Ian Mohr

Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.

Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.

Identification of a lytic-cycle Epstein-Barr virus gene product that can regulate PKR activation.

Translation initiation and viral tricks.

In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.

Genetic metamorphosis of herpes simplex virus-1 into a biological therapeutic for human cancer.

Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides.

Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.

Neutralizing innate host defenses to control viral translation in HSV-1 infected cells.

Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells.

Full resistance of herpes simplex virus type 1-infected primary human cells to alpha interferon requires both the Us11 and gamma(1)34.5 gene products.

Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells.

To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control.

Phosphorylation and dephosphorylation events that regulate viral mRNA translation.

Assembly of an active translation initiation factor complex by a viral protein.

Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions.

Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.

Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor.

Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.

Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.

Activation of host translational control pathways by a viral developmental switch.

Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons.

Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells.

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.

A herpesvirus kinase that masquerades as Akt: you don't have to look like Akt, to act like it.

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.

Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation.

Viral subversion of the host protein synthesis machinery.

Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promoters.

A cell culture model of facial palsy resulting from reactivation of latent herpes simplex type 1.

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies.

Transient Reversal of Episome Silencing Precedes VP16-Dependent Transcription during Reactivation of Latent HSV-1 in Neurons.

Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells.