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Klinikum rechts der Isar der TU München

2 ARTICLES PUBLISHED IN JoVE

Medicine

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Jennifer Altomonte¹, Kim A. Muñoz-Álvarez², Katsunori Shinozaki³, Christine Baumgartner⁴, Georgios Kaissis⁵, Rickmer Braren⁵, Oliver Ebert¹

¹II. Medizinische Klinik, Klinikum rechts der Isar der TU München, ²Department of Nuclear Medicine, Klinikum rechts der Isar der TU München, ³Division of Clinical Oncology, Hiroshima Prefectural Hospital, ⁴Center for Preclinical Research, Klinikum rechts der Isar der TU München, ⁵Institute for Diagnostic and Interventional Radiology, Klinikum rechts der Isar der TU München

Oncolytic virotherapies are under development as novel therapeutics for the treatment of hepatocellular carcinoma (HCC). Here we describe a method for locoregional therapy of HCC via hepatic arterial administration of oncolytic virus.

Cancer Research

Hyperpolarized ¹³C Metabolic Magnetic Resonance Spectroscopy and Imaging

Eugen Kubala^*1,2,3, Kim A. Muñoz-Álvarez^*1, Geoffrey Topping¹, Christian Hundshammer^1,2, Benedikt Feuerecker¹, Pedro A. Gómez^3,4, Giorgio Pariani^1,5,6, Franz Schilling¹, Steffen J. Glaser², Rolf F. Schulte³, Marion I. Menzel³, Markus Schwaiger¹

¹Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, ²Department of Chemistry, Technische Universität München, ³GE Global Research, ⁴Zentralinstitut für Medizintechnik der Technischen Universität München (IMETUM), Technische Universität München, ⁵Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, ⁶IDG Institute of Developmental Genetics, Helmholtz Zentrum München

Dynamic nuclear polarization with subsequent sample dissolution has enabled real-time studies of metabolism in biological systems. Hyperpolarized [1-¹³C]pyruvate was used to study lactate dehydrogenase activity in a prostate carcinoma cell line in vitro.