Jose L. Jorcano

Modulation of cell proliferation by cytokeratins K10 and K16.

Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes.

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest.

Functional roles of Akt signaling in mouse skin tumorigenesis.

Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays.

The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis.

Severe abnormalities in the oral mucosa induced by suprabasal expression of epidermal keratin K10 in transgenic mice.

Beyond structure: do intermediate filaments modulate cell signalling?

Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis.

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.

Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis.

A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination.

Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor.

Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice.

Long-term engraftment of single genetically modified human epidermal holoclones enables safety pre-assessment of cutaneous gene therapy.

Modeling normal and pathological processes through skin tissue engineering.

IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.

IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.

Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors.

Tumor initiation by skin Ha-ras-ment.