Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal MicrodeviceShan-Shan Li *1, Carman K. M. Ip *1, Matthew Y. H. Tang *2, Samuel K. H. Sy 2, Susan Yung 3, Tak-Mao Chan 3, Mengsu Yang 4, Ho Cheung Shum 2, Alice S.T. Wong 1
1School of Biological Sciences, University of Hong Kong, 2Department of Mechanical Engineering, University of Hong Kong, 3Department of Medicine, University of Hong Kong, 4Department of Biomedical Sciences, Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institutes of City University of Hong Kong
To study ovarian tumor progression in a physiologically relevant model, multicellular spheroids were cultured in a microdevice under simulated fluid flow. This dynamic 3D model emulates the intraperitoneal environment with the cellular and mechanical components where ovarian cancer metastasis occurs.
