Constantinos M. Mikelis

Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro.

Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System.

Extrapulmonary infection in patients with CARD9 deficiency.

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions.

The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

GM-CSF therapy in human caspase recruitment domain-containing protein 9 deficiency.

Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models.

Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.

DNA Repair Response Adaptors: Novel Targets for Vasoproliferative Retinopathy?

In Vitro Spheroid Sprouting Assay of Angiogenesis.

Matrigel Plug Assay for In Vivo Evaluation of Angiogenesis.

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology.

In Vitro Wound Healing Assays to Investigate Epidermal Migration.

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.

Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?

Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis.

Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling.

Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview.

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling.

Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on αβ integrin expression.

Investigating Epidermal Interactions Through an In Vivo Cutaneous Wound-Healing Assay.

In Vivo Ear Sponge Lymphangiogenesis Assay.

Identification of Rho GEF and RhoA Activation by Pull-Down Assays.

Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer.

An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening.

Glycolysis is integral to histamine-induced endothelial hyperpermeability.

Delayed Exercise-induced Upregulation of Angiogenic Proteins and Recovery of Motor Function after Photothrombotic Stroke in Mice.

Advanced bioinformatic analysis and pathway prediction of NSCLC cells upon cisplatin resistance.

Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer.

Targeting the Angiopoietin/Tie Pathway: Prospects for Treatment of Retinal and Respiratory Disorders.

Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish.

MiRNAs as Anti-Angiogenic Adjuvant Therapy in Cancer: Synopsis and Potential.

Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.

Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis.

Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation.

An in vitro model of glucose transporter 1 deficiency syndrome at the blood-brain barrier using induced pluripotent stem cells.

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.

Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery.

Endothelial-Specific Targeting of RhoA Signaling via CD31 Antibody-Conjugated Nanoparticles.

Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.