Nadya Tarasova

Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase.

Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice.

Mutational analysis of ABCG2: role of the GXXXG motif.

Small molecule toxins targeting tumor receptors.

Transmembrane inhibitors of P-glycoprotein, an ABC transporter.

In memoriam: Christopher J. Michejda (December 19, 1937-January 9, 2007).

Synthesis and biological activity of 5-aza-ellipticine derivatives.

Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth.

Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502).

Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target.

Bombesin marine toxin conjugates inhibit the growth of lung cancer cells.

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

STAT1 activation regulates proliferation and differentiation of renal progenitors.

Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.

Peptide structure stabilization by membrane anchoring and its general applicability to the development of potent cell-permeable inhibitors.

Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.

The structure of monomeric components of self-assembling CXCR4 antagonists determines the architecture of resulting nanostructures.

Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain.