Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer ApproachTheresa L. M. Pohl 1, Elisabeth H. Schwab 1, Elisabetta A. Cavalcanti-Adam 1,2
1Department of Biophysical Chemistry, Institute for Physical Chemistry, University of Heidelberg, 2Max Planck Institute for Intelligent Systems at Stuttgart
We describe a method for accomplishing efficient immobilization of BMP-2 on surfaces. Our approach is based on the formation of a self-assembled monolayer to achieve the covalent binding of BMP-2 via its free amine residues. This method is a useful tool to study signaling at the cell membrane.
