo.

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds.

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor.

Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus).

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.

Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms.

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.

Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation.

Whole transcriptome profiling of taste bud cells.

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells.

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae.

Gli3 is a negative regulator of Tas1r3-expressing taste cells.

Aggravated gut inflammation in mice lacking the taste signaling protein α-gustducin.

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine.