Seppo Parkkila

Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1.

The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV.

Carbonic anhydrase isozymes IX and XII in gastric tumors.

Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues.

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.

Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs.

Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin.

Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours.

Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa.

Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.

Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.

Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2.

Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus.

Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice.

Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis.

Expression of carbonic anhydrases IX and XII during mouse embryonic development.

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart.

A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system.

Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy.

Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV.

Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse.

Carbonic anhydrase IX in oligodendroglial brain tumors.

The calcium-binding protein S100P in normal and malignant human tissues.

Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas.

Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches.

Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity.

Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.

Expression of iron-related genes in human brain and brain tumors.

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.

Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum.

Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases.

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.

The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney.

Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors.

Phylogeny and expression of carbonic anhydrase-related proteins.

The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.

Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme.

Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study.

Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach.

Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates.

Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren's syndrome.

Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases.

Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva.

Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins.

Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.

Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.

Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.

Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.

Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans.

Hsp27 and its expression pattern in diffusely infiltrating astrocytomas.

Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation.

Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster.

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model.

Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry.

The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.

Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish.

β carbonic anhydrase is required for female fertility in Drosophila melanogaster.

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

Innovative molecular diagnosis of Trichinella species based on β-carbonic anhydrase genomic sequence.

Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes.

Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation.

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.

Identification and inhibition of carbonic anhydrases from nematodes.

Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide.

Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.

Anti-carbonic anhydrase autoantibodies and serum beta-2 microglobulin correlate with the ClinESSDAI score in patients with Sjögren's syndrome.

Carbonic anhydrase II: a novel biomarker for pseudomyxoma peritonei.

Role of carbonic anhydrases in skin wound healing.

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.

Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase.

Surveillance and diagnosis of zoonotic foodborne parasites.

An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii.

Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi.

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.

Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.

Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi.

Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma.

Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies.

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan .

R-Ras regulates vascular permeability, but not overall healing in skin wounds.

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan .

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines.

Discovery of new organoselenium compounds as antileishmanial agents.