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Charlie Norwood Va Medical Center

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Mary Zimmerman^*1, Xiaolin Hu^*1, Kebin Liu¹

¹Department of Biochemistry and Molecular Biology, Medical College of Georgia

An experimental lung metastasis and CTL immunotherapy mouse model for analysis of tumor cells-T cell interaction in vivo.

Medicine

An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis

Amy V. Paschall^1,2,3, Kebin Liu^1,2,3

¹Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, ²Georgia Cancer Center, Augusta University, ³Charlie Norwood VA Medical Center

An orthotopic breast cancer primary tumor model and surgical removal of primary tumor to extend mouse life to generate spontaneous metastasis are described. The tumor growth and progression are monitored and quantified by luciferase fluorescence imaging.