Vincent Poitout

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity.

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase.

Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol.

Insulin secretory deficiency and glucose intolerance in Rab3A null mice.

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.

The ins and outs of fatty acids on the pancreatic beta cell.

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.

A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.

Beta-cell lipotoxicity: burning fat into heat?

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion.

Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element.

The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.

Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

Regulation of the insulin gene by glucose and fatty acids.

Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS.

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

G protein-coupled receptors and insulin secretion: 119 and counting.

Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube.

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

Glucolipotoxicity of the pancreatic beta-cell: myth or reality?

The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation.

Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.

GPR40: good cop, bad cop?

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.

Glucolipotoxicity of the pancreatic beta cell.

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.

Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress.

Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity.

Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1.

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.

Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.

The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.

Pioglitazone acutely reduces energy metabolism and insulin secretion in rats.

Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents.

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells.

Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3 Beta in Pancreatic Beta Cells.