efficient-differentiation-mouse-embryonic-stem-cells-into-motor

Efficient Differentiation of Mouse Embryonic Stem Cells into Motor Neurons

Direct differentiation of embryonic stem (ES) cells into functional  motor neurons represents a promising resource to study disease mechanisms, to  screen ...

Alfred I. duPont Hospital for Children

Constitutive phosphoinositide 3-kinase (PI3K)/Akt activation is common in T cell acute lymphoblastic leukemia (T-ALL). Although four distinct class I PI3K isoforms (α, β, γ, δ) could participate in T-ALL pathogenesis, none has been implicated in this process. We report that in the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors. These results support combined inhibition of PI3Kγ/δ as therapy for T-ALL.

Dosh Whye

Nemours Biomedical Research

Alfred I. duPont Hospital for Children

Efficient Differentiation of Mouse Embryonic Stem Cells into Motor Neurons

Dosh Whye

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Alfred I. duPont Hospital for Children

Efficient Differentiation of Mouse Embryonic Stem Cells into Motor Neurons

Nemours Biomedical Research