Jianxun Qi

X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide.

Molecular cloning, expression, purification and crystallographic analysis of PRRSV 3CL protease.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta2-microglobulin.

Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldariusTc-12-31.

Crystallization and crystallographic analysis of human NUDT16.

Crystallization and preliminary crystallographic analysis of recombinant immunoglobulin G-binding protein from Streptococcus suis.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Streptococcus suis serotype 2.

Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4.

Crystallization and preliminary X-ray analysis of the V domain of human nectin-2.

[Purification, crystallographic analysis of rhesus MHC-I Mamu-A*02 complexed with simian immunodeficiency virus nonapeptide].

Complex assembly, crystallization and preliminary X-ray crystallographic studies of duck MHC class I molecule.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2.

Crystallization and preliminary crystallographic studies of the C-terminal domain of outer membrane protein A from enterohaemorrhagic Escherichia coli.

The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes.

Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus.

A dimeric structure of PD-L1: functional units or evolutionary relics?

Crystallization and preliminary X-ray studies of native and mutant intimin from enterohaemorrhagic Escherichia coli.

[Expression and crystallographic studies of a fungal immunomodulatory protein LZ-8 from a medicinal fungus Ganoderma lucidum].

Structural analysis of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions.

Two distinct conformations of a rinderpest virus epitope presented by bovine major histocompatibility complex class I N*01801: a host strategy to present featured peptides.

Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.

Crystallization and preliminary X-ray diffraction analysis of cyclic imide hydrolase (CIH) from Pseudomonas putida YZ-26.

Complex assembly, crystallization and preliminary X-ray crystallographic studies of the swine major histocompatibility complex molecule SLA-1*1502.

LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.

Diverse peptide presentation of rhesus macaque major histocompatibility complex class I Mamu-A 02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus.

Insight into the interaction of metal ions with TroA from Streptococcus suis.

Plasticity of human CD8αα binding to peptide-HLA-A*2402.

Influenza A virus N5 neuraminidase has an extended 150-cavity.

A novel "open-form" structure of sortaseC from Streptococcus suis.

Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design.

Crystallization and preliminary X-ray crystallographic studies of swine CD8α.

Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides.

Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes.

Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition.

Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus.

Expression, crystallization and preliminary crystallographic analysis of C-reactive protein from zebrafish.

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.

Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines.

Expression, refolding and preliminary X-ray crystallographic analysis of equine MHC class I molecule complexed with an EIAV-Env CTL epitope.

Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226.

Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of subtype H16 has an alpha-helix structure in its cleavage site with inefficient HA1/HA2 cleavage.

Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus.

Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals.

Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens.

An octamer of enolase from Streptococcus suis.

Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4.

Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism.

Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution.

Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding.

Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes.

An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level.

Structure and receptor binding specificity of hemagglutinin H13 from avian influenza A virus H13N6.

Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut).

Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.

Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding.

Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.

Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus.

Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses.

Crystal structure of the interferon gamma receptor alpha chain from chicken reveals an undetected extra helix compared with the human counterparts.

The N-terminal domain of PA from bat-derived influenza-like virus H17N10 has endonuclease activity.

Nα-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted nα-acetylpeptide presentation.

PILRα and PILRβ have a siglec fold and provide the basis of binding to sialic acid.

Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle.

Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex.

Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.

Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition.

Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses.

Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus.

Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces.

Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference.

Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor.

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.

Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors.

Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles.

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.

An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.

Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses.

The structural basis of chicken, swine and bovine CD8αα dimers provides insight into the co-evolution with MHC I in endotherm species.

Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody.

The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone.

Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses.

Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I.

Functional and Structural Characterization of P[19] Rotavirus VP8* Interaction with Histo-blood Group Antigens.

Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.

Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure.

Molecular basis of antibody-mediated neutralization and protection against flavivirus.

Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor.

Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs.

Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.

Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies.

Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis.

Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus.

An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.

The crystal structure of Zika virus NS5 reveals conserved drug targets.

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.

Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein.

Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab.

Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D.

Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures.

Conserved Vδ1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by δ/αβ T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs.

Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus.

Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4.

Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope.

Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies.

The Structure of the MHC Class I Molecule of Bony Fishes Provides Insights into the Conserved Nature of the Antigen-Presenting System.

The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae.

Structures of human-infecting fusogens support a common ancestor with insect baculovirus.

Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design.

Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus.

Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4.

Crystal Structure of the Capsid Protein from Zika Virus.

Discovery and Analysis of Invertebrate IgV-C2 Structure from Amphioxus Provides Insight into the Evolution of the Ig Superfamily.

Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT.

Human Group C Rotavirus VP8*s Recognize Type A Histo-Blood Group Antigens as Ligands.

Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China.

Glycan Binding Specificity and Mechanism of Human and Porcine P[6]/P[19] Rotavirus VP8*s.

Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.

Structural and functional insights into MCR-2 mediated colistin resistance.

An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.

Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.

Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.

Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.

Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.

Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.

Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.

Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.

Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain.

Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli.

The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.

Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses.

Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

Structural insight into RNA synthesis by influenza D polymerase.

Salt bridge-forming residues positioned over viral peptides presented by MHC class I impacts T-cell recognition in a binding-dependent manner.

Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex.

Postfusion structure of human-infecting Bourbon virus envelope glycoprotein.

Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4.

Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.

Structural Basis of Glycan Recognition in Globally Predominant Human P[8] Rotavirus.

Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.

Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin.

Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species.

Cryo-EM Structure of the African Swine Fever Virus.

Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody.

Structural insight into arenavirus replication machinery.

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2.

The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives.

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.

Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry.

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2.

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS.

Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1.

Computational predicting the human infectivity of H7N9 influenza viruses isolated from avian hosts.

Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species.

The crystal structure of the emerging human-infecting hepatitis E virus E2s protein.

Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy.

Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.

Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design.

Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy.

Cryo-EM structure of the varicella-zoster virus A-capsid.

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2.

Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus.

N-glycosylation of PD-1 promotes binding of camrelizumab.

Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses.

Cross-species recognition of SARS-CoV-2 to bat ACE2.

A broadly protective antibody that targets the flavivirus NS1 protein.

Human group A rotavirus P[25] VP8* specifically binds to A-type histo-blood group antigen.

Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir.

Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.