William P. Schiemann

Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis.

Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta.

Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta.

Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades.

SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system.

Development of human protein reference database as an initial platform for approaching systems biology in humans.

Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.

Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells.

Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor.

Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis.

Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells.

Fibulin-5 promotes wound healing in vivo.

Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling.

Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.

The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta.

Fibulins 3 and 5 antagonize tumor angiogenesis in vivo.

Fibulin-5 function during tumorigenesis.

TGF-beta in cancer and other diseases.

Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells.

Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages.

Role of transforming growth factor-beta in cancer progression.

Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion.

Targeted TGF-beta chemotherapies: friend or foe in treating human malignancies?

Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression.

Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells.

Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism.

Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells.

Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.

The TGF-beta paradox in human cancer: an update.

X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression.

Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors.

Preclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancer.

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling.

Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.

Epithelial-mesenchymal transition in tumor metastasis: a method to the madness.

Mechanisms of the epithelial-mesenchymal transition by TGF-beta.

PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis.

Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation.

The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells.

Colorectal cancer in the cotton top tamarin (Saguinus oedipus): how do they evade liver metastasis?

Transforming growth factor-β and the hallmarks of cancer.

The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells.

Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth.

Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis.

Noncanonical TGF-β signaling during mammary tumorigenesis.

Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells.

Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression.

Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer.

β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.

NetSlim: high-confidence curated signaling maps.

Role of TGF-β and the tumor microenvironment during mammary tumorigenesis.