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University of Wisconsin at Milwaukee

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Marie Vandecasteele^1,2, S. M.¹, Sébastien Royer^1,3, Mariano Belluscio¹, Antal Berényi¹, Kamran Diba^1,4, Shigeyoshi Fujisawa¹, Andres Grosmark¹, Dun Mao¹, Kenji Mizuseki¹, Jagdish Patel¹, Eran Stark¹, David Sullivan¹, Brendon Watson¹, György Buzsáki¹

¹Center for Molecular and Behavioral Neuroscience, University of New Jersey, ²Center for Interdisciplinary Research in Biology, Collège de France, ³Janelia Farm Research Campus, Howards Hughes Medical Institute, ⁴Deptartment of Psychology, University of Wisconsin at Milwaukee

We describe methods for large-scale recording of multiple single units and local field potential in behaving rodents with silicon probes. Drive fabrication, probe attachment to the drive and probe implantation processes are illustrated in sufficient details for easy replication.