Richard Francis

Endothelin receptor A blockade ameliorates hypothermic ischemia-reperfusion-related microhemodynamic disturbances during liver transplantation in the rat.

p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development.

Evaluation and management of scoliosis.

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis.

Shared scheme for assessing drugs for multiple sclerosis: cost effective provision of effective treatments for multiple sclerosis.

Separation of immunoglobulin G precipitate from contaminating proteins using microfiltration.

Optimised affinity purification of polyclonal antibodies from hyper immunised ovine serum using a synthetic Protein A adsorbent, MAbsorbent A2P.

Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.

Optimal conditions for the papain digestion of polyclonal ovine IgG for the production of bio-therapeutic Fab fragments.

Application of a decision-support tool to assess pooling strategies in perfusion culture processes under uncertainty.

From genome to vaccines for leishmaniasis: screening 100 novel vaccine candidates against murine Leishmania major infection.

It's a puzzle all right: the hippocampus and food hoarding.

The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells.

Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation.

Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells.

The integrated simulation and assessment of the impacts of process change in biotherapeutic antibody production.

Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells.

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements.

Detection and quantification of affinity ligand leaching and specific antibody fragment concentration within chromatographic fractions using surface plasmon resonance.

Decision-support software for the industrial-scale chromatographic purification of antibodies.

A prototype software methodology for the rapid evaluation of biomanufacturing process options.

Evolution of differences in transport function in Slc11a family members.

Evaluation of a novel agarose-based synthetic ligand adsorbent for the recovery of antibodies from ovine serum.

Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia.

Mouse model of heterotaxy with single ventricle spectrum of cardiac anomalies.

The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells.

Global Sensitivity Analysis for the determination of parameter importance in bio-manufacturing processes.

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells.

The d subunit plays a central role in human vacuolar H(+)-ATPases.

Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport.

Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy.

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer.

Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway.

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.

Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development.

Ventricular rotation is independent of cardiac looping: a study in mice with situs inversus totalis using speckle-tracking echocardiography.

Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.

A screen for endocytic motifs.

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.

Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia.

An automated packed protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum.

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.

Classification and regression tree and spatial analyses reveal geographic heterogeneity in genome wide linkage study of Indian visceral leishmaniasis.

Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule.

Comparison of post-treatment effects of conventional and acupuncture-like transcutaneous electrical nerve stimulation (TENS): A randomised placebo-controlled study using cold-induced pain and healthy human participants.

Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.

Conventional versus acupuncture-like transcutaneous electrical nerve stimulation on cold-induced pain in healthy human participants: effects during stimulation.

Comparison of post-treatment effects of conventional and acupuncture-like transcutaneous electrical nerve stimulation (TENS): A randomised placebo-controlled study using cold-induced pain and healthy human participants.

Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.

Connexin43 modulates cell polarity and directional cell migration by regulating microtubule dynamics.

Traumatic intracerebral hemorrhage--to operate or not?

Congenital heart disease and the specification of left-right asymmetry.

Rapid detection of Klebsiella pneumoniae carbapenemase genes in enterobacteriaceae directly from blood culture bottles by real-time PCR.

The characteristics of acupuncture-like transcutaneous electrical nerve stimulation (acupuncture-like TENS): a literature review.

West Nile virus infection in blood donors in the New York City area during the 2010 seasonal epidemic.

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service.

FusionFinder: a software tool to identify expressed gene fusion candidates from RNA-Seq data.

TENS (transcutaneous electrical nerve stimulation) for labour pain.

Acquired hemoglobin variants and exposure to glucose-6-phosphate dehydrogenase deficient red blood cell units during exchange transfusion for sickle cell disease in a patient requiring antigen-matched blood.

Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population.

The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.

The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and Trends.

Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model.

Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice.

ARMC4 Mutations Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry.

The ability of an arginine to tryptophan substitution in Saccharomyces cerevisiae tRNA nucleotidyltransferase to alleviate a temperature-sensitive phenotype suggests a role for motif C in active site organization.

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Increased postoperative respiratory complications in heterotaxy congenital heart disease patients with respiratory ciliary dysfunction.

Imaging techniques for visualizing and phenotyping congenital heart defects in murine models.

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

Ion Torrent sequencing for conducting genome-wide scans for mutation mapping analysis.

Interrogating congenital heart defects with noninvasive fetal echocardiography in a mouse forward genetic screen.

Attitudes to intracranial pressure monitoring of traumatic intracerebral haemorrhage.

Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3.

GOLink: Finding Cooccurring Terms across Gene Ontology Namespaces.

A comparison of adverse reaction rates for PAS C versus plasma platelet units.

Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice.

Decellularized tracheal extracellular matrix supports epithelial migration, differentiation, and function.

Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model.

Methaemoglobinaemia and haemolysis following pegloticase infusion for refractory gout in a patient with a falsely negative glucose-6-phosphate dehydrogenase deficiency result.

DataSHIELD: taking the analysis to the data, not the data to the analysis.

Marine geophysics. New global marine gravity model from CryoSat-2 and Jason-1 reveals buried tectonic structure.

Airway ciliary dysfunction and sinopulmonary symptoms in patients with congenital heart disease.

The effects of temperature and anesthetic agents on ciliary function in murine respiratory epithelia.

IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.

Dexmedetomidine and fentanyl exhibit temperature dependent effects on human respiratory cilia.

Early Surgery versus Initial Conservative Treatment in Patients with Traumatic Intracerebral Hemorrhage (STITCH[Trauma]): The First Randomized Trial.

First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes.

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.

Distribution of raphespinal fibers in the mouse spinal cord.

Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children.

G6PD Deficiency in an HIV Clinic Setting in the Dominican Republic.

Automated identification of abnormal respiratory ciliary motion in nasal biopsies.

Surgical Trial In Traumatic intraCerebral Haemorrhage (STITCH): a randomised controlled trial of Early Surgery compared with Initial Conservative Treatment.

Characteristics of traumatic intracerebral haemorrhage: An assessment of screening logs from the STITCH(Trauma) Trial.

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.

ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data.

DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia.

Reference genotype and exome data from an Australian Aboriginal population for health-based research.

Diagnosis of a rare fetal haemoglobinopathy in the age of next-generation sequencing.

Attitudes in 2013 to Monitoring Intracranial Pressure for Traumatic Intracerebral Haemorrhage.

Red blood cell components: Meeting the quantitative and qualitative transfusion needs.