Luke C. Davies

Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells.

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation.

Macrophage heterogeneity and acute inflammation.

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

Tissue-resident macrophages.

miR-192 induces G2/M growth arrest in aristolochic acid nephropathy.

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation.

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production.

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors.

Diversity and environmental adaptation of phagocytic cell metabolism.

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors.

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway.

Innate immunology in COVID-19-a living review. Part I: viral entry, sensing and evasion.

Innate immunology in COVID-19-a living review. Part II: dysregulated inflammation drives immunopathology.

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.

mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health - a prospective observational cohort study protocol.

Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis.

Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study.

nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study.