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Obihiro University of Agriculture and Veterinary Medicine

2 ARTICLES PUBLISHED IN JoVE

Behavior

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Tatsuhiko Goto^1,2, Atsushi Toyoda^1,2,3

¹College of Agriculture, Ibaraki University, ²Cooperation between Agriculture and Medical Science, Ibaraki University, ³United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology

Here, methods for developing a mouse model of subchronic and mild social defeat stress are described and used to investigate the pathogenic features of depression including hyperphagia- and polydipsia-like symptoms following increased body weight.

Behavior

Measuring Active and Passive Tameness Separately in Mice

Hiromichi Nagayama^1,2, Yuki Matsumoto^1,2, Akira Tanave¹, Motoko Nihei¹, Tatsuhiko Goto³, Tsuyoshi Koide^1,2

¹Mouse Genomics Resource Laboratory, National Institute of Genetics, ²Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), ³Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine

Tameness in animals includes a reduction of avoidance responses to humans (passive tameness) and an increase in active approaches to humans (active tameness). Here, we describe detailed protocols for three behavioral tests (active tameness, passive tameness, and stay-on-hand tests) to separately measure the active and passive tameness of mice.