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British American Tobacco

1 ARTICLES PUBLISHED IN JoVE

Biochemistry

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Andrew Baxter¹, Emmanuel Minet¹

¹Research and Development, British American Tobacco

Metabolic competency of in vitro systems is a key requirement for the biotransformation and disposition of drugs and toxicants. In this protocol, we describe the application of reference metabolic probes to assess phase I metabolism in cell cultures.