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Bruker Preclinical Imaging

2 ARTICLES PUBLISHED IN JoVE

Medicine

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Todd A. Sasser¹, Sarah E. Chapman², Shengting Li¹, Caroline Hudson², Sean P. Orton¹, Justin M. Diener³, Seth T. Gammon¹, Carlos Correcher⁴, W. Matthew Leevy²

¹Carestream Molecular Imaging , ²Department of Chemistry and Biochemistry, University of Notre Dame , ³Freimann Life Science Center, University of Notre Dame , ⁴Research and Development, Oncovision, GEM-Imaging S.A.

Fat content analysis is routinely conducted in studies utilizing murine obesity models. Emerging methods in small animal CT imaging and analysis are providing for longitudinal detail rich fat content analysis. Here we detail step by step procedures for performing small animal CT imaging, analysis, and visualization.

Medicine

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Natalia J. Sumi¹, Eydis Lima¹, John Pizzonia², Sean P. Orton³, Vinicius Craveiro¹, Wonduk Joo¹, Jennie C. Holmberg¹, Marta Gurrea¹, Yang Yang-Hartwich¹, Ayesha Alvero¹, Gil Mor¹

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, ²NatureMost Laboratories, ³Bruker Preclinical Imaging

We describe a non-invasive animal imaging platform that allows the detection, quantification, and monitoring of ovarian cancer growth and recurrence. This intra-peritoneal xenograft model mimics the clinical profile of patients with ovarian cancer.