David Hercher
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
David Hercher’s main research focus is the investigation of regenerative processes after injuries with special emphasis on the nervous system, the elucidation of modes of action of mechanical stimuli on Schwann cells and tissues as well as non-viral gene therapy and novel imaging modalities and their application in the field of regenerative medicine. His most important scientific findings are the phenotypical commitment of motor and sensory Schwann cells as well as the development of a novel contrast agent-enhanced µCT 3D histology method for application in peripheral nerve regeneration as well as novel findings of functional regeneration using automated gait analysis.
Spatiotemporally limited BDNF and GDNF overexpression rescues motoneurons destined to die and induces elongative axon growth.
Experimental neurology Nov, 2014 | Pubmed ID: 24873730
Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture.
Cytotherapy 06, 2016 | Pubmed ID: 27068763
A Noninvasive In Vitro Monitoring System Reporting Skeletal Muscle Differentiation.
Tissue engineering. Part C, Methods 01, 2017 | Pubmed ID: 27901409
Pushing the Right Buttons: Improving Efficacy of Therapeutic DNA Vectors.
Tissue engineering. Part B, Reviews 06, 2018 | Pubmed ID: 29264951
Iodine-Enhanced Micro-CT Imaging of Soft Tissue on the Example of Peripheral Nerve Regeneration.
Contrast media & molecular imaging , 2019 | Pubmed ID: 31049044
Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat.
Frontiers in cellular neuroscience , 2019 | Pubmed ID: 31139050
Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.
The American journal of sports medicine 07, 2019 | Pubmed ID: 31206305
Motor and sensory Schwann cell phenotype commitment is diminished by extracorporeal shockwave treatment in vitro.
Journal of the peripheral nervous system : JPNS 03, 2020 | Pubmed ID: 31983073
The course of recovery of locomotor function over a 10-week observation period in a rat model of femoral nerve resection and autograft repair.
Brain and behavior Apr, 2020 | Pubmed ID: 32097542
Evaluation of BMP-2 Minicircle DNA for Enhanced Bone Engineering and Regeneration.
Current gene therapy , 2020 | Pubmed ID: 32338217
Use of the CatWalk gait analysis system to assess functional recovery in rodent models of peripheral nerve injury - a systematic review.
Journal of neuroscience methods Nov, 2020 | Pubmed ID: 32755615
Shock waves promote spinal cord repair via TLR3.
JCI insight Aug, 2020 | Pubmed ID: 32759498
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