Bing Sun

Bing Sun is an Associate Research Fellow at the Research center for pharmacology and toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. He received his undergraduate with honors degree from Harbin Medical College, and a Ph.D. from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College.

During Dr. Sun’s Ph.D. training at Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College (2007 to 2010), he developed a keen focus on research that encompasses regulation of Toll like receptors (TLRs) signaling in Sertoli cells in testicular innate immune response. By the well-established TAM (Tyro3, Axl and Mer) triple mutant mice, he found that Growth arrest specific gene 6, one of the TAM receptors, negatively regulated TLR3 signaling in Sertoli cells, which may participate in controlling the testicular innate responses to pathogens. Dr. Sun received a Hong Kong scholar award, and he worked as post-doctoral fellow (2015) at School of Biomedical Sciences, the Chinese University of Hong Kong. He studied the regulation of vascular function in cardiovascular diseases and metabolic disorders.

Dr. Bing’s research is supported by the National Natural Science Foundation of China, the Beijing Municipal Natural Science Foundation, and the Ph.D. Programs Foundation of Ministry of Education of China. Currently his main work is to study the effect of stress on cardiovascular dysfunction and metabolic disorders. Also, his group is trying to find the missing link between obesity and cardiovascular diseases.

Selected Peer-reviewed Publications

1. Jing Xiao, Ting Zhu, Yue-zhang Yin, Bing Sun* Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE(-/-) mice. Eur J Pharmacol. 2018, 833: 441-450.

2. Bing Sun, Jing Xiao, Xiao-Bo Sun, Ying Wu. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into estrogen receptor activation and PI3K/Akt signaling. British Journal of Pharmacology. 2013, 168(7):1758-70. PMID:23170834

3. Jing Xiao, Bing Sun, Ming Li, Ying Wu, Xiao-Bo Sun. A novel adipocytokine visfatin protects against H2O2 -induced myocardial apoptosis: A missing link between obesity and cardiovascular disease. Journal of Cellular Physiology. 2013, 228(3): 495-501. [co-first author] PMID:23065734

4. Bing Sun, Gui-Bo Sun, Jing Xiao, Rong-Chang Chen, Xin Wang, Ying Wu, Li Cao, Zhi-Hong Yang, Xiao-Bo Sun. Isorhamnetin Inhibits H2O2-Induced Activation of the Intrinsic Apoptotic Pathway in H9c2 Cardiomyocytes Through Scavenging Reactive Oxygen Species and ERK Inactivation. Journal of Cellular Biochemistry. 2012, 113(2): 473-485. PMID:21948481

5. Bing Sun, Nan Qi, Tao Shang, Hui Wu, Ting-Ting Deng Dai-Shu Han. Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors. Endocrinology. 2010, 151(6): 2886-97. PMID:20363878

6. Jing Xiao, Gui-Bo Sun, Bing Sun, Ying Wu, Ling He, Xin Wang, Rong-Chang Chen, Li Cao, Xiao-Yu Ren, Xiao-Bo Sun. Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology. 2012, 292 (1): 53-62. PMID:22155320

7. Tao Shang, Xiaoyan Zhang, Tao Wang, Bing Sun, Ting-Ting Deng, Dai-shu Han. Toll-like receptor-initiated testicular innate immune responses in mouse Leydig cells. Endocrinology. 2011, 152(7): 2827-36. PMID:21540291

8. Jing Xiao, Bing Sun, Guo-ping Cai. Transient expression of interferon-inducible p204 in the early stage is required for adipogenesis in 3T3-L1 cells. Endocrinology. 2010, 151(7): 3141-53. PMID:20444940

9. Jing Xiao, Nai-li Wang, Bing Sun, Guo-ping Cai. Estrogen receptor mediates the effects of pseudoprotodiocsin on adipogenesis in 3T3-L1 cells. American Journal of Physiology. Cell Physiology. 2010, 299(1): C128-38. PMID:20427709

10. Ping Xie, Xu Zeng, Jing Xiao, Bing Sun, Dan Yang. Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice, Biochim Biophys Acta, 2014, 1841(12): 1683-1690.

Patents

Bing Sun, Jing Xiao. Application of dioscin compound. (CN107375312)