Jianqing Xu

HIV-1/AIDS vaccine development: are we in the darkness.

HCV coinfection associated with slower disease progression in HIV-infected former plasma donors naïve to ART.

Deglycosylation of HIV-1 AE Gp140 enhances the capacity to elicit neutralizing antibodies against the heterologous HIV-1 clade.

Transcriptional analysis of immune-related genes in dendritic cells from hepatitis B surface antigen (HBsAg)-positive transgenic mice and regulation of Fc gamma receptor IIB by HBsAg-anti-HBs complex.

Transmission of new CRF07_BC strains with 7 amino acid deletion in Gag p6.

A new approach for sequencing virion genome of Chinese HIV-1 strains subtype B and BC from plasma.

[Establishment of human colorectal tissue model in HIV-1 mucosal infection].

Early adaptive humoral immune responses and virus clearance in humans recently infected with pandemic 2009 H1N1 influenza virus.

Near full-length sequence analysis of two new HIV type 1 unique (CRF01_AE/B) recombinant forms among men who have sex with men in China.

Chloramphenicol improved expression of recombinant cholera toxin B subunit in Escherichia coli and its adjuvanticity.

Boosting heterosubtypic neutralization antibodies in recipients of 2009 pandemic H1N1 influenza vaccine.

Establishing a Th17 based mouse model for preclinical assessment of the toxicity of candidate microbicides.

HIV/AIDS vaccine development: are we walking out from the dark?

Efficacy, stability, and biosafety of sifuvirtide gel as a microbicide candidate against HIV-1.

Minocycline down-regulates topical mucosal inflammation during the application of microbicide candidates.

Five new CRF07_BC near full-length sequences isolated from Sichuan, China.

In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus.

Immunization with HBsAg-Fc fusion protein induces a predominant production of Th1 cytokines and reduces HBsAg level in transgenic mice.

Development of skewed functionality of HIV-1-specific cytotoxic CD8(+) T cells from primary to early chronic phase of HIV infection.

Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice.

The average IFN-γ secreting capacity of specific CD8(+) T cells is compromised while increasing copies of a single T cell epitope encoded by DNA vaccine.

A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade.

New emerging recombinant HIV-1 strains and close transmission linkage of HIV-1 strains in the Chinese MSM population indicate a new epidemic risk.

Identification of dominant antibody-dependent cell-mediated cytotoxicity epitopes on the hemagglutinin antigen of pandemic H1N1 influenza virus.

Potent T cell responses induced by single DNA vaccine boosted with recombinant vaccinia vaccine.

Serological investigation of subclinical influenza A(H7H9) infection among healthcare and non-healthcare workers in Zhejiang Province, China.

PA-356R is a unique signature of the avian influenza A (H7N9) viruses with bird-to-human transmissibility: potential implication for animal surveillances.

Safe pseudovirus-based assay for neutralization antibodies against influenza A(H7N9) virus.

The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development.

MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells.

Multiple independent introductions of HIV-1 CRF01_AE identified in China: what are the implications for prevention?

Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection.

[HIV-1 infection up-regulating expression of interferon-stimulated gene 15 in cell lines].

Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission.

Epidemiologic report and serologic findings for household contacts of three cases of influenza A (H7N9) virus infection.

Differential compartmentalization of HIV-targeting immune cells in inner and outer foreskin tissue.

Boosting functional avidity of CD8+ T cells by vaccinia virus vaccination depends on intrinsic T-cell MyD88 expression but not the inflammatory milieu.

CTL responses to HSP47 associated with the prolonged survival of patients with glioblastomas.

As a genetic adjuvant, CTA improves the immunogenicity of DNA vaccines in an ADP-ribosyltransferase activity- and IL-6-dependent manner.

Fusion-expressed CTB improves both systemic and mucosal T-cell responses elicited by an intranasal DNA priming/intramuscular recombinant vaccinia boosting regimen.

Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma.

Virus-host mucosal interactions during early SIV rectal transmission.

Transgenic 4-1BBL-engineered vaccine stimulates potent Gag-specific therapeutic and long-term immunity via increased priming of CD44(+)CD62L(high) IL-7R(+) CTLs with up- and downregulation of anti- and pro-apoptosis genes.

IFN-stimulated gene LY6E in monocytes regulates the CD14/TLR4 pathway but inadequately restrains the hyperactivation of monocytes during chronic HIV-1 infection.

Willingness to participate in HIV therapeutic vaccine trials among HIV-infected patients on ART in China.

Hepatitis B virus and hepatitis C virus infection among HIV-1-infected injection drug users in Dali, China: prevalence and infection status in a cross-sectional study.

The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects.

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells.

[HIV/AIDS related mortality in southern Shanxi province and its risk factors].

Identification of Non-HIV Immunogens That Bind to Germline b12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies.

Recruitment of HIV-1 target cells at topical mucosal sites: a sensitive and early marker for determining the safety of microbicide candidates.

Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitution.

Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival.

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.

Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China.

Short Communication: The Distribution of Potential N-Linked Glycosylation Sites in Gp120 Differs Among Major HIV-1 Subtypes Circulating in China.

Mucosal Topical Microbicide Candidates Exert Influence on the Subsequent SIV Infection and Survival by Regulating SIV-Specific T-Cell Immune Responses.

Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues.

Successive site translocating inoculation potentiates DNA/recombinant vaccinia vaccination.

Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway.

Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide.

Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection.

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation.

Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients.

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks.

Sequential immunization with consensus influenza hemagglutinins raises cross-reactive neutralizing antibodies against various heterologous HA strains.

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.

Characterization of founder viruses in very early SIV rectal transmission.

On the Role of CD8 T Cells in Determining Recovery Time from Influenza Virus Infection.

Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency.

CD40 agonist converting CTL exhaustion via the activation of the mTORC1 pathway enhances PD-1 antagonist action in rescuing exhausted CTLs in chronic infection.

Immune Signature of Enhanced Functional Avidity CD8 T Cells in vivo Induced by Vaccinia Vectored Vaccine.

Expression, purification, and renaturation of a recombinant peptide-based HIV vaccine in Escherichia coli.

Clinically relevant circulating microRNA profiling studies in pancreatic cancer using meta-analysis.

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

Identification of miRNA-mRNA crosstalk in CD4 T cells during HIV-1 infection by integrating transcriptome analyses.

MicroRNA miR-126-5p Enhances the Inflammatory Responses of Monocytes to Lipopolysaccharide Stimulation by Suppressing Cylindromatosis in Chronic HIV-1 Infection.

Sendai Virus Mucosal Vaccination Establishes Lung-Resident Memory CD8 T Cell Immunity and Boosts BCG-Primed Protection against TB in Mice.

Induction of Broadly Cross-Reactive Stalk-Specific Antibody Responses to Influenza Group 1 and Group 2 Hemagglutinins by Natural H7N9 Virus Infection in Humans.

Both haemagglutinin-specific antibody and T cell responses induced by a chimpanzee adenoviral vaccine confer protection against influenza H7N9 viral challenge.

A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins.

Fc functional antibodies in humans with severe H7N9 and seasonal influenza.

Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects.

Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui.

Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection.

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency.

The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.

Molecular analyses of prostate tumors for diagnosis of malignancy on fine-needle aspiration biopsies.

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection.

Erratum to: Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection.

Responses to emerging and re-emerging infectious diseases: One world, One health.

AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling.

Clonally diverse CD38HLA-DRCD8 T cells persist during fatal H7N9 disease.

Toward universal influenza virus vaccines: from natural infection to vaccination strategy.

CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens.

Single-Cell Approach to Influenza-Specific CD8 T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection.

TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway.

Molecular Changes of Lung Malignancy in HIV Infection.

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells.

Pharmacologic ascorbate as a pro-drug for hydrogen peroxide release to kill mycobacteria.

Determination of neutralization activities by a new versatile assay using an HIV-1 genome carrying the Gaussia luciferase gene.

Influenza Vaccine With Consensus Internal Antigens as Immunogens Provides Cross-Group Protection Against Influenza A Viruses.

Hepatomas are exquisitely sensitive to pharmacologic ascorbate (P-AscH).

CD8α conventional dendritic cells control Vβ T-cell immunity in response to Staphylococcus aureus infection in mice.

Induction of cross-neutralizing antibodies by sequential immunization with heterologous papillomavirus L1VLPs and its implications for HPV prophylactic vaccines.

Identification of Specific Long Non-Coding Ribonucleic Acid Signatures and Regulatory Networks in Prostate Cancer in Fine-Needle Aspiration Biopsies.

The immunologic dominance of an epitope within a rationally designed poly-epitope vaccine is influenced by multiple factors.

Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy.

Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition).

Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus.

Clinical and CT features of early stage patients with COVID-19: a retrospective analysis of imported cases in Shanghai, China.

Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors.

IFN-κ suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis.

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies.

A benchmark dataset of protein antigens for antigenicity measurement.

Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection.

Freeze-Drying Formulations Increased the Adenovirus and Poxvirus Vaccine Storage Times and Antigen Stabilities.

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor.

Correction to: Identification of miRNA-mRNA crosstalk in CD4 T cells during HIV-1 infection by integrating transcriptome analyses.

Internal Gene Cassette From a Human-Origin H7N9 Influenza Virus Promotes the Pathogenicity of H9N2 Avian Influenza Virus in Mice.

A clinical pilot study on the safety and efficacy of aerosol inhalation treatment of IFN-κ plus TFF2 in patients with moderate COVID-19.

Mathematical models for devising the optimal SARS-CoV-2 strategy for eradication in China, South Korea, and Italy.

Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza Viruses.

PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling.

Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP.

An open-label, randomized trial of the combination of IFN-κ plus TFF2 with standard care in the treatment of patients with moderate COVID-19.

From Monovalent to Multivalent Vaccines, the Exploration for Potential Preventive Strategies Against Hand, Foot, and Mouth Disease (HFMD).

CD160 Plays a Protective Role During Chronic Infection by Enhancing Both Functionalities and Proliferative Capacity of CD8+ T Cells.

A Systemic Prime-Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection.

One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device.

Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Current status and future development of anti-HIV chimeric antigen receptor T-cell therapy.

Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing.

PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo.

IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy.

CagA Interacts with SHP-1 to Suppress the Immune Response by Targeting TRAF6 for K63-Linked Ubiquitination.

Vaccinia virus-based vector against infectious diseases and tumors.

Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates.

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients.

Monitoring Coronavirus Disease 2019: A Review of Available Diagnostic Tools.

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat.

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge.

High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis.

Expansion of Human iNKT Cells Ex Vivo.

Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy.

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants.

Development of recombinant COVID-19 vaccine based on CHO-produced, prefusion spike trimer and alum/CpG adjuvants.

Influenza A Virus-Host Specificity: An Ongoing Cross-Talk Between Viral and Host Factors.

Hsa-miR-31 Governs T-Cell Homeostasis in HIV Protection IFN-γ-Stat1-T-Bet Axis.

HIV-1 Vif suppresses antiviral immunity by targeting STING.

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells.

The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4 T cells by preventing ferroptosis.

Implications of the accumulation of CXCR5 NK cells in lymph nodes of HIV-1 infected patients.

Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral .

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity.

SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network.

Prompt Antiviral Action of Pulmonary CD8+ T Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung.

Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression.

Author Correction: Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.

Feasibility of iNKT cell and PD-1+CD8+ T cell-based immunotherapy in patients with lung adenocarcinoma: Preliminary results of a phase I/II clinical trial.

Pathologically complete remission to combination of invariant NK T cells and anti-CD20 antibody in a refractory HIV+ diffuse large B-cell lymphoma patient.

Recombinant programmed cell death protein 1 functions as an immune check point blockade and enhances anti-cancer immunity.

Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2.

Comprehensive RNA-seq reveals molecular changes in kidney malignancy among people living with HIV.

Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway.

Shows Unique Patterns of Codon Usage Bias in Conventional Versus Unconventional Clade.

Rapid generation of a mouse model for evaluating on-target normal tissue toxicity of human CAR-T cells using replication-defective recombinant adenovirus.

Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection.

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines.

Revealing the characteristics of ZIKV infection through tissue-specific transcriptome sequencing analysis.

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation.

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum.

Improving the expansion of human tumor-reactive CD8 + T cells by targeting toll-like receptors.

Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells.

A randomized, double-blind, placebo-controlled phase I trial of inhalation treatment of recombinant TFF2-IFN protein: A multifunctional candidate for the treatment of COVID-19.

NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-β/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer.

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env cells invivo.

The development and characterization of a stable Coxsackievirus A16 infectious clone with Nanoluc reporter gene.

SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway.

A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice.

Corrigendum: A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice.

Adipose-derived stem cells show hepatic differentiation potential and therapeutic effect in rats with acute liver failure.

Induced regulatory T cells modified by knocking down T-bet in combination with ectopic expression of inhibitory cytokines effectively protect graft-versus-host disease.

Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING.

A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response.

Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1CD8 T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer.

Exosomal lncRNA LINC01268 promotes pancreatic cancer progression via the miR-217-KIF2A-PI3K/AKT axis.

Innate Immune Response in Respiratory System: A Double-edged Sword Against Virus Infection.

The Arms Race in the War Between Virus and Host: Implications for Anti-Infection Immunity.

Scopoletin Reactivates Latent HIV-1 by Inducing NF-κB Expression without Global T Cell Activation.

Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung.

CD160 Signaling Is Essential for CD8+ T Cell Memory Formation via Upregulation of 4-1BB.

Broad-spectrum vaccine via combined immunization routes triggers potent immunity to SARS-CoV-2 and its variants.

adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4.

A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China.

A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses.

One HA stalk topping multiple heads as a novel influenza vaccine.

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes.

BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4 T-cell exhaustion.

PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.

Construction of an infectious clone for enterovirus A89 and mutagenesis analysis of viral infection and cell binding.

Integration of HiBiT into enteroviruses: A universal tool for advancing enterovirus virology research.

An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza.

Integrated single-cell transcriptome and T cell receptor profiling reveals defects of T cell exhaustion in pulmonary tuberculosis.

Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection-an integrated account of virus pathogenicity and vaccination effectiveness.

Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study.

A fusion protein approach to integrate antiviral and anti-inflammatory activities for developing new therapeutics against influenza A virus infection.