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University Hospital of Rennes

2 ARTICLES PUBLISHED IN JoVE

Medicine

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Pierre-Emmanuel Noly¹, Julien Guihaire^1,4, Matthieu Coblence¹, Peter Dorfmüller^2,5, Elie Fadel^1,3, Olaf Mercier^1,3

¹Surgical Research Lab, Marie Lannelongue Hospital, ²Department of Pathology, Marie Lannelongue Hospital, ³Department of Thoracic and Vascular Surgery, Marie Lannelongue Hospital, ⁴Thoracic and Cardiovascular Surgery, University Hospital of Rennes, ⁵INSERM U999 Paris-Sud University

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.

Medicine

Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography

Simon Dang Van^1,2,3, Dorothée Brunet^1,2,3, Ali Akamkam^1,2,3, Benoit Decante^1,2, Julien Guihaire^1,2,3

¹Laboratory of Preclinical Research, Department of Research and Innovation, Groupe Hospitalier Paris Saint Joseph, ²Inserm UMR S 999, Pulmonary Hypertension: Pathophysiology and Novel Therapies, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, ³Department of Cardiac Surgery, Marie Lannelongue Hospital

A reliable noninvasive approach for functional assessment of the donor heart during normothermic ex situ heart perfusion (NESP) is lacking. We herein describe a protocol for ex situ assessment of myocardial performance using the epicardial echocardiography and conductance catheter method.