A Modified Technique for Inducing Polycystic Ovary Syndrome in MiceBokang Zhou *1, Fei Guo *1, Yuhang Long 1, Junsen She 2,3, Ling Gao 1,2,4,5, Hefeng Huang 1,2,3,4,5
1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, 2Women's Hospital, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, 3International Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, 4Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences (No. 2019RU056), 5State Key Laboratory of Cardiology
This protocol introduces a technique for inducing polycystic ovary syndrome (PCOS) models in mice through controlled letrozole release using mini-pumps. Under adequate anesthesia, the mini-pump was implanted subcutaneously, and PCOS was successfully induced in the mice after a certain period of the mini-pump release.
