Drug Research Program,
Division of Pharmaceutical Chemistry and Technology,
Faculty of Pharmacy,
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy
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On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole.
Journal of pharmaceutical sciences Apr, 2003 | Pubmed ID: 12661060
Recent advances in 1,3-dipolar cycloaddition reactions on solid supports.
Molecular diversity , 2005 | Pubmed ID: 15789565
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.
Journal of the American Society for Mass Spectrometry Jun, 2005 | Pubmed ID: 15907705
A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jul-Aug, 2005 | Pubmed ID: 15979536
Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines.
Bioorganic & medicinal chemistry letters Aug, 2005 | Pubmed ID: 15993061
Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors.
Journal of neurochemistry Sep, 2005 | Pubmed ID: 16000156
Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17.
Journal of medicinal chemistry Mar, 2006 | Pubmed ID: 16509597
Solid-phase synthesis of pyrazolopyridines from polymer-bound alkyne and azomethine imines.
Journal of combinatorial chemistry May-Jun, 2006 | Pubmed ID: 16677003
Pharmacological properties of the ubiquitous natural product betulin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Sep, 2006 | Pubmed ID: 16716572
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat.
Anesthesia and analgesia Jun, 2006 | Pubmed ID: 16717324
Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins.
Journal of biochemical and biophysical methods Aug, 2006 | Pubmed ID: 16766039
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays.
Analytical biochemistry Mar, 2007 | Pubmed ID: 17266913
Stereoselective aza Diels-Alder reaction on solid phase: a facile synthesis of hexahydrocinnoline derivatives.
Journal of combinatorial chemistry Mar-Apr, 2007 | Pubmed ID: 17348732
Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives.
Journal of medicinal chemistry May, 2007 | Pubmed ID: 17474732
Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol.
ChemMedChem Jun, 2007 | Pubmed ID: 17479992
Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation.
Biochemical pharmacology Aug, 2007 | Pubmed ID: 17548063
Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7.
Bioorganic chemistry Oct, 2007 | Pubmed ID: 17706742
A new insight into solid-state conformation of macrolide antibiotics.
Bioorganic & medicinal chemistry Jan, 2008 | Pubmed ID: 17936632
Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7.
ChemMedChem Dec, 2007 | Pubmed ID: 17943712
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.
Bioorganic & medicinal chemistry Jan, 2009 | Pubmed ID: 19070498
Synthesis and characterization of hydroxylated mesocarb metabolites for doping control.
Archiv der Pharmazie Apr, 2009 | Pubmed ID: 19340833
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.
Journal of medicinal chemistry Jul, 2009 | Pubmed ID: 19438240
Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jul, 2009 | Pubmed ID: 19447177
Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2009 | Pubmed ID: 19741136
The binding of synthetic retinoids to lipocalin beta-lactoglobulins.
Journal of medicinal chemistry Jan, 2010 | Pubmed ID: 19938842
Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals Mar, 2010 | Pubmed ID: 20007669
Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives.
Bioorganic & medicinal chemistry Feb, 2010 | Pubmed ID: 20116263
Anti-leishmanial activity of betulin derivatives.
The Journal of antibiotics Mar, 2010 | Pubmed ID: 20139867
HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Aug, 2010 | Pubmed ID: 20433920
Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida.
Planta Jan, 2011 | Pubmed ID: 20878179
Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae.
Journal of medicinal chemistry Nov, 2010 | Pubmed ID: 20932010
Synthesis and tautomerization of benzo[cd]azulen-3-ones.
Organic letters Apr, 2011 | Pubmed ID: 21370863
Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.
Bioorganic & medicinal chemistry letters Apr, 2011 | Pubmed ID: 21421315
Current status and future prospects of C1 domain ligands as drug candidates.
Current topics in medicinal chemistry , 2011 | Pubmed ID: 21513495
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells.
PloS one , 2011 | Pubmed ID: 21629792
Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors.
ChemMedChem Sep, 2011 | Pubmed ID: 21721129
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin.
Drug metabolism and disposition: the biological fate of chemicals Nov, 2012 | Pubmed ID: 22912433
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.
PloS one , 2013 | Pubmed ID: 23372764
Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells.
PloS one , 2013 | Pubmed ID: 23405147
Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma.
PloS one , 2013 | Pubmed ID: 23565190
The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells.
Pharmacological research Jul, 2013 | Pubmed ID: 23643828
(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro.
International journal of molecular sciences Jun, 2013 | Pubmed ID: 23739682
Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).
PloS one , 2014 | Pubmed ID: 24879289
Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives.
PloS one , 2014 | Pubmed ID: 25032708
Exploring marine resources for bioactive compounds.
Planta medica Sep, 2014 | Pubmed ID: 25203732
Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction.
Bioorganic & medicinal chemistry Nov, 2014 | Pubmed ID: 25240731
C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities.
Biochemical Society transactions Dec, 2014 | Pubmed ID: 25399568
Synthesis and biological evaluation of 2-arylbenzimidazoles targeting Leishmania donovani.
Bioorganic & medicinal chemistry letters May, 2015 | Pubmed ID: 25827525
Mass-tag enhanced immuno-laser desorption/ionization mass spectrometry for sensitive detection of intact protein antigens.
Analytical chemistry May, 2015 | Pubmed ID: 25867450
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
Journal of medicinal chemistry Jun, 2015 | Pubmed ID: 25906200
Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.
PloS one , 2015 | Pubmed ID: 25965345
Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.
PloS one , 2015 | Pubmed ID: 26075720
New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity.
European journal of medicinal chemistry Sep, 2015 | Pubmed ID: 26241878
Synthesis of 1,3,6-Trisubstituted Azulenes.
The Journal of organic chemistry Nov, 2015 | Pubmed ID: 26528547
Synthesis and Biological Evaluation of 2-Aminobenzothiazole and Benzimidazole Analogs Based on the Clathrodin Structure.
Archiv der Pharmazie Feb, 2016 | Pubmed ID: 26709468
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.
Journal of natural products Feb, 2016 | Pubmed ID: 26849852
Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo.
Journal of natural products Feb, 2016 | Pubmed ID: 26915998
Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones.
Archiv der Pharmazie Sep, 2016 | Pubmed ID: 27404773
Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells.
Advanced healthcare materials Feb, 2017 | Pubmed ID: 27943644
In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells.
Biomaterials 03, 2017 | Pubmed ID: 28081462
Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones.
Organic letters 04, 2017 | Pubmed ID: 28379712
Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs.
Nanomedicine (London, England) Nov, 2017 | Pubmed ID: 28960138
Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel KV10.1.
PloS one , 2017 | Pubmed ID: 29220359
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.
European journal of medicinal chemistry Jan, 2018 | Pubmed ID: 29223098
Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells.
Planta medica Jul, 2018 | Pubmed ID: 29518814
Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.
PloS one , 2018 | Pubmed ID: 29641588
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors.
European journal of medicinal chemistry May, 2018 | Pubmed ID: 29649744
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
Journal of natural products 05, 2018 | Pubmed ID: 29726680
Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice.
Basic & clinical pharmacology & toxicology Nov, 2018 | Pubmed ID: 29781560
Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.
Archives of toxicology 09, 2018 | Pubmed ID: 29987409
Azulene-based compounds for targeting orexin receptors.
European journal of medicinal chemistry Sep, 2018 | Pubmed ID: 30077889
Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1.
Scientific reports 10, 2018 | Pubmed ID: 30374056
Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives.
Marine drugs Dec, 2018 | Pubmed ID: 30513862
Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A.
ACS medicinal chemistry letters Dec, 2018 | Pubmed ID: 30613338
Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark.
The New phytologist 06, 2019 | Pubmed ID: 30724367
Structure-Activity Relationships of 1-Benzoylazulenes at the OX and OX Orexin Receptors.
ChemMedChem May, 2019 | Pubmed ID: 30892823
Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo.
ACS chemical neuroscience Jun, 2019 | Pubmed ID: 31034197
Preparation and Characterization of Dentin Phosphophoryn-Derived Peptide-Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake.
Small (Weinheim an der Bergstrasse, Germany) Jun, 2019 | Pubmed ID: 31062448
Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor.
Science advances May, 2019 | Pubmed ID: 31131322
Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites.
Neuropharmacology Oct, 2019 | Pubmed ID: 31251996
Simple 3D printed stainless steel microreactors for online mass spectrometric analysis.
Heliyon Jul, 2019 | Pubmed ID: 31312730
Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization.
ACS omega Aug, 2018 | Pubmed ID: 31459017
Keni Vidilaseris*,1,
Niklas G. Johansson*,2,
Ainoleena Turku2,
Alexandros Kiriazis2,
Gustav Boije af Gennäs2,
Jari Yli-Kauhaluoma2,
Henri Xhaard2,
Adrian Goldman1,3
1Research Program in Molecular and Integrative Biosciences, University of Helsinki,
2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki,
3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds
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