Department of Orthopaedic Surgery,
McGowan Institute for Regenerative Medicine
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Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential.
Biomaterials Jun, 2012 | Pubmed ID: 22459197
Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture.
Biomaterials Jan, 2013 | Pubmed ID: 23092861
Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix.
Biomaterials Dec, 2013 | Pubmed ID: 24044998
Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution.
Tissue engineering. Part A Sep, 2014 | Pubmed ID: 24575844
Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β.
Molecular pharmaceutics Jul, 2014 | Pubmed ID: 24830762
Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases.
Experimental biology and medicine (Maywood, N.J.) Sep, 2014 | Pubmed ID: 24994814
In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold.
Tissue engineering. Part A Jul, 2015 | Pubmed ID: 25813386
Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering.
Frontiers in bioengineering and biotechnology , 2015 | Pubmed ID: 26347860
Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering.
Acta biomaterialia Apr, 2016 | Pubmed ID: 26945631
Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells.
Tissue engineering. Part A Feb, 2017 | Pubmed ID: 27809678
Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness.
Acta biomaterialia Aug, 2017 | Pubmed ID: 28611002
One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction.
Molecular therapy. Methods & clinical development Dec, 2017 | Pubmed ID: 29018836
Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo.
Acta biomaterialia Mar, 2018 | Pubmed ID: 29317369
Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells.
Stem cell research & therapy Apr, 2018 | Pubmed ID: 29615119
Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing.
Biomaterials May, 2019 | Pubmed ID: 29980291
Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β.
Acta biomaterialia Jan, 2019 | Pubmed ID: 30458242
Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway.
Biomaterials Feb, 2019 | Pubmed ID: 30544046
Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect.
Journal of tissue engineering and regenerative medicine Aug, 2019 | Pubmed ID: 31066519
Transplantation of adult spinal cord tissue: Transection spinal cord repair and potential clinical translation.
Science China. Life sciences Jun, 2019 | Pubmed ID: 31124004
A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold.
Stem cells international , 2019 | Pubmed ID: 31149016
The efficacy and safety of tranexamic acid for reducing blood loss following simultaneous bilateral total knee arthroplasty: a multicenter retrospective study.
BMC musculoskeletal disorders Jul, 2019 | Pubmed ID: 31299945
Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix.
Biomaterials Oct, 2019 | Pubmed ID: 31310952
Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold.
Stem cell research & therapy Aug, 2019 | Pubmed ID: 31412905
Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production.
Journal of orthopaedic translation Jul, 2019 | Pubmed ID: 31508317
A Cellularized Biphasic Implant Based on a Bioactive Silk Fibroin Promotes Integration and Tissue Organization during Osteochondral Defect Repair in a Porcine Model.
International journal of molecular sciences Oct, 2019 | Pubmed ID: 31627374
Infiltration and In-Tissue Polymerization of Photocross-Linked Hydrogel for Effective Fixation of Implants into Cartilage-An In Vitro Study.
ACS omega Nov, 2019 | Pubmed ID: 31737812
Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs.
Frontiers in bioengineering and biotechnology , 2019 | Pubmed ID: 31921815
Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance.
Journal of biomedical materials research. Part A Apr, 2020 | Pubmed ID: 31925910
Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels.
Acta biomaterialia Mar, 2020 | Pubmed ID: 32035282
Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior.
Arthritis research & therapy Feb, 2020 | Pubmed ID: 32087740
Chondroinductive factor-free chondrogenic differentiation of human mesenchymal stem cells in graphene oxide-incorporated hydrogels.
Journal of materials chemistry. B Feb, 2018 | Pubmed ID: 32254371
TGF-β1 plays a protective role in glucocorticoid-induced dystrophic calcification.
Bone Jul, 2020 | Pubmed ID: 32259685
Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional Bone Model.
Tissue engineering. Part A Oct, 2020 | Pubmed ID: 32312178
Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties.
Advanced biosystems Dec, 2019 | Pubmed ID: 32648682
Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors .
Biomolecules Jul, 2020 | Pubmed ID: 32709032
Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models.
Biology Jul, 2020 | Pubmed ID: 32751156
Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice.
Stem cells translational medicine Dec, 2020 | Pubmed ID: 32785966
Mesenchymal stem cell-derived extracellular matrix (mECM): a bioactive and versatile scaffold for musculoskeletal tissue engineering.
Biomedical materials (Bristol, England) Dec, 2020 | Pubmed ID: 32906098
Role of mitochondria in mediating chondrocyte response to mechanical stimuli.
Life sciences Dec, 2020 | Pubmed ID: 33086121
Dead muscle tissue promotes dystrophic calcification by lowering circulating TGF-β1 level.
Bone & joint research Nov, 2020 | Pubmed ID: 33135464
Current Models for Development of Disease-Modifying Osteoarthritis Drugs.
Tissue engineering. Part C, Methods Feb, 2021 | Pubmed ID: 33403944
Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling.
Handbook of experimental pharmacology , 2021 | Pubmed ID: 33471201
Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2021 | Pubmed ID: 33617078
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From Expanded Human Chondrocytes.
Frontiers in bioengineering and biotechnology , 2021 | Pubmed ID: 33996787
The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles.
Biomedicines May, 2021 | Pubmed ID: 34062822
Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs.
Science China. Life sciences Feb, 2022 | Pubmed ID: 34109475
Dynamic loading enhances chondrogenesis of human chondrocytes within a biodegradable resilient hydrogel.
Biomaterials science Jul, 2021 | Pubmed ID: 34109952
Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells.
Stem cell research & therapy Jun, 2021 | Pubmed ID: 34127047
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries.
Frontiers in pharmacology , 2021 | Pubmed ID: 34220525
Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway.
Biomaterials Oct, 2021 | Pubmed ID: 34464823
Novel role of estrogen receptor-α on regulating chondrocyte phenotype and response to mechanical loading.
Osteoarthritis and cartilage Feb, 2022 | Pubmed ID: 34767957
Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles.
International journal of molecular sciences Nov, 2021 | Pubmed ID: 34884641
Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering.
Frontiers in cell and developmental biology , 2022 | Pubmed ID: 35141220
Engineering pre-vascularized bone-like tissue from human mesenchymal stem cells through simulating endochondral ossification.
Biomaterials Apr, 2022 | Pubmed ID: 35259584
Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) Jul, 2022 | Pubmed ID: 35436042
Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix.
Acta biomaterialia Sep, 2022 | Pubmed ID: 35779770
Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models.
Stem cell research & therapy Aug, 2022 | Pubmed ID: 35927702
Aberrant Expression of and in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors.
Cells Aug, 2022 | Pubmed ID: 35954211
Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential.
Trends in biotechnology Aug, 2022 | Pubmed ID: 35995600
Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes.
Biology Jun, 2022 | Pubmed ID: 36101377
Experimental models to study osteoarthritis pain and develop therapeutics.
Osteoarthritis and cartilage open Dec, 2022 | Pubmed ID: 36474784
Differences in the intrinsic chondrogenic potential of human mesenchymal stromal cells and iPSC-derived multipotent cells.
Clinical and translational medicine Dec, 2022 | Pubmed ID: 36536500
PEG Reinforced Scaffold Promotes Uniform Distribution of Human MSC-Created Cartilage Matrix.
Gels (Basel, Switzerland) Dec, 2022 | Pubmed ID: 36547318
In vitro study to identify ligand-independent function of estrogen receptor-α in suppressing DNA damage-induced chondrocyte senescence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2023 | Pubmed ID: 36622202
Meagan J. Makarcyzk1,2,
Zhong Alan Li1,3,
Ilhan Yu1,
Haruyo Yagi1,
Xiurui Zhang1,
Lauren Yocum1,
Eileen Li1,
Madalyn R. Fritch1,
Qi Gao4,
Bruce A. Bunnell5,
Stuart B. Goodman4,6,
Rocky S. Tuan1,8,
Peter G. Alexander1,7,
Hang Lin1,2,7
1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine,
2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering,
3Department of Neurobiology, University of Pittsburgh School of Medicine,
4Department of Orthopaedic Surgery, Stanford University,
5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center,
6Department of Bioengineering, Stanford University,
7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine,
8, The Chinese University of Hong Kong
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