Gregor Sersa

Effective gene transfer to solid tumors using different nonviral gene delivery techniques: electroporation, liposomes, and integrin-targeted vector.

Schedule-dependent interaction between vinblastine and cisplatin in Ehrlich ascites tumors in mice.

Optimisation of pulse parameters in vitro for in vivo electrochemotherapy.

Oxygenation and blood flow in tumors treated with hydralazine: evaluation with a novel luminescence-based fiber-optic sensor.

Effect of hydralazine on blood flow, oxygenation, and interstitial fluid pressure in subcutaneous tumors.

Perturbation of blood flow as a mechanism of anti-tumour action of direct current electrotherapy.

Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin.

Effects of electrogenetherapy with p53wt combined with cisplatin on curvival of human tumor cell lines with different p53 status.

EPR oximetry of tumors in vivo in cancer therapy.

Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer.

Antitumour effectiveness of hyperthermia is potentiated by local application of electric pulses to LPB tumours in mice.

Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distribution.

Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy.

The effect of high frequency electric pulses on muscle contractions and antitumor efficiency in vivo for a potential use in clinical electrochemotherapy.

Effective treatment of perianal tumors in dogs with electrochemotherapy.

Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice.

Sequence and time dependence of transfection efficiency of electrically-assisted gene delivery to tumors in mice.

Cytotoxicity of different platinum (II) analogues to human tumour cell lines in vitro and murine tumour in vivo alone or combined with electroporation.

In vivo imaging of tumor growth after electrochemotherapy with cisplatin.

The endothelial cytoskeleton as a target of electroporation-based therapies.

Electrogene therapy with p53 of murine sarcomas alone or combined with electrochemotherapy using cisplatin.

Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy.

Electrotransfer of therapeutic molecules into tissues.

Dynamic contrast enhanced MRI of mouse fibrosarcoma using small-molecular and novel macromolecular contrast agents.

Gene electrotransfer into murine skeletal muscle: a systematic analysis of parameters for long-term gene expression.

The effect of electroporation pulses on functioning of the heart.

Electrode commutation sequence for honeycomb arrangement of electrodes in electrochemotherapy and corresponding electric field distribution.

Electrochemotherapy compared to surgery for treatment of canine mast cell tumours.

Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy.

Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells.

Local and systemic antitumor effect of intratumoral and peritumoral IL-12 electrogene therapy on murine sarcoma.

Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas.

Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model.

Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy.

Metastatic potential of melanoma cells is not affected by electrochemotherapy.

Irradiation, cisplatin, and 5-azacytidine upregulate cytomegalovirus promoter in tumors and muscles: implementation of non-invasive fluorescence imaging.

Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases.

Cancer electrogene therapy with interleukin-12.

Robustness of treatment planning for electrochemotherapy of deep-seated tumors.

Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic field.

The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo.

Hyaluronidase and collagenase increase the transfection efficiency of gene electrotransfer in various murine tumors.

Electrochemotherapy of chest wall breast cancer recurrence.

Patient-specific treatment planning of electrochemotherapy: procedure design and possible pitfalls.

Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinoma.

In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: a study in a dorsal window chamber in mice.

Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression.

Radiotherapy in combination with vascular-targeted therapies.

Study of radiation induced changes of phosphorus metabolism in mice by (31)P NMR spectroscopy.

Magnetic nanoparticles as targeted delivery systems in oncology.

Electrogene therapy with interleukin-12 in canine mast cell tumors.

Assessment of the tumourigenic and metastatic properties of SK-MEL28 melanoma cells surviving electrochemotherapy with bleomycin.

Intravital microscopy at the single vessel level brings new insights of vascular modification mechanisms induced by electropermeabilization.

Contrasting effect of recombinant human erythropoietin on breast cancer cell response to cisplatin induced cytotoxicity.

IL-12 based gene therapy in veterinary medicine.

Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma.

Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity.

Tumor size and effectiveness of electrochemotherapy.

Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels.

Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth.

Biological properties of melanoma and endothelial cells after plasmid AMEP gene electrotransfer depend on integrin quantity on cells.

Planning of electroporation-based treatments using Web-based treatment-planning software.

Magnetofection: a reproducible method for gene delivery to melanoma cells.

Electroporation-based treatment planning for deep-seated tumors based on automatic liver segmentation of MRI images.

Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study.

In vivo real-time monitoring system of electroporation mediated control of transdermal and topical drug delivery.

Electrochemotherapy with intravenous bleomycin injection: an observational study in superficial squamous cell carcinoma in cats.

A novel method for speciation of Pt in human serum incubated with cisplatin, oxaliplatin and carboplatin by conjoint liquid chromatography on monolithic disks with UV and ICP-MS detection.

Determination of vinblastine in tumour tissue with liquid chromatography-high resolution mass spectrometry.

Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model.

Changing electrode orientation, but not pulse polarity, increases the efficacy of gene electrotransfer to tumors in vivo.

Schedule-dependent interaction between vinblastine and irradiation in experimental sarcoma.

Electrochemotherapy: from the drawing board into medical practice.

Intraoperative electrochemotherapy of colorectal liver metastases.

A cell-based biosensor system HepG2CDKN1A-DsRed for rapid and simple detection of genotoxic agents.

Electroporation-based technologies for medicine: principles, applications, and challenges.

Modulation of activity of known cytotoxic ruthenium(III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo.

Electrochemotherapy in non-melanoma head and neck cancers: a retrospective analysis of the treated cases.

Inhibitor of endocytosis impairs gene electrotransfer to mouse muscle in vivo.

Mcam Silencing With RNA Interference Using Magnetofection has Antitumor Effect in Murine Melanoma.

Endoglin silencing has significant antitumor effect on murine mammary adenocarcinoma mediated by vascular targeted effect.

Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness.

Improved Specificity of Gene Electrotransfer to Skin Using pDNA Under the Control of Collagen Tissue-Specific Promoter.

Gene Electrotransfer of Canine Interleukin 12 into Canine Melanoma Cell Lines.

Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity.

Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects.

Endoglin (CD105) Silencing Mediated by shRNA Under the Control of Endothelin-1 Promoter for Targeted Gene Therapy of Melanoma.

Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer.

Coupling treatment planning with navigation system: a new technological approach in treatment of head and neck tumors by electrochemotherapy.

Electrochemotherapy of colorectal liver metastases--an observational study of its effects on the electrocardiogram.

Variation in dielectric properties due to pathological changes in human liver.

Clinical potential of electroporation for gene therapy and DNA vaccine delivery.

Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects.

Radioactivity of cigarettes and the importance of (210)Po and thorium isotopes for radiation dose assessment due to smoking.

Bleomycin pharmacokinetics of bolus bleomycin dose in elderly cancer patients treated with electrochemotherapy.

Magnetic field contributes to the cellular uptake for effective therapy with magnetofection using plasmid DNA encoding against Mcam in B16F10 melanoma in vivo.

Recommendations for improving the quality of reporting clinical electrochemotherapy studies based on qualitative systematic review.

Effectiveness of electrochemotherapy after IFN-α adjuvant therapy of melanoma patients.

Electrochemotherapy by pulsed electromagnetic field treatment (PEMF) in mouse melanoma B16F10 in vivo.

Cytotoxic trans-platinum(II) complex with 3-hydroxymethylpyridine: Synthesis, X-ray structure and biological activity evaluation.

European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer.

Bystander Effect Induced by Electroporation is Possibly Mediated by Microvesicles and Dependent on Pulse Amplitude, Repetition Frequency and Cell Type.

Electrotransfer parameters as a tool for controlled and targeted gene expression in skin.

Identification and quantification of bleomycin in serum and tumor tissue by liquid chromatography coupled to high resolution mass spectrometry.

Electrochemotherapy with bleomycin is effective in BRAF mutated melanoma cells and interacts with BRAF inhibitors.