UCL Institute of Ophthalmology
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SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics.
Journal of neuroimmunology Dec, 1996 | Pubmed ID: 8982103
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2001 | Pubmed ID: 11504951
Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies.
Investigative ophthalmology & visual science Feb, 2002 | Pubmed ID: 11818403
Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2002 | Pubmed ID: 11937568
Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2002 | Pubmed ID: 12153986
Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated.
Brain research. Molecular brain research Sep, 2002 | Pubmed ID: 12399107
Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier.
Vascular pharmacology Jun, 2002 | Pubmed ID: 12529926
Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2003 | Pubmed ID: 12626426
Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells.
Neuroscience letters Jun, 2003 | Pubmed ID: 12782340
Potential of statins for the treatment of multiple sclerosis.
The Lancet. Neurology Jan, 2003 | Pubmed ID: 12849290
Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2003 | Pubmed ID: 12902516
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
Investigative ophthalmology & visual science Feb, 2004 | Pubmed ID: 14744914
Basement membrane-dependent modification of phenotype and gene expression in human retinal pigment epithelial ARPE-19 cells.
Investigative ophthalmology & visual science Aug, 2004 | Pubmed ID: 15277505
Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2005 | Pubmed ID: 15699169
Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation.
Cellular and molecular neurobiology Feb, 2005 | Pubmed ID: 15962512
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
Nature reviews. Immunology May, 2006 | Pubmed ID: 16639429
Statins and the vascular endothelial inflammatory response.
Trends in immunology Feb, 2007 | Pubmed ID: 17197237
Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina.
Experimental neurology May, 2007 | Pubmed ID: 17362933
Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques.
The European journal of neuroscience Apr, 2007 | Pubmed ID: 17439483
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17921253
Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration.
Journal of cell science Jan, 2008 | Pubmed ID: 18096689
ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration.
Molecular biology of the cell Feb, 2009 | Pubmed ID: 19073885
Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina.
Molecular biology of the cell Sep, 2009 | Pubmed ID: 19587120
Positional averaging explains crowding with letter-like stimuli.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19617570
Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging.
The Journal of experimental medicine Aug, 2009 | Pubmed ID: 19667063
Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19850870
The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration.
Molecular biology of the cell Mar, 2010 | Pubmed ID: 20089843
Crowding changes appearance.
Current biology : CB Mar, 2010 | Pubmed ID: 20206527
Probabilistic, positional averaging predicts object-level crowding effects with letter-like stimuli.
Journal of vision Aug, 2010 | Pubmed ID: 20884479
Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain.
Neuropathology and applied neurobiology Feb, 2011 | Pubmed ID: 20946472
Analysis of candidate genes for macular telangiectasia type 2.
Molecular vision , 2010 | Pubmed ID: 21179236
The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.
Molecular vision , 2011 | Pubmed ID: 21738400
Crowding is tuned for perceived (not physical) location.
Journal of vision Aug, 2011 | Pubmed ID: 21824980
Apelin is required for non-neovascular remodeling in the retina.
The American journal of pathology Jan, 2012 | Pubmed ID: 22067912
A common visual metric for approximate number and density.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22106276
Crowding follows the binding of relative position and orientation.
Journal of vision Mar, 2012 | Pubmed ID: 22438467
The neural correlates of crowding-induced changes in appearance.
Current biology : CB Jul, 2012 | Pubmed ID: 22658599
Number and density discrimination rely on a common metric: Similar psychophysical effects of size, contrast, and divided attention.
Journal of vision Jun, 2012 | Pubmed ID: 22665458
Visual acuity, crowding, and stereo-vision are linked in children with and without amblyopia.
Investigative ophthalmology & visual science Nov, 2012 | Pubmed ID: 23074213
Rationale and design of the PRognostic Importance of MIcrovascular Dysfunction in asymptomatic patients with Aortic Stenosis (PRIMID-AS): a multicentre observational study with blinded investigations.
BMJ open Dec, 2013 | Pubmed ID: 24353258
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
Lancet (London, England) Jun, 2014 | Pubmed ID: 24655729
Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.
Journal of cell science Sep, 2014 | Pubmed ID: 25002404
Crowding is reduced by onset transients in the target object (but not in the flankers).
Journal of vision Aug, 2014 | Pubmed ID: 25086085
Differential apicobasal VEGF signaling at vascular blood-neural barriers.
Developmental cell Sep, 2014 | Pubmed ID: 25175707
Foveal target repetitions reduce crowding.
Journal of vision Oct, 2014 | Pubmed ID: 25294741
Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial.
Journal of the American College of Cardiology Mar, 2015 | Pubmed ID: 25766941
Splenic Switch-off: A Tool to Assess Stress Adequacy in Adenosine Perfusion Cardiac MR Imaging.
Radiology Sep, 2015 | Pubmed ID: 25923223
Mineralocorticoid receptor antagonist pretreatment to MINIMISE reperfusion injury after ST-elevation myocardial infarction (the MINIMISE STEMI Trial): rationale and study design.
Clinical cardiology May, 2015 | Pubmed ID: 25990305
Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2015 | Pubmed ID: 26324770
The fetal mouse metatarsal bone explant as a model of angiogenesis.
Nature protocols Oct, 2015 | Pubmed ID: 26334866
Complete Versus Lesion-Only Primary PCI: The Randomized Cardiovascular MR CvLPRIT Substudy.
Journal of the American College of Cardiology Dec, 2015 | Pubmed ID: 26700834
Categorical information influences conscious perception: An interaction between object-substitution masking and repetition blindness.
Attention, perception & psychophysics 05, 2016 | Pubmed ID: 26902249
Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.
Ecancermedicalscience , 2016 | Pubmed ID: 27110286
Infarct Size Following Treatment With Second- Versus Third-Generation P2Y12 Antagonists in Patients With Multivessel Coronary Disease at ST-Segment Elevation Myocardial Infarction in the CvLPRIT Study.
Journal of the American Heart Association 05, 2016 | Pubmed ID: 27247336
Cortical idiosyncrasies predict the perception of object size.
Nature communications 06, 2016 | Pubmed ID: 27357864
Childhood amblyopia: current management and new trends.
British medical bulletin 09, 2016 | Pubmed ID: 27543498
The orientation selectivity of face identification.
Scientific reports Sep, 2016 | Pubmed ID: 27677359
Infarct size following complete revascularization in patients presenting with STEMI: a comparison of immediate and staged in-hospital non-infarct related artery PCI subgroups in the CvLPRIT study.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Nov, 2016 | Pubmed ID: 27842548
Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) Study.
European heart journal Apr, 2017 | Pubmed ID: 28204448
Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions.
Journal of immunology (Baltimore, Md. : 1950) 05, 2017 | Pubmed ID: 28373581
Variations in crowding, saccadic precision, and spatial localization reveal the shared topology of spatial vision.
Proceedings of the National Academy of Sciences of the United States of America 04, 2017 | Pubmed ID: 28396415
Binocular Therapy for Childhood Amblyopia Improves Vision Without Breaking Interocular Suppression.
Investigative ophthalmology & visual science 06, 2017 | Pubmed ID: 28614556
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.
Fluids and barriers of the CNS Nov, 2017 | Pubmed ID: 29110676
Computational tools for clinical support: a multi-scale compliant model for haemodynamic simulations in an aortic dissection based on multi-modal imaging data.
Journal of the Royal Society, Interface 11, 2017 | Pubmed ID: 29118115
Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.
Fluids and barriers of the CNS 01, 2018 | Pubmed ID: 29329565
Myocardial Scar and Mortality in Severe Aortic Stenosis.
Circulation 10, 2018 | Pubmed ID: 30002099
Crowding for faces is determined by visual (not holistic) similarity: Evidence from judgements of eye position.
Scientific reports 08, 2018 | Pubmed ID: 30135454
Mineralocorticoid receptor antagonist pre-treatment and early post-treatment to minimize reperfusion injury after ST-elevation myocardial infarction: The MINIMIZE STEMI trial.
American heart journal 05, 2019 | Pubmed ID: 30893577
Rationale and design of the randomized, controlled Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis (EVOLVED) trial.
American heart journal 06, 2019 | Pubmed ID: 30978556
Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 05, 2019 | Pubmed ID: 31072935
Population receptive field estimates for motion-defined stimuli.
NeuroImage 10, 2019 | Pubmed ID: 31158480
Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease.
The New England journal of medicine 06, 2019 | Pubmed ID: 31216398
Sex differences in left ventricular remodelling, myocardial fibrosis and mortality after aortic valve replacement.
Heart (British Cardiac Society) 12, 2019 | Pubmed ID: 31467152
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
Lancet (London, England) 10, 2019 | Pubmed ID: 31500849
A Multicenter, Scan-Rescan, Human and Machine Learning CMR Study to Test Generalizability and Precision in Imaging Biomarker Analysis.
Circulation. Cardiovascular imaging 10, 2019 | Pubmed ID: 31547689
Extracellular Myocardial Volume in Patients With Aortic Stenosis.
Journal of the American College of Cardiology 01, 2020 | Pubmed ID: 31976869
Dissociable effects of visual crowding on the perception of color and motion.
Proceedings of the National Academy of Sciences of the United States of America 04, 2020 | Pubmed ID: 32193344
T mapping performance and measurement repeatability: results from the multi-national T mapping standardization phantom program (T1MES).
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 05, 2020 | Pubmed ID: 32375896
A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions.
Diabetes 11, 2020 | Pubmed ID: 32887674
Evaluation of real-world early response of DMO to aflibercept therapy to inform future clinical trial design of novel investigational agents.
Scientific reports 10, 2020 | Pubmed ID: 33020570
Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells.
Cells 12, 2020 | Pubmed ID: 33371217
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.
Journal of neuroinflammation Feb, 2021 | Pubmed ID: 33602234
Topographical Response of Retinal Neovascularization to Aflibercept or Panretinal Photocoagulation in Proliferative Diabetic Retinopathy: Post Hoc Analysis of the CLARITY Randomized Clinical Trial.
JAMA ophthalmology May, 2021 | Pubmed ID: 33704351
Diagnosis and risk stratification in hypertrophic cardiomyopathy using machine learning wall thickness measurement: a comparison with human test-retest performance.
The Lancet. Digital health 01, 2021 | Pubmed ID: 33735065
Regional variation in cardiovascular magnetic resonance service delivery across the UK.
Heart (British Cardiac Society) 12, 2021 | Pubmed ID: 33766986
Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers.
JACC. Cardiovascular imaging 11, 2021 | Pubmed ID: 33975819
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 06, 2021 | Pubmed ID: 34112195
Heritable functional architecture in human visual cortex.
NeuroImage 10, 2021 | Pubmed ID: 34153449
Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis.
Journal of the American College of Cardiology 08, 2021 | Pubmed ID: 34353531
Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target.
RSC chemical biology Aug, 2021 | Pubmed ID: 34458833
The "Neuro-Glial-Vascular" Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34646826
Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy.
Basic research in cardiology 10, 2021 | Pubmed ID: 34648075
Phenotyping hypertrophic cardiomyopathy using cardiac diffusion magnetic resonance imaging: the relationship between microvascular dysfunction and microstructural changes.
European heart journal. Cardiovascular Imaging Oct, 2021 | Pubmed ID: 34694365
CCL4 induces inflammatory signalling and barrier disruption in the neurovascular endothelium.
Brain, behavior, & immunity - health Dec, 2021 | Pubmed ID: 34755124
Eye movements elevate crowding in idiopathic infantile nystagmus syndrome.
Journal of vision Dec, 2021 | Pubmed ID: 34935877
LRG1 as a novel therapeutic target in eye disease.
Eye (London, England) Jan, 2022 | Pubmed ID: 34987199
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