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STEMO-Consortium

3 ARTICLES PUBLISHED IN JoVE

Medicine

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Lukas Julius Speetzen¹, Matthias Endres¹, Alexander Kunz¹

¹Department of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany

There is accumulating evidence, that ischemic preconditioning (PC) – a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We established bilateral common carotid artery occlusion (BCCAO) as a preconditioning stimulus to induce early ischemic tolerance (IT) to transient focal cerebral ischemia (induced by middle cerebral artery occlusion, MCAO) in C57Bl6/J mice.

Medicine

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Johanna Hamel^1,2, Antje Kraft¹, Sven Ohl³, Sophie De Beukelaer¹, Heinrich J. Audebert^1,2, Stephan A. Brandt¹

¹Department of Neurology, Universitätsmedizin Charité, ²Center for Stroke Research Berlin (CSB), Universitätsmedizin Charité, ³Berlin School of Mind and Brain, Humboldt Universität zu Berlin

Patients with visual deficits after stroke report about different constraints in daily life most likely due to variable compensatory strategies, which are difficult to differentiate in clinical routine. We present a clinical set-up which allows measurement of different compensatory head- and eye-movement-strategies and evaluating their effects on driving performance.

Medicine

Prehospital Thrombolysis: A Manual from Berlin

Martin Ebinger^1,2,5, Sascha Lindenlaub^1,3,5, Alexander Kunz^1,2,5, Michal Rozanski^2,5, Carolin Waldschmidt^2,5, Joachim E. Weber^2,5, Matthias Wendt^2,5, Benjamin Winter^1,2,5, Philipp A. Kellner^4,5, Sabina Kaczmarek^4,5, Matthias Endres^1,2,5, Heinrich J. Audebert^1,2,5

¹Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, ²Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, ³Medical School of the Universität Hamburg, Universitätsklinikum Hamburg - Eppendorf, ⁴Berliner Feuerwehr, ⁵STEMO-Consortium

Identification of suspected stroke in the dispatch center of the Berlin Fire Brigade prompts the deployment of a CT-equipped ambulance. If ischemic stroke is confirmed and contraindications are excluded prehospital thrombolysis is applied.