Motoyuki Otsuka

Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta.

Reduced expression of RAS protein activator like-1 in gastric cancer.

Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines.

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.

Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.

MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators.

Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.

A miRNA machinery component DDX20 controls NF-κB via microRNA-140 function.

MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.

Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation.

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.

Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.

MicroRNAs and liver function.

Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression.

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.

Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.

Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs.

Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.

The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects.

Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA.

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.

Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.

Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.

Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma.

Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA.

ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression.

Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors.

Circulating RNAs as new biomarkers for detecting pancreatic cancer.

Development of a screening method to identify regulators of MICA shedding.

Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7.

MicroRNAs and liver disease.

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1.

Quantitation of circulating satellite RNAs in pancreatic cancer patients.

Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis.

Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system.

Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.

RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis.

CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.

Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer.

DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels.

Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA.

Liver stiffness measurements in chronic hepatitis C: Treatment evaluation and risk assessment.

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells.

Inflammation and de-differentiation in pancreatic carcinogenesis.

Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus.

Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction.

Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels.

Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement.