Dirk Grimm

Primary human cells differ in their susceptibility to rAAV-2-mediated gene transfer and duration of reporter gene expression.

Production methods for gene transfer vectors based on adeno-associated virus serotypes.

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6.

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy.

Adeno-associated virus vectors for short hairpin RNA expression.

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype.

Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors.

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.

The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9.

A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8.

Combinatorial RNAi: a winning strategy for the race against evolving targets?

Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium.

RNAi and gene therapy: a mutual attraction.

Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells.

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia.

Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic.

Small silencing RNAs: state-of-the-art.

Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice.

Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems.

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver.

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes.

Cellular RNA interference mechanisms. Preface.

When cellular networks run out of control: global dysregulation of the RNAi machinery in human pathology and therapy.

To go, or not to go, that is the question - six personal reflections on how geographic mobility may affect your career and life.

The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression.

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.

Expression determinants of mammalian argonaute proteins in mediating gene silencing.

AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining.

Death receptor-based enrichment of Cas9-expressing cells.

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus.

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

Next-generation AAV vectors for clinical use: an ever-accelerating race.

Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution.

Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology.

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.

Impact of the Assembly-Activating Protein on Molecular Evolution of Synthetic Adeno-Associated Virus Capsids.

AAVvector-mediated in vivo reprogramming into pluripotency.

Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9.

A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses.

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses.

Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors.

Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins.

Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome.

Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors.

Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template.

Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.

Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity.

Computational design of anti-CRISPR proteins with improved inhibition potency.

Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements.

Production, Processing, and Characterization of Synthetic AAV Gene Therapy Vectors.

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants.

Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders.

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein.

'Hit and run' therapy averts macular degeneration.

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting.

Characterization of the GBoV1 Capsid and Its Antibody Interactions.

Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses.

A Versatile In Vivo System to Study Myc in Cell Reprogramming.

Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR-Cas gene editing.

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.

Neutralizing Antibody Evasion and Transduction with Purified Extracellular Vesicle-Enveloped Adeno-Associated Virus Vectors.

An RNA Interference/Adeno-Associated Virus Vector-Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus.

Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8.

Adeno-Associated Viruses (AAV) and Host Immunity - A Race Between the Hare and the Hedgehog.

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors.

Natural killer cells act as an extrinsic barrier for in vivo reprogramming.

Right on target: The next class of efficient, safe, and specific RNAi triggers.

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening.

Intranasal application of adeno-associated viruses: a systematic review.

Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning.

Boosters for adeno-associated virus vector (AAV) (r)evolution.

In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice.

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.

Determination of AAV properties by single amino acids: Go(o)d is in the details.