Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical CareM. Atif Yaqub *1, Marta Zanoletti *1, Lorenzo Cortese 1, Daniel Senciales Sánchez 1, Caterina Amendola 2, Lorenzo Frabasile 2, Umut Karadeniz 1, Jacqueline Martinez Garcia 1, Marta Martin 1, Jordi Cortes-Picas 1, Alba Caballer 3, Edgar Cortes 3, Sara Nogales 3, Alberto Tosi 4, Talyta Carteano 5, Diego Sanoja Garcia 5, Jakub Tomanik 6, Tessa Wagenaar 6, Hsiao Mui 6, Claudia Nunzia Guadagno 7, Shahrzad Parsa 8, Sanathana Konugolu Venkata Sekar 7, Luc Demarteau 6, Tijl Houtbeckers 6, Udo M. Weigel 8, Michele Lacerenza 9, Mauro Buttafava 9, Alessandro Torricelli 2,10, Davide Contini 2, Jaume Mesquida 3, Turgut Durduran 1,11
1ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 2Dipartimento di Fisica, Politecnico di Milano, 3Critical Care Department, Parc Taulí Hospital Universitari, 4Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, 5ASPHALION s.l., 6Splendo, 7BioPixS-Biophotonics Standards, IPIC, Tyndall National Institute, 8Hemophotonics s.l., 9PIONIRS s.r.l., 10Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, 11Institució Catalana de Recerca i Estudis Avançats (ICREA)
We describe a protocol to non-invasively and continuously measure absolute microvascular blood flow index and blood oxygen saturation using a multi-modal device based on near-infrared diffuse optics. We then evaluate the metabolic rate of oxygen consumption and reactive hyperemia utilizing a vascular occlusion test.
